Thanks Craig Blackstone for the news & views @natcellbio.nature.com about our article thats shows how ER shape and mechanics determine the mode of cell migration. Collaboration with Simran, Pradeep and @tamaldastifrh.bsky.social. rdcu.be/eJZWf

ER shaping closes the gap in wound healing

Nature Cell Biology - During wound healing, epithelial gaps trigger curvature-dependent ER remodelling. Tubules form at convex cell edges and promote lamellipodial crawling, whereas ER sheets at...

rdcu.be

🌊 Signals intertwine, 🔬 cells tell hidden stories, 🤖✨ SciML maps their future. Come do a PhD with us www.crick.ac.uk/careers-stud...

Congrats Margherita on completing her @physicell.bsky.social model investigating the effect of ECM organisation and remodelling and the interplay with chemotaxis on invasion www.biorxiv.org/content/10.1... Great collaboration with @jmetzcar.bsky.social , @mathcancer.bsky.social and Pradeep

The role of contact guidance and ECM remodelling in cancer invasion: a computational study

The extracellular matrix (ECM) is a complex network of fibrous proteins and other macro-molecules that provides crucial mechanical and biochemical cues that regulate cancer cell invasion and tumour pr...

biorxiv.org

RESEARCH | ‪@mic-certo.bsky.social‬ C Mauro et al. (U Birmingham) Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease. https://bit.ly/46vEjjO ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution - Nature Metabolism

Certo, Pontarini et al. provide insight into the metabolic requirements of ectopic lymphoid structure (ELS) assembly in the context of autoimmunity, and show that blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjögren’s disease.

bit.ly

Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.

Nature Cell Biology@natcellbio.nature.com · 12mo ago

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S

How does the heart age? One challenge to answering this is the lack of available human samples, and another is to integrate different molecular changes. Our paper The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression onlinelibrary.wiley.com/doi/10.1111/... 1/

The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

A multi-omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machine...

onlinelibrary.wiley.com

💫NEW: Das, @fabianspill.bsky.social & co combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization directs distinct modes of epithelial cell migration. bit.ly/3HFAQ8S

Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode - Nature Cell Biology

Rawal et al. combine intracellular cartography and biophysical modelling to reveal how edge curvature governs endoplasmic reticulum (ER) morphology, showing that curvature-dependent ER reorganization ...

bit.ly

Excited to launch the 1st UK Maths Bio Conference with a freat talk by @tiinaroose.bsky.social on image based modelling of soil

Lactate was known as a metabolic waste product from glycolysis, but more and more evidence shows it acts as a signaling molecule. Happy to have contributed with former great student @seb-math-bio.bsky.social‬ to the data analysis of a study in /@natmetabolism.nature.com showing how 1/

Congrats Kylie for publishing her first article from her PhD 'Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds' in ‪@biophysj.bsky.social‬ www.cell.com/biophysj/abs...

Measuring the Similarity of Single Molecular Localisation Microscopy Derived Marked Point-Clouds

Cellular membranes are dynamic, heterogeneous structures where lipid nanodomains (e.g., lipid rafts) play key roles in signalling, membrane trafficking, and protein function. Single-Molecule Localisat...

cell.com

Congrats Margherita for her new paper, where she investigated how cancer spheroids grow in collagen matrices with varying stiffness, implementing varying ECM properties in @physicell.bsky.social Thanks Tom Susan John and Pradeep for the collaboration www.frontiersin.org/journals/bio...

Frontiers | A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening

frontiersin.org

We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter. 🔗 www.nature.com/articles/s41... #biophysics #syntheticcell #softmatter

Meeting at the mathematical modelling/biology interface, in Birmingham in July, organised by @rosemaryjdyson.bsky.social & colleagues. sites.google.com/view/continu... 🧪🌱🌿

Continuum Mechanics in Biology 2025

A three-day workshop addressing the growing interface between continuum mechanics and the life sciences

sites.google.com

Excited to announce that registration for UK Maths Bio 2025 is open. We have an exciting list of confirmed speakers and are looking for more exciting talks and posters from the community. Please submit your abstract by 31 March 25. ukmathbioconference.github.io

Our new review discusses how mathematical models can help understand the similarities and differences between endothelial and epithelial cells. Thanks Pradeep, Raul, Maria Jose and Effie for the collaboration www.cell.com/trends/cell-...

Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology

Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Compu...

cell.com

And congrats @Blaine_VR again, I can't recall I ever had two papers on ArXiv on the same day :) This model is about IBD and identified how mutants and inflammation affect the spread

Congrats Blaine for completing the paper 'Eco-evolutionary dynamics of a trait-structured predator-prey model' which features an analytic analysis of a model with population heterogeneity, transient, and long-term dynamics arxiv.org/abs/2501.07379

Eco-evolutionary dynamics of a trait-structured predator-prey model

The coupling between evolutionary and ecological changes (eco-evolutionary dynamics) has been shown to be relevant among diverse species, and is also of interest outside of ecology, i.e. in cancer evo...

arxiv.org

Excited to announce the first UK Maths Bio Conference 4-5 September in Birmingham ukmathbioconference.github.io . Registration will open in a few weeks, save the date! Thanks to my amazing co-organisers Valeria, Kyle, Rachel and Phil for all their work planning the conference.

Congrats Zipeng on completing his paper iTARGET:Interpretable Tailored Age Regression for Grouped Epigenetic Traits arxiv.org/abs/2501.02401

iTARGET: Interpretable Tailored Age Regression for Grouped Epigenetic Traits

Accurately predicting chronological age from DNA methylation patterns is crucial for advancing biological age estimation. However, this task is made challenging by Epigenetic Correlation Drift (ECD) a...

arxiv.org

Congrats Rico on publishing his article 'Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa'. This paper was motivated to increase global representation in biomedical research. Our collaborators at BMS were specifically interested in t.co/Tj6ShrUoVA 1/

Still time to apply for positions in Maths @unibirmingham. We hire on every level, from PhD students to prestigious 125 Anniversary Chair positions, deadline early January. Please spread the word! www.systems-mechanobiology.com/jobs

Systems-Mechanobiology - Jobs

systems-mechanobiology.com

I am looking for a postdoc to join our interdisciplinary team developing mechanistic or machine learning systems models of ageing and age-related diseases. One focus is on identifying geometrical and mechanical alterations such as cell and organelle shape changes 1/

I am looking for PhD students who love to develop models and ML methods to understand how mechanical, geometrical or metabolic features of cells and tissue change in aging, and how this affects the emergence of age-related diseases. www.findaphd.com/phds/project... www.findaphd.com/phds/project...

Modelling Metabolic Drivers of Ageing and Diseases at University of Birmingham on FindAPhD.com

PhD Project - Modelling Metabolic Drivers of Ageing and Diseases at University of Birmingham, listed on FindAPhD.com

findaphd.com

We are looking for a PhD student who is excited about mitochondria and their role in diabetes t.co/Y0fPG459Ad

We have multiple positions as Assistant and Associate Professor at the University of Birmingham in any area of Mathematics available. Come join our collaborative environment and please spread the word. www.jobs.ac.uk/job/DKT142/a...

Assistant Professor (Research and Education) at University of Birmingham

Explore an exciting academic career as a Assistant Professor (Research and Education). Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk