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Kirmizis Lab

@kirmizislab.bsky.social

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Beckmann Lab@beckmannlab.bsky.social · 5mo ago

How are histones acetylated as they emerge from the ribosome? We show that NAA40 cooperates with the NAC complex to enable co-translational acetylation of H2A/H4, revealing NAC as a coordinator of nascent protein modification. Read more about our collaboration with @kirmizislab.bsky.social #cryoEM

NAA40 and NAC cooperate in co-translational histone acetylation in humans

Nature Communications - N-terminal histone acetylation by human NAA40 alters epigenetic signaling and affects gene regulation. Here, the authors combine biochemistry and cryo-EM to unravel the...

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Kirmizis Lab@kirmizislab.bsky.social · 5mo ago

Pleased to have contributed to this exciting work by @beckmannlab.bsky.social on the mechanism of co-translational acetylation of histones!

Beckmann Lab@beckmannlab.bsky.social · 5mo ago

How are histones acetylated as they emerge from the ribosome? We show that NAA40 cooperates with the NAC complex to enable co-translational acetylation of H2A/H4, revealing NAC as a coordinator of nascent protein modification. Read more about our collaboration with @kirmizislab.bsky.social #cryoEM

Ariel Klavaris@arielchk.bsky.social · last yr.

📢 Our new paper is out! @kirmizislab.bsky.social H2A.X is N-terminally acetylated by NAA40–a novel histone mod responsive to UV irradiation. Thanks to all authors @bonalditiziana.bsky.social @drksquare.bsky.social, anonymous reviewers and @springernature.com #Epigenetics&Chromatin Editorial team.

H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation - Epigenetics & Chromatin

Background N-terminal acetylation (Nt-Ac), mediated by N-terminal acetyltransferases (NATs) is one of the most abundant protein modifications occurring approximately in 80% of all eukaryotic proteins....

epigeneticsandchromatin.biomedcentral.com