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Green Lab JHMI

@greenlab.bsky.social

Ribosome is life. Posts by grads/postdocs, approved (sometimes) by Rachel Green. @Johns Hopkins Medical Institute https://greenlabjhmi.org

5 Posts146 Follower6 Folgt
Green Lab JHMI@greenlab.bsky.social · 2d ago

U should check DIS out! In our new paper (and sequel to our RIOK3 story), we find that rRNA oligo(U) tailing and DIS3L2-mediated decay drive 40S ribosome degradation 💫 www.cell.com/molecular-ce...

Oligo(uridine) tailing and exonucleolytic decay drive 40S ribosome degradation in response to stress

40S ribosomes are degraded in diverse stress conditions. Diehl et al. find that in response to stress, TUT7 is recruited to ubiquitylated 40S ribosomes and adds 3′ oligo(U) tails to the 18S rRNA. Iter...

cell.com

Green Lab JHMI@greenlab.bsky.social · last mo.

Pre-print alert! SERBP1 regulates the interactions between ribosomes and different proteins. We find that it prevents interactions between ribosomes and RNF10/RIOK3 to protect ribosomes from selective 40S degradation. Congrats! @nicollearosa.bsky.social www.biorxiv.org/content/10.6...

SERBP1 is a master regulator of ribosome interactions

Ribosome function depends on interactions with diverse proteins whose activities determine translational efficiency, impose quality control and activate signaling pathways. These many competing activi...

biorxiv.org

Green Lab JHMI@greenlab.bsky.social · 3mo ago

Wait, what?! This isn’t about ribosomes? Check out our new work where we find that a #Legionella effector thought to target host translation instead targets metabolism by modifying a host glycolytic metabolite. Led by @drjoshblack.bsky.social www.cell.com/molecular-ce...

The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate

Black et al. identify the L. pneumophila effector SidL as an adenylyltransferase that targets host glycolysis. SidL covalently modifies the glycolytic intermediate 3-phosphoglycerate (3PG) with AMP, g...

cell.com