The remarkable @jeremyahollis.bsky.social defended his PhD thesis on the evolutionary innovations and landscapes of integrin proteins from Melody Campbell & Malik labs today to a packed house @fredhutch.org @basicsci.fredhutch.org Jeremy is a force of nature & one of the kindest people I’ve ever met

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

Sold out in person 🎟️ but you can still join live online 📡 Hear @veeslerlab.bsky.social & leaders in viral immunity at Viral Pathogenesis and Immunity, June 15-18. @hhmi-science.bsky.social @globalvirusnews.bsky.social @amersocvirology.bsky.social @aai.org @escvirology.bsky.social #KSViral26

Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵

Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor pubmed.ncbi.nlm.nih.gov/42054371/ #cryoEM

Can we use #proteindesign to develop countermeasures before viruses cause pandemics? We describe the computational design of an ultrapotent and broadly neutralizing deltacoronavirus miniprotein in our latest work led by Nathan Avery @hhmi-science.bsky.social 1/12 www.pnas.org/doi/10.1073/...

How are host proteases promoting coronavirus entry into cells? Find out by reading our latest manuscript led by @mattmccallum.bsky.social Brett Case Jack Brown & @youngjunpark.bsky.social in collaboration with @msdiamondlab.bsky.social 1/19 www.nature.com/articles/s41...

TMPRSS2-mediated coronavirus spike activation and inhibition - Nature Structural & Molecular Biology

Here, the authors elucidate TMPRSS2 protease recognition of the SARS-CoV-2 spike S2′ cleavage site, revealing the molecular basis of activation of membrane fusion, and show that antibodies recognizing...

nature.com

The early release version of our #cryoEM work on CDK11-cyclin L-SAP30BP has now been published at Nature Communications: www.nature.com/articles/s41... We got very helpful comments from the reviewers and added more structural analysis and biochemistry to support our conclusions. Please have a look!

Basil Greber@bjgreber.bsky.social · 4mo ago

Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation. www.biorxiv.org/content/10.6...

Really honored to be named a 2026 Ohio State Distinguished University Professor. Thank you to my mentors, trainees, and collaborators for all the support and encouragement. faculty.osu.edu/news/2026/04...

Out now at PLoS Pathogens @plos.org. Nice collaboration with @danielhurdiss.bsky.social @utrechtvirology.bsky.social. Some beautiful glycoproteomics work by @tshamorkina.bsky.social mapping N- and O-glycan shield of coronaviruses infecting whales and dolphins 🐋🐬🐳. journals.plos.org/plospathogen...

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans @cp-cellreports.bsky.social www.cell.com/cell-reports... @veeslerlab.bsky.social

🚨 new paper alert 🚨 Here we demonstrate increased anti-RBS neutralizing responses elicited by stabilized influenza H5 immunogens: bit.ly/4u8UxJl

Big thanks to Aakanksha @singhvilabglia.bsky.social for the nomination, to J. Bai and @nlehrbach.bsky.social for supporting it, to A. Calixto, S. Karimzadegan, P. Gurung, J. Cattin-Ortola, M. Crawford, for their supportive letters and to all my mentees for making this job colorful and meaningful ♥️

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · 5mo ago

Congratulations to @irinakitop.bsky.social on winning the 2026 @genetics-gsa.bsky.social Mentorship Award. She was selected in recognition of her exceptional mentorship of more than 30 trainees and her published work on mentorship, STEM education, and career choice. buff.ly/6zAwQQ1

In new study led by Brendan Larsen, we map functional constraint across the Nipah virus F protein to define constrained epitopes for antibody targeting and identify mutations that stabilize the prefusion conformation for vaccine immunogens. www.pnas.org/doi/10.1073/...

Functional and antigenic constraints on the Nipah virus fusion protein | PNAS

Nipah virus is a highly pathogenic virus in the family Paramyxoviridae that utilizes two distinct surface glycoproteins to infect cells. The recept...

pnas.org

In new study we examine constraints on evolution of endemic "common-cold" coronavirus 229E We find strong tradeoff between antibody neutralization & receptor binding, due to up-down position of spike RBD www.biorxiv.org/content/10.6... See lead author Sheri Harari's summary: x.com/SheriHarari/...

Our latest paper shows that IFITM3 deficiency allows SARS-CoV-2 to adapt more easily to a new host species. Mouse-adapted beta and omicron variants from this work maintained their unique tropisms and pathogenic characteristics allowing exciting comparative studies. www.nature.com/articles/s41...

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/

Fran Bottanelli@franbottanelli.bsky.social · 6mo ago

Exciting preprint from the @merz.bsky.social lab proposing how fidelity of membrane fusion is achieved #membranes #trafficking

We studied how the glycan shield of alphaherpesvirus fusion protein gB mediates host co-receptor interactions. Great work by Sabrina, check it out! www.biorxiv.org/content/10.6...

Our paper on the role of #SARSCoV2 NSP3 in stress granule control is now out in JVI. Reposting our original BioRXIV thread on the summary. journals.asm.org/doi/10.1128/...

Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity | Journal of Virology

Stress granules play a key role in host-antiviral defenses, and viruses have developed strategies to antagonize their activity. For SARS-CoV-2, the virus has two proteins that antagonize stress granul...

journals.asm.org

The Menachery Lab@themenacherylab.bsky.social · 8mo ago

A new preprint from our group on control of stress granules (SGs) by #SARSCoV2. Working with Jakob Nilsson's group, we identified key residues in SARS2 NSP3 critical for binding FMRP proteins & disrupting SGs formation. www.biorxiv.org/content/10.1...

Potent neutralization of Marburg virus by a vaccine-elicited antibody www.nature.com/articles/s41...

Potent neutralization of Marburg virus by a vaccine-elicited antibody @nature.com @hhmi.org @veeslerlab.bsky.social @virbiotechnology.bsky.social www.nature.com/articles/s41...

Delighted to share the peer-reviewed version of our article describing a prefusion-stabilized MARV GP vaccine immunogen and a best-in-class MARV neutralizing and protective antibody! Led by @aminaddetia.bsky.social with @virbiotechnology.bsky.social @hhmi.org www.nature.com/articles/s41...

Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

Our latest work on #COVID immunity and imprinting in humans. Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others! www.biorxiv.org/content/10.1...

Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans

The first exposure to a pathogen or an antigen profoundly impacts immune responses upon subsequent encounter with related pathogens. This immune imprinting explains that infection or vaccination with ...

biorxiv.org

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase

Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

science.org

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome. We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org. pubs.acs.org/doi/10.1021/... @xdh.bsky.social @hangryhobbit.bsky.social