Bravo and thank you to Riley, Mavrick and Conard for the generous gift! 🙏 You're in great hands with the @horanilab.bsky.social !!
WashU Ciliopathy Research Group
@wu-ciliopathygroup.bsky.social
A multidisciplinary team of investigators at Washington University in St Louis that perform fundamental, translational, and clinical research on human ciliopathies.
Major congratulations to Steve Brody (@brodylab.bsky.social) for his election to the Association of American Physicians (AAP). A well deserved honor for an incredible physician-scientist 👏👏 Yet another 🏅 for #cilia and #ciliopathy research!
🚨 Deadline Extended! 🚨 The Cilia 2027 Best Image Competition is now open until May 7, 2026. Got a striking microscopy image? This is your chance to have it showcased at #Cilia2027 🦠🏆 Submit now and share your science through art! #MicroscopyContest #ScienceArt #CellBiology #BioImaging
Congratulations to our very own Susan Dutcher @dutcherlab.bsky.social for being elected to the National Academy of Sciences! A truly remarkable achievement for an amazing scientist. And a huge 🏆 for #cilia research! @nasonline.org @washugenetics.bsky.social @washu.edu
National Academy of Sciences@nasonline.org · 4mo agoWe are thrilled to announce the election of 120 members and 25 international members to the National Academy of Sciences in recognition of their distinguished and continued achievements in original research. Congratulations to our new #NASmembers and welcome to the Academy! 🎊
One week to go! ⏳ Don’t wait until the final hour—get those entries in now! Check the original post below for all the details. 👇 #Cilia #Cilia2027 #SciArt #Microscopy
EuroCilia2027@eurocilia.bsky.social · 5mo ago📣 The Cilia2027 Best Image Competition is open! 🧬✨ 🏆 1st Prize: Cover of the program & website + FREE registration to Cilia2027 🥈🥉 2nd & 3rd: Featured in the event screensaver + website Submit your best cilia visuals: forms.gle/jUC2tnsa5Cs8... #Cilia2027 #Microscopy #SciArt #Cilia
Bénédicte Durand discusses Shan Wang, Xin Liang et al.’s new study in @jcb.org (doi.org/10.1083/jcb....) which describes how the motor protein Kif19A shapes the tips of fly mechanosensory #cilia. rupress.org/jcb/article-...
CenSpark story is now published in @natchembio.nature.com. We engineered a dual-ligand fluorescent probe to selectively "light up" centrioles & cilia. Massive thank to Pierre Gönczy, @lreymond.bsky.social and @ghatzopoulos.bsky.social for the guidance. Check it out 👉: doi.org/10.1038/s415...
Development of the fluorescent probe CenSpark for labeling centrioles and cilia - Nature Chemical Biology
CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of cen...
doi.org
Our preprint about Togaram1 mouse knockout brain phenotypes is on bioRxiv! This is a model of Joubert Syndrome ciliopathy caused by loss of Togaram1 (aka Crescerin1 aka FAM179B). Primary #cilia defects in neural stem cells. Neurogenesis, mitotis, apoptosis, morphogenesis phenotypes! #cellbio
bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 4mo agoMicrotubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia https://www.biorxiv.org/content/10.64898/2026.04.13.717734v1
Stentors are fascinating trumpet-shaped protozoa that can be seen with the naked eye. Their synchronized cilia create water currents to capture food effortlessly.
Calling all #cilia researchers. Our new Community Page presents CiliaKB, a manually curated #KnowledgeBase that serves as a one-stop platform for researchers to rapidly access mechanistic #data and mine for translational clues about cilia. 🧪 #CellBiology
CiliaKB: A comprehensive knowledge base for cilia-associated genes
Cilia dysfunction is implicated in a range of disorders. This Community Page presents CiliaKB, a manually curated knowledge base that serves as a one-stop platform for researchers to rapidly access…
plos.io
The House voted yesterday on the conferenced appropriations bill (H.R. 7148), passing it by a vote of 341 in favor and 88 against. This 954-page bill includes funding for NIH, CDC, and other federal science agencies. The NIH’s overall budget increased by 0.6% compared to FY25.
Unfortunately, the CDC budget was reduced by 15.8%. Write your senator as they vote next week on the bill
Listen to me folks. We all agree that this SCIENCV thing sucks. Extra work for no reason. So let's all agree not to nitpick about things on the Biosketch when it's our turn to review grants. Be a good reviewer and let's not screw ourselves. Yes, I'm talking to YOU!
Mark your calendar for the best #cilia conference out there! 👇 Our very own Susan @dutcherlab.bsky.social is presenting one of the keynotes!! 🙌
EuroCilia2027@eurocilia.bsky.social · 7mo ago𝗠𝗲𝗲𝘁 𝗼𝘂𝗿 𝗸𝗲𝘆𝗻𝗼𝘁𝗲 𝘀𝗽𝗲𝗮𝗸𝗲𝗿𝘀 𝗳𝗼𝗿 #𝗖𝗶𝗹𝗶𝗮𝟮𝟬𝟮𝟳! We are grateful for their participation and look forward to welcoming the cilia community on 8-12, March 2027. Wishing you all a happy and inspiring 2026! 🎉 #Cilia #Milan
Happy #FluorescenceFriday 🔬 all! Is that the Eye of Sauron? No, it's a developing mouse oocyte (beautiful cells to image btw). But what are those filaments inside the cell? Stay tuned 😉
Bummed to miss #ASCB this year (one of my fav meetings), but the lab is well represented! Stop by poster B169 today and Maneesha will tell you all about her work on basal bodies and cilia homeostasis in multiciliated cells 👇 #CellBio2025
Another great review for lovers of #centrioles and #centrosomes, this one from our group members @ericabiven.bsky.social and @jenntrosome.bsky.social 👇😍 www.sciencedirect.com/science/arti...
I am excited to share our latest preprint describing comparative transciptomic analysis between primary ciliary dyskinesia and cystic fibrosis. The more we understand the pathways driving disease the better equipped we are to find a cure. www.biorxiv.org/content/10.1...
biorxiv.org
WashU is in the house! Susan and Moe in action at the CSH Asia conference on #cilia and #centrosomes in Suzhou, China.
Big news from our group! 👏👏
WashU Nephrology@washunephrology.bsky.social · 9mo agoProud moment for #WashU Nephrology, Pulmonary, and Genetics! Drs. Moe Mahjoub (@mahjoublab.bsky.social), Susan Dutcher (@dutcherlab.bsky.social) & Steven Brody (@brodylab.bsky.social) are advancing lung disease research with two #NIH R01 awards! #WashUMedicine nephrology.wustl.edu/moe-mahjoub-...
Checkout the new preprint from @horanilab.bsky.social 👇
HoraniLab@horanilab.bsky.social · 10mo agoI am excited to share our preprint on the use of machine learning to identify abnormal cilia function. I am proud of Nicholas Hadas, a talented PhD candidate, for his hard work in compiling the code and preparing this manuscript. www.biorxiv.org/content/10.1...
#Actin and #cilia fans, we have a #FREE ACCESS #Review #article available for you in #CYTOSKELETON! The Role of #Microfilaments in Cilia Formation and Function. Read it here for FREE: onlinelibrary.wiley.com/doi/full/10....
Despite the mess, we are grateful to be funded, have exciting science happening, and have an opening for a postdoc! If you are interested in sensory biology and esp in cilia, thermosensation, or interoception, and would like to join an interactive & supportive group - please email. Please RT 🙏
Polychaete larva cilia currents in timelapse. #sciart #microscopy #plankton
New research has unravelled the mystery of how microscopic cilia choreograph their “Mexican wave”, enabling marine creatures to swim. Cilia are tiny, hair-like protrusions found in many organisms. Yet despite decades of research, the mechanisms of cilia coordination remained disputed.
Our collaboration with @mbonhivers.bsky.social is now out in @plosbiology.org! 🎉Using U-ExM, we mapped the formation of the flagellar pocket collar in T. brucei. Huge thanks to everyone involved — one step closer to #PhDone! #ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky
PLOS Biology@plosbiology.org · 10mo agoThe flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
I am excited to share the new PCD diagnostic guidelines. A great collaboration with PCD experts from all over the world. publications.ersnet.org/content/erj/...
European Respiratory Society and American Thoracic Society guidelines for the diagnosis of Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is caused by pathogenetic variants in >55 genes. PCD is associated with early-onset chronic wet cough and rhinosinusitis, laterality defects, middle ear disease, and reduced fertility. The clinical presentation is heterogeneous, and diagnosis often relies on multiple tests. The American Thoracic Society (ATS) and European Respiratory Society (ERS) have previously developed separate guidelines for diagnosis. Here, ERS and ATS members systematically reviewed the literature on diagnostic tools used in practice and developed unified evidence-based guidelines for PCD diagnosis using GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology, and a transparent process of decision-making using Evidence-to-Decision (EtD) frameworks. The Task Force panel formulated three PICO (Patients, Intervention, Comparison, Outcomes) questions and three narrative questions. The accuracies of high-speed video microscopy (HSVM), immunofluorescence (IF), and nasal nitric oxide (nNO) were compared to a reference test of transmission electron microscopy (TEM) and/or genetics. The panel gives strong recommendation for use of HSVM, IF, and nNO as adjunct tests to TEM and/or genetics for PCD diagnosis. However, no adjunct test is suitable as a standalone test to diagnose PCD and no single adjunct or reference test is suitable to exclude PCD. Pursuing a genetic diagnosis is encouraged due to the implication on management. The panel emphasizes that tests should meet a minimum standard and proposes evaluation of patients at a referral centre experienced in diagnosis. The pretest probability based on symptoms should be considered when interpreting results.
publications.ersnet.org