Getting ready for our summer school. 16 exiting days of hands on training combined with high profile speakers Looking forward to meet the selected students from 5 continents 🌎! @abcamofficial.bsky.social @helmholtzmunich.bsky.social @epihmgu.bsky.social

There is more to transcriptional readthrough than meets the eye, and it could even provide a therapeutic opportunity in cancer. Check out our new perspective, inspired by recent work from Neugebauer and Grzechnik labs! #RNABiology #RNASky #Epigenetics

Agata Stepien@agatakstepien.bsky.social · last mo.

Studying gene ends is becoming even more fascinating! Curious why? Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication by Podszywałow-Bartnicka and @karlaneugebauer.bsky.social @natsmb.nature.com

Important ! Check this out. Ab-trapping and thus risk of wrong results …. 😢

Konrad Chudzik@konrad-chudzik.bsky.social · last mo.

My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...

Thrilling news to share ... details to come over time, but suffice to say I will have a number of open positions to advertise in the months to come! Skål!!

European Research Council (ERC)@erc.europa.eu · last mo.

The results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch

I really enjoyed the meeting. Great science and interesting discussions. Thanks for the invite !

Brian Strahl@brianstrahl.bsky.social · 2mo ago

What an incredible week it was in Malahide, Ireland, at the FASEB Biological Methylation meeting. It was wonderful organizing this meeting with Capucine Van Rechem, Scott Rothbart, and Tiziana Bonaldi. We had outstanding science and so much thoughtful discussion. Wonderful seeing former trainees!

Excited to announce the International Workshop "Transcriptional memory in health & disease" in Baeza (Spain) this Oct 20-22! Discover how chromatin & networks encode cellular memory with top speakers. unia.es/estudios-y-a... pic.x.com/fjhBUrtRgb

Did you know that Pierre Chambon's laboratory was the first to use the term "nucleosome" in 1975 ? www.cell.com/cell/fulltex...

Sad to hear. Pierre was for 3 years my office neighbour. Lots of memories of interesting discussions (especially on weekends). Pierre was a giant of science. With incredible contributions to multiple fields. 🧬🇫🇷

Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 3mo ago

#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor

EpiCrossBorders Week in Edinburgh was a great mix of collaboration & innovation. Starting with a Biotech Start‑Up Ideation Workshop and ending with a 2‑day symposium engaging PI's and students—we can't believe it is our penultimate year! Still so much to look forward to and achieve #EpiCrossBorders

DEADLINE EXTENDED: Summer School on Chromatin Biology. Transform your knowledge and skills with this 2 week course focusing on ATAC-seq, ChIP-seq, ChIC/CUT&RUN, CUT&Tag, and bioinformatics analyses. Aug 17 - 29 Interested? Apply by April 18 bit.ly/4bZwHHR #abcam #summerschool #phd #helmholtzmunich

Summary - Summer School on Chromatin Biology: A Hands-On Expedition

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Chromatin Summer School 2026. Unique Opportunity 🧪+ 💻 Don’t miss out on it ! Deadline in 2️⃣ days ⬇️⬇️⬇️

Epigenetics at Helmholtz Munich@epihmgu.bsky.social · 4mo ago

Time is almost up! Get your application in now for the Chromatin Summer School 2026. ✅Summer in Munich ✅Immersive lectures ✅Hands on training ✅Networking with leading scientists in the field including @metorrespadilla.bsky.social and @robertife.bsky.social Apply before March 29: bit.ly/4t3Tbyx

Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org

Michela Palamin@mpalamin.bsky.social · 4mo ago

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

⏰ Deadline approaching! Apply now for the Chromatin Biology Summer School 2024 and join an inspiring week of science, learning, and community. Submit before March 29th to be considered for this exciting opportunity: bit.ly/4oGDR8f #chromatin #summerschool

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

Transposable elements are increasingly studied in single-cell data, but how reliable are current locus-level quantification methods in short-read scRNA-seq data? If you work with single-cell RNA-seq or TEs, we hope this is a useful resource — feedback very welcome!

Veronica Finazzi@veronicafin.bsky.social · 5mo ago

Happy to share our new preprint! 📊 We benchmarked methods for locus-level transposable element quantification in short-read scRNA-seq, using both real datasets and simulations with read-level ground truth. Huge thanks to @catavallejos.bsky.social and @antonio-scialdone.bsky.social! #TEsky

Very nice paper from @martingroth.bsky.social at IFE just out !Linking #metabolism and #epigenetics in ➡️ @natplants.nature.com @helmholtzmunich.bsky.social @epihmgu.bsky.social @valentin-ha.bsky.social

Martin Groth@martingroth.bsky.social · 5mo ago

Delighted to share our paper, out today in @natplants.nature.com Not all “wasted” carbon is lost: formate released during photorespiration can be reused to support DNA methylation. Our work reveals a metabolic link between CO₂ levels and epigenetic regulation in Arabidopsis. doi.org/10.1038/s414...

Fellowship application dealdine for students from low income countries 🌐will be in 1️⃣ week. Dont miss out on this opportunity ! Hands on Summer School. Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 15 exiting days ➕ Daily high profile lectures. 👉 bit.ly/4oGDR8f

Summary - Summer School on Chromatin Biology: A Hands-On Expedition

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Helmholtz Munich@helmholtzmunich.bsky.social · 6mo ago

The Epigenetics Community at #HelmholtzMunich, together with #Abcam, is hosting the 3rd #Chromatin #SummerSchool in Munich: 📆 17–29 August 2026 ⏰ Apply by March 29, 2026 👉 Applications & info: bit.ly/4oGDR8f @epihmgu.bsky.social @metorrespadilla.bsky.social @robertife.bsky.social

Dont miss out on it ! Hands on Summer School. Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 14 exiting days ➕ Daily high profile lectures. 👉 Applications & info: bit.ly/4oGDR8f

Helmholtz Munich@helmholtzmunich.bsky.social · 6mo ago

The Epigenetics Community at #HelmholtzMunich, together with #Abcam, is hosting the 3rd #Chromatin #SummerSchool in Munich: 📆 17–29 August 2026 ⏰ Apply by March 29, 2026 👉 Applications & info: bit.ly/4oGDR8f @epihmgu.bsky.social @metorrespadilla.bsky.social @robertife.bsky.social

Great to catch up with alumni @nchoy.bsky.social who stopped by to visit the lab. So great to hear about your internship adventures with @robertife.bsky.social and see you doing so well!

Thanks Rob !

Rob Klose@robklose.bsky.social · 7mo ago

Great story Rob and team. Congratulations all!

Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations

Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...

cell.com

Epigenetics Update - Cell-cycle-dependent repression of histone gene transcription by histone H4 go.nature.com/4bjE521 Kami Ahmad and Steven Henikoff (Fred Hutchinson Cancer Center) reporting in NSMB #Epigenetics #Histones --- Perfect for cancer, immunology, and aging research; epigenometech.com

Excited for this new preprint from my lab where we unexpectedly found a role for methionine synthase reductase in regulating heterochromatin independently of methionine synthesis 👇

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 8mo ago

Methionine synthase reductase regulates heterochromatin independently of methionine synthesis through mitochondrial homeostasis https://www.biorxiv.org/content/10.64898/2025.12.19.695597v1

Thanks Rob !

Rob Klose@robklose.bsky.social · 7mo ago

Nice one Rob and team!

Our new preprint is out: www.biorxiv.org/content/10.6... We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs. A reminder of why bias-aware evaluation matters!

Hidden sampling biases inflate performance in gene regulatory network inference

Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...

biorxiv.org

🎉 Wrapping up 2025 with EpiCrossBorders! A year of breakthroughs, cross-border exchanges, multiple publications & vibrant outreach. Next stop: 2026 Symposium in Edinburgh + new workshops & theses submissions Thank you to all who made this possible. 🌐 #Epigenetics #PhDprogram #Sciencecollaboration

Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations

Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …

sciencedirect.com

👉 Chromatin Summer School 2026 – Apply Now! Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology: 🔬 Expert lectures 🧪 Hands-on training 🤝 Global networking Open to 14 PhD students worldwide (sponsorship available) 👉 Apply here: bit.ly/4oGDR8f #ChromatinBiology

Summary - Summer School on Chromatin Biology: A Hands-On Expedition

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Please RT 📧 Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩‍💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field ! ▶️ shorturl.at/jrA8i