☕🍰Interested in reading more about the study? Here is the N&Vs article written by Roberto Mayor. 👉https://rdcu.be/eJqR1 bit.ly/3IEA38F

Forcing cell fate - Nature Cell Biology

The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces, long considered background players in guiding this transition, are essential regulators of chromatin accessibility and cell fate decisions.

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🎃Our October issue's out! Cover: mechanoresponsive #microtubules 👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology 🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more! www.nature.com/ncb/volumes/...

Thanks Craig Blackstone for the news & views @natcellbio.nature.com about our article thats shows how ER shape and mechanics determine the mode of cell migration. Collaboration with Simran, Pradeep and @tamaldastifrh.bsky.social. rdcu.be/eJZWf

ER shaping closes the gap in wound healing

Nature Cell Biology - During wound healing, epithelial gaps trigger curvature-dependent ER remodelling. Tubules form at convex cell edges and promote lamellipodial crawling, whereas ER sheets at...

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Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.

Nature Cell Biology@natcellbio.nature.com · last yr.

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S

We study what organelles do - beyond their "textbook" functions - during development and wound healing. Here is a story on how ER morphology shapes cells' response to wound curvature 👇

Nature Cell Biology@natcellbio.nature.com · last yr.

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S