Patrick Pausch
@patrick-pausch.bsky.social
Research Professor & Group Leader at Vilnius University, LSC-EMBL - CRISPR, Gene Editing and Microbiology
Happy to share the first preprint out of the Nomburg lab! Many aspects of cellular immunity are shared across the tree of life. Here, we show that some of these conserved aspects of cellular immunity are mirrored by conserved effectors of immune antagonism. Thread below! 1/15
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2w agoConserved folds enable immune antagonism across the tree of life https://www.biorxiv.org/content/10.64898/2026.07.21.739742v1
1/4 Every good defence needs a backup! 🛡️⚔ Out now in @natrevmicro.nature.com our Comment on "𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝗮𝗳𝗲𝗴𝘂𝗮𝗿𝗱𝗶𝗻𝗴"! 🎉 🔗 www.nature.com/articles/s41...
Immune safeguarding as a conserved principle of antiviral defence - Nature Reviews Microbiology
All organisms defend against viral infections through active immunity mechanisms that clear the virus or population-level mechanisms that cause regulated cell death. Recent research increasingly shows...
nature.com
1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 biorxiv.org/content/10.6...
🧬 Thrilled to share our latest @biorxiv-microbiol.bsky.social preprint! Here we find that Retron-IX build crazy supramolecular rings scaffolded by DNA molecules that sense phage infection! www.biorxiv.org/content/10.6... Read more below🧵! (1/X)
Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!
Structure and evolution-guided design of minimal RNA-guided nucleases
The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...
science.org
PhD opening in my lab @jagiellonskiuni.bsky.social: using AI to predict how phage enzymes break down bacterial capsules — joint work with ML group GMUM and Zuzanna Drulis-Kawa's phage lab (Wrocław), spanning genomics, AI & evolution. mostowylab.com/job-phd-ai-d... Deadline: 15 August 2026
A DNA-scaffolded Retron Ring Mediates Antiphage Immunity https://www.biorxiv.org/content/10.64898/2026.07.14.737667v1
Join us at the EMBO Young Scientists’ Forum 2026 in Dubrovnik, 28–30 October. All areas of life sciences are welcome! ⏰ Early-bird registration ends 15 July. #EYSF2026 #LifeSciences
Klebsiella phages often modify the bacterial capsule instead of degrading it, stripping acetyl groups. Nobody's traced how this evolves. I'm hiring a computational postdoc to find out — Kraków, apply by 21 July. mostowylab.com/job-postdoc-...
We often talk about complex protein folds but what does that really mean? Turns out we don't have a good metric for it. So we made a game to make one! Head over to our website to vote on which fold you think is more complex and why! pacesalab.com/foldcomplexi...
Do you need a super active #CRISPR Cas for in vivo editing? I have not one, but two options for you. Activities rival SpyCas9, but they fit into an scAAV. Check out our latest paper, co-led by Fedor Gorbenko and Irene Sala. Just out in Genome Research. link.springer.com/article/10.1...
This year #EYSF2026 is in Dubrovnik, Croatia! 🔗 event.fourwaves.com/eysf/pages ▶️ For early-career life scientists across Europe: interdisciplinary presentations, networking, collaborations, and creative scientific exchange. & we have a special session #ProtistsOnSky
1/4 Excited to share our new preprint on phage genome editing: Targeted DNA nicking enables efficient, single-step and counterselection-free editing of bacteriophage genomes Preprint: lnkd.in/dv4g5kW6
This link will take you to a page that’s not on LinkedIn
lnkd.in
Our lab website is finally online! pacesalab.com You can find information about our research, publications, and on-going developments in the lab.
Und das ganze Auditorium schweigt...wir müssen nochmal über Zivilcourage reden.
Professorin berichtet über Morddrohungen an Uni: "Marburg ist für mich zum Angstort geworden"
Schmierereien mit Mordaufrufen, Störungen in Seminaren und wachsender Druck: Die Marburger Historikerin Christina Brüning spricht erstmals öffentlich über Bedrohungen gegen sie, warum sie sich an ihre...
hessenschau.de
Phage receptor-binding proteins are known for their LEGO-like modularity, but we still do not fully understand their evolutionary potential and how it shapes phage host range. Our new preprint examines this systematically in Klebsiella phages. 🔗 www.biorxiv.org/content/10.6... Thread 🧵
Thrilled to share a major milestone from our long-running collaboration with Zuzanna Drulis-Kawa's lab in Wrocław — DepoCatalog, is now out in @natcomms.nature.com: 129 Klebsiella phage depolymerases, 75 capsule types, 5-class structural framework and public database. www.nature.com/articles/s41...
📢 Registration for our International Symposium on “New Concepts in Prokaryotic Virus-Host Interactions” is now open! 🗓️ 5–7 October 2026 📍 Harnack House, Berlin, Germany ➡️ Information and registration: spp2330.de/symposium-20...
Polish phage science meets Polish visual storytelling 🇵🇱🦠 To celebrate our last paper, we collaborated with an artist who previously worked on The Witcher 3 — to create a comic about phages and why understanding them matters in the fight against antibiotic-resistant bacteria. Comic below 👇
Rafal Mostowy@rafalmostowy.bsky.social · 3mo ago🎉 New in @plosbiology.org: Temperate phages of Klebsiella pneumoniae show capsule-driven host tropism — but how? The working assumption was depolymerases: enzymes that chew through the bacterial sugar capsule. Turns out that's not the whole story. 🧵 journals.plos.org/plosbiology/...
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity. Aaron Whiteley
Addgene: Phage ORFeome Library
Use the Phage ORFeome Library to uncover the triggers responsible for immune activation.
twp.ai
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze! www.science.org/doi/10.1126/...
Science | AAAS
science.org
PhD student or postdoc in microbiology? 🔬🦠 We are opening a new round of our career orientation program VAAMentoring – Get matched with an experienced scientist 👨🔬👩🔬 to help you find your direction🎯 Apply by May 15, 2026 More info🔗 t1p.de/2iamo #microbiology #mentoring #VAAM #PhDlife #Postdoc
PostDoc position available! (links in post below) Feel free to share!
‼️Please share‼️ Nemudryi lab is looking for postdocs to join our team and study: 🦠 Bacterial phage defense mechanisms 🧬 RNA repair & CRISPR-based RNA editing Excited about RNA, host-virus interactions & mechanistic biology? Let's talk! Apply: explore.jobs.ufl.edu/en-us/job/53...
University of Florida - Details - Postdoctoral Associate
explore.jobs.ufl.edu
How diverse is bacterial immunity ? We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems. 👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie... Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
science.org
A big advance in the field of bacterial immunity, from the Bernheim and Laub labs
Nature@nature.com · 4mo agoBacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies. go.nature.com/4dqQnXI
📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Only 9 days left to apply for this post doctoral position. Please share and forward to your colleagues.
Peter Fineran@peterfineran.bsky.social · 5mo agoNew post-doctoral research position in my phage-host interactions (Phi) laboratory in @otagomicroimmuno.bsky.social at @universityofotago.bsky.social New Zealand. The project is focused on defences against jumbo phages. Please share and if interested apply using the link in the comments.
