Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis. Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.

Journal of Experimental Medicine@jem.org · last yr.

Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N

Thrilled to see our recent paper on CCDC134 highlighted in @jem.org ! Grateful for the opportunity to contribute to this field and engage in meaningful discussions!

Journal of Experimental Medicine@jem.org · last yr.

Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press! www.biorxiv.org/content/10.1...

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

biorxiv.org

I’m thrilled to share our latest work from the @rebsamenlab.bsky.social, now published in @naturecomms.bsky.social! For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo. It was a great pleasure to contribute to this project!

Rebsamen Lab @UNIL@rebsamenlab.bsky.social · 2y ago

Excited to share our latest paper out today in @naturecomms.bsky.social ! Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #ImmunoSky #InterferoSky

📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! Please share #uridine #cancermetabolism #immunometabolism @unil.bsky.social 🔗(PDF): www.jourdainlab.org/wp-content/u...

I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery! rupress.org/jem/article-... More info here: bsky.app/profile/rebs...

CCDC134 controls TLR biogenesis through the ER chaperone Gp96

A loss-of-function genetic screen identifies the ER-resident protein CCDC134 as an essential regulator of Toll-like receptor (TLR) responses. CCDC134 binds

rupress.org

Rebsamen Lab @UNIL@rebsamenlab.bsky.social · 2y ago

Very happy to share our latest work just published in @jexpmed.bsky.social! #Firstpost rupress.org/jem/article/... Our amazing PhD student @lbernaleau.bsky.social shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96. #ImmunoSky #innateimmunity #inflammation Quick summary here: