Fantastic collaboration with wonderful colleagues resulted in this work: three structures, new channel activators, new binding site is revealed, new mode of regulation- all in one paper! @qingweiniu.bsky.social @ruizhangmt.bsky.social izhangmt.bsky.social + dream team www.nature.com/articles/s41...

Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1 - Nature Communications

Kir7.1 is an essential potassium channel. The authors report cryo-EM structures in multiple states revealing how bioactive lipids modulate Kir7.1, and define a pharmacological landscape that identifie...

nature.com

Glad to contribute to this wonderful project!

Tzviya Zeev-Ben-Mordehai@tzviyazbm.bsky.social · 2mo ago

Fantastic work of @jojudernatz.bsky.social Revealing a novel seam binding complex in spermatid microtubules

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

I am so grateful to the Blavatnik Family Foundation and the New York Academy of Sciences for this honor. Can’t wait to be back to the lab and celebrate with lab members on this special recognition of their hard work.

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 5mo ago

Congratulations to @kellythd-nguyen.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has been named the Life Sciences Laureate at the 2026 Blavatnik Awards in the UK 🎉 Read the full news story here: mrclmb.ac.uk/news-events/... #LMBNews #Blavatnik2026

At long last, the Chlamy chloroplast ribosome hat 🎩 (now renamed the arm 💪) is here to say hello👋! We first spotted this extended structure in green algae a decade ago, and @florentwaltz.bsky.social did beautiful work bringing it into focus! #CryoEM ❄️ #TeamTomo 🔬 #PlantScience 🌾 #ProtistsOnSky 🧪

Florent Waltz@florentwaltz.bsky.social · 6mo ago

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action! www.biorxiv.org/content/10.6...

Helen Foster@helenfoster.bsky.social · 6mo ago

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social www.biorxiv.org/content/10.1...

Happy Halloween everyone! 🎃

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

New lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz

Excited to share our preprint on cytoskeletal organization in astrocytes! biorxiv.org/content/10.110… Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes. Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓 1/x

HHMI adopts Plan U journals.plos.org/plosbiology/...

Yifan Cheng to Receive 2026 Anatrace Membrane Protein Award buff.ly/ooI1UDy

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 11mo ago

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

Sequence-based prediction of intermolecular interactions driven by disordered regions

Intrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...

science.org

Alex Holehouse@alexholehouse.bsky.social · 2y ago

Excited to share new work from Garrett Ginell et al where we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions www.biorxiv.org/content/10.1...

The fantastically successful NIGMS MIRA R35 "expired" on May 17, after the most recent deadline--these removals are the most aggressive attack on American science in the current series of devastating actions 🧪

Gabi Serrato Marks@gserratomarks.bsky.social · last yr.

NIH moved up the expiration date for some funding opportunities, effectively *canceling* the next application date without removing it from the standard table. I can't even imagine how many people are still prepping these grants. 👀 List of impacted opportunities: grants.nih.gov/grants/guide...

"to run a contest that you end up not funding as a private organization at this time is… both extremely wasteful of these people’s time, and just devastating in terms of morale." I spoke with @aniloza.bsky.social at STAT today about HHMI's decision not to fund this round of Hanna Gray applicants.

Private funder HHMI pauses postdoc fellowship

As HHMI pauses Hanna Gray fellowship applications, opportunities for young scientists shrink further, making them look overseas.

statnews.com

Alex Long, the last postdoc from my lab at Stanford, is starting her own lab, continuing her beautiful work on evolutionary cell biology using chytrid fungi as a model. Check it out! alonglab.org

Long Research Group

Long Research Group - Univ. Kentucky

alonglab.org

Conference alert: Machines acting on DNA and RNA Madrid, May 28-30 Abstract deadline: April 24 Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below. Please repost.

Introducing blebbisomes! Cover art by @ento-sanchez.bsky.social! #CellBiology Article: www.nature.com/articles/s41...

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention. www.science.org/doi/10.1126/...

Another wonderful collaboration with @alanbrownhms.bsky.social lab 👇 Zhang lab (co-first author @qingweiniu.bsky.social) contribute the doublet structure from Crithidia fasciculata, a model organism that infects mosquitoes.

Matt Doran@matthdoran.bsky.social · last yr.

I am super excited to share our latest work on the structures of doublet microtubules from trypanosomatid parasites, the causative agents of leishmaniasis, Chagas disease, and African sleeping sickness. tinyurl.com/48sh3xn5

😳😱 R.I.P. Karen

Alexey Amunts@amunts.bsky.social · last yr.

Sad news about Karen Davies' passing. Karen was an inspiration in bioenergetics and cryoET. Her pioneering postdoctoral work on ATP synthase and respiratory supercomplexes marked turning points in the field. I created Scholar profile to acknowledge her contribution scholar.google.com/citations?hl...

Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.

Thrilled- the @bsdb.bsky.social medal in Wolpert's name marks 'vastly important contributions to research in our field, but also to the communication of its problems to a broader audience'. Communicating the importance of our research has never been more important when science is under such threat!

British Society for Developmental Biology@bsdb.bsky.social · last yr.

We are delighted to announce that the winner of the 2025 Wolpert medal is Pleasantine Mill! bsdb.org/2025/03/05/2...

The @jcellsci.bsky.social has an upcoming special issue - Cilia and Flagella: from Basic Biology to Disease – guest edited by Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen) . The submission deadline is 31 March. journals.biologists.com/jcs/pages/ci...

Some good news: The Federal Register has just posted NIH study sections, which are to meet in late March. NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...

NIH announces some key grant-review meetings will restart in late March

Trump policy blocking required notices has frozen reviews of thousands of grants

science.org