Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice

Genetic delivery of designed protein nanoparticles displaying the SARS-CoV-2 RBD elicits potent neutralizing antibody and CD8 T cell responses.

bit.ly

First Sin Nombre virus (Orthohantavirus sinnombreense) genome sequences from the Northwestern United States

We report the first Sin Nombre virus (SNV) genome sequences from the Northwestern United States and the first SNV sequences recovered from voles. Analysis of samples collected from 189 individual rode...

biorxiv.org

Recording artist career comparison through audio content analysis | Royal Society Open Science

Audio content analysis can be deployed to examine relationships within and between collected works of different music artists, allowing a new approach to comparative analysis of recorded music within ...

royalsocietypublishing.org

Oxytocin facilitates human touch-induced play behavior in rats

Hayashi et al. demonstrate that human touch-induced pleasurable tickling promotes affinity between rats and human hands. This is accompanied by increased OTR expression in the VMHvl, and blocking the ...

cell.com

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates

Nonstabilized SARS-CoV-2 spike mRNA vaccination elicited distinct antibodies to either Omicron variants of concern or preemergent sarbecoviruses.

science.org

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses - Nature Communications

This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close rela...

shorturl.at

What’s so special about orange cats? Turns out they’re freaks of nature | CNN

Researchers identified an unusual genetic mutation in orange domestic cats that has not been found in any other animal, according to a new study.

cnn.it

Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines

Vaccines against emerging SARS-CoV-2 variants and sarbecoviruses with pandemic potential must elicit a robust humoral immune response in a population imprinted with the SARS-CoV-2 spike (S) protein. H...

biorxiv.org

Genomic evidence for behavioral adaptation of herding dogs

The whole-genome sequences of herding dogs reveal how selection has sculpted the unique behavioral traits.

scim.ag

Twin modelling reveals partly distinct genetic pathways to music enjoyment - Nature Communications

Here, Bignardi et al. report on a study of over 9,000 Swedish twins that indicates the ability to enjoy music is influenced by multiple partly distinct genetic factors.

nature.com

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity | mSphere

Emerging coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV cause a range of disease outcomes in humans from an asymptomatic, moderate, and severe respiratory disease that can progress to death but...

journals.asm.org

Ebola disease: bridging scientific discoveries and clinical application

The west Africa Ebola disease epidemic (2014–16) marked a historic change of course for patient care during emerging infectious disease outbreaks. The epidemic response was a failure in many ways—a slow, cumbersome, and disjointed effort by a global architecture that was not fit for purpose for a rapidly spreading outbreak. In the most affected countries, health-care workers and other responders felt helpless—dealing with an overwhelming number of patients but with few, if any, tools at their disposal to provide high-quality care.

thelancet.com

Animal models of Long Covid: A hit-and-run disease

Animal models will inform our understanding of Long Covid and will aid in identifying therapeutic targets.

science.org

Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice

Martinez et al. demonstrate proof of concept that a single ferritin nanoparticle vaccine displaying the receptor-binding domains of MERS-related and SARS-related zoonotic, epidemic, and pandemic coro...

cell.com

The manifold costs of being a non-native English speaker in science

This study reveals that non-native English speakers, especially early in their careers, spend more effort than native English speakers in conducting scientific activities, from reading and writing pap...

journals.plos.org