Marit Petzka

@maritpetzka.bsky.social

cognitive neuroscience: memory. learning. sleep. replay. postdoc: SchuckLab | Uni Hamburg

Can we study MTL ripples non-invasively? New preprint! We show that source-resolved MEG tracks ripple-like activity during sleep that: • localizes to the MTL • follows the canonical SO–spindle hierarchy • matches an iEEG benchmark • indexes memory reactivation www.biorxiv.org/content/10.6...

Non-invasive tracking of ripple-like activity during human sleep using MEG

Hippocampal ripples are considered a key mechanism of sleep-dependent memory consolidation. In humans, however, their direct investigation has relied on invasive recordings from patients with epilepsy...

biorxiv.org

Excited to share my first #preprint with @matthiasnau.bsky.social on how gaze behavior shapes brain activity during eyes-closed rest and sleep! Gaze-dependent activity was widespread even during sleep, including in many visual cortices, and altered brain-wide functional connectivity! 🧵 1/8

Brain-wide gaze-dependent activity during eyes-closed rest and sleep

Gaze behavior and brain activity are tightly coupled during perception and mental imagery. Whether this coupling extends to eyes-closed states remains largely unknown, primarily because measuring eye ...

biorxiv.org

New preprint! We show low arousal states promote hippocampal ripple genesis in sleep and wake. This bridges rodent work, where ripples predominate during sleep, with human studies reporting ripples during active behavior, identifying low arousal as a common mechanism www.biorxiv.org/content/10.6...

Arousal state modulates human hippocampal ripples

Hippocampal ripples are transient, high-frequency oscillations linked to memory replay and consolidation. Ripples are well-characterized in rodents to occur during periods of behavioral inactivity (i....

biorxiv.org

🧠 New preprint! How well can current algorithms *actually* detect neural "replay" in the human brain under absolutely optimal conditions? We built FASTIMAGES: A combined MEG + fMRI benchmark with KNOWN neural sequences, so replay-detection methods can finally be validated against a ground truth.

FASTIMAGES: Validating replay detection methods in human neuroimaging

A combined MEG + fMRI benchmark dataset with known neural sequences to validate replay detection methods (TDLM and SODA).

cimh-clinical-psychology.github.io

Interested in human replay and solid methods? Jointly with @skjerns.de we're releasing a benchmark dataset with known ground-truth neural sequences in MEG & fMRI, for developing & validating replay methods. First test: existing methods show similar effect sizes, but room to improve shorturl.at/6TgIr

FASTIMAGES: Validating replay detection methods in human neuroimaging using a combined MEG and fMRI dataset

Studies in rodents and humans using invasive electrophysiology have established that neural replay is a ubiquitous phenomenon in the brain that is associated with a wide range of cognitive functions, ...

shorturl.at

New paper from our group: using simultaneous EEG-fMRI, we investigated the neural mechanisms underlying individual NREM sleep slow waves. Our findings suggest that slow waves are not a homogeneous phenomenon and may reflect distinct physiological processes. www.nature.com/articles/s42...

Thalamic involvement defines distinct slow-wave subtypes in NREM sleep - Communications Biology

Using simultaneous EEG-fMRI, we identify two types of NREM slow waves with distinct thalamic profiles. Large, synchronized waves involve early thalamic activation and arousal markers, whereas smaller ...

nature.com

🔔 Preprint: “Hippocampal ripples evoke a stereotyped cortical response followed by spindle-mediated network synchronization.” Combining iEEG+scalp EEG during sleep, we show that hippocampal ripples leave a decodable cortical fingerprint and are followed by brain-wide spindle synchronization!

doi.org

New paper (with lots of cute animal videos!) Ever watch your dog "run" while asleep and wonder what’s going on in their brain? In Current Bio we suggest that those twitches aren't just leaky dreams—they’re a vital maintenance system for the most precise movements www.cell.com/current-biol...

REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems

Blumberg et al. present video evidence of twitching during adult sleep in a diverse sample of animals. Adult twitching appears to selectively involve appendages used for active sensing, mirroring thei...

cell.com