Congratulations 🎉👏 to 🌟 Aleksandra 🌟 @atjanowska.bsky.social for passing her PhD viva today. Many thanks to her examiners, Prof. Jason Carroll and Prof. Jesus Gil for taking the time to assess her work and offer their feedback. We wish her a very successful and bright future ahead 🍀🍀🍀

New study led by Prof. Daniel Munoz-Espin in collaboration with Prof. James Brenton's and our lab 🚨🚨🚨 www.nature.com/articles/s43...

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome - Nature Aging

González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated...

nature.com

A new single-cell multiomics technology from the Ohkawa group, sci-mtChIL-seq, integrating Pol II and TF binding www.nature.com/articles/s41...

Reconstructing epigenomic dynamics through a single-cell multi-epigenome data integration framework - Nature Communications

This study presents a single-cell multi-epigenome framework that uses RNA polymerase II profiles as a reference to reconstruct coordinated chromatin dynamics and transcriptional regulation during cell...

nature.com

The Narita Lab Christmas Dinner 🎄🎁 ❄️ ☃️

Congratulations to Yongmin, who passed his PhD Viva today and many thanks to his examiners, Satomi Miwa and Daniel Munoz-Espin, for their time and enthusiasm!

Congratulations to Aleksandra Janowska who has won our Postgraduate Student Thesis Prize for her work unlocking new avenues for studying the role of cell identity in the origin of cancer. The Prize is awarded yearly to a student undertaking an outstanding project during their PhD study with us.

✨ I’m looking for PhD students in machine learning who are passionate about applying AI to biomedicine to join my lab at the University of Cambridge.✨ More info: www.cruk.cam.ac.uk/vacancies/cr...

Fine-scale chromatin mapping uncovers principles of cis-regulatory element interactions. #NBThighlight www.cell.com/cell/fulltex...

Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions

Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhan...

cell.com

What an honour to have been awarded the CRUK Cambridge Institute Thesis Prize 2025 for my PhD project focusing on chromatin architecture in the @narita-lab.bsky.social at @cruk-ci.bsky.social 🎉 Big thank you to Masashi for allowing me to to this exciting project and the CI community for all support!

Congratulations 🎉 to our PhD student Aleksandra @atjanowska.bsky.social for winning the Best Thesis Prize 🥇. She and Jack (PhD student) presented their work today at the Annual Retreat @cruk-ci.bsky.social We had so much fun with the Team Building, congrats to @hana-aliee.bsky.social for winning! 🏆

🚨 Exciting conference for stem cell aficionados! ‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling. fisci2026.eventbrite.co.uk Please repost 🙏

Frontiers in Stem Cell Innovation 2026

Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery

fisci2026.eventbrite.co.uk

Yesterday our lab group had the pleasure of hosting CRIses, the department-wide social at CRUK. The theme was The Beatles, featuring some of their classic tunes and a Sgt. Pepper-inspired cocktail. Thanks to all who came! 🎸

I'm recruiting ML postdocs to join my lab at the University of Cambridge. Our research focuses on generative modelling, counterfactual reasoning, and sequence modelling to reason about and intervene in complex cellular functions in disease. www.cam.ac.uk/jobs/researc...

Ioana in our lab is participating in the Shine Night Walk Cambridge 10k 2025 tomorrow. Please join/support/share her team page: fundraise.cancerresearchuk.org/team/the-fit... @cruk-ci.bsky.social

The Fit Fellas

Cancer is happening right now, which is why we're fundraising right now for Cancer Research UK. There’s no time to lose! Donate today and help bring forward the day when all cancers are cured. Donatin...

fundraise.cancerresearchuk.org

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇

We are greatly enjoying the exciting science (and location) at ICSA 2025 Rome #ICSA2025Rome @icsasenescence.bsky.social

Tonight, we had a send off dinner for Hiro. We hope you enjoyed your time in our lab and in the UK as much as we enjoyed having you around!

We were honoured to host Prof. Makoto Nakanishi from the University of Tokyo, presenting his work on the senolytic activity of GLS1 inhibition.

Dinner with the two summer students we are hosting and who just presented the results of their hard work to the lab 🧪🧫💻

Introducing Cell Biology to Students from Aichi Prefectural Asahigaoka High School (July 2024 & July 2025) aichi-asahigaoka.ed.jp/news/-Cjth-tx

It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful. Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support

Nature Reviews Cancer@natrevcancer.nature.com · 12mo ago

NEW content online!

👓 Our latest review is out in the Genes&Dev special issue on Aging and Senescence @genesdev.bsky.social released today: The rise of RAS: how gradual oncogene activation shapes the OIS spectrum genesdev.cshlp.org/content/39/1... genesdev.cshlp.org/content/curr...

Only a few days left to apply to join our lab and do exciting senescence research at the University of Cambridge Cancer Research UK Cambridge Institute @cruk-ci.bsky.social @cam.ac.uk 🧪🧬 You can also send informal enquiries (info below): www.jobs.cam.ac.uk/job/52026/ www.jobs.cam.ac.uk/job/52027/

a cartoon character is surrounded by cats and the caption says when someone asks you what your dream job is

ALT: a cartoon character is surrounded by cats and the caption says when someone asks you what your dream job is

media.tenor.com

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - @hagentilgner.bsky.social @liganlab.bsky.social go.nature.com/3IKlcJn

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - Nature Biotechnology

Joint profiling of chromatin and splicing in the brain uncovers shared and distinct patterns.

go.nature.com

A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n

🚨 Big news! The 10th Annual ICSA Meeting is coming to Rome 🇮🇹 on Sept 17-19, 2025! Join us Sept 16th for the 2nd Phaedon Institute-ICSA SenoTherapeutics Summit! 🎟️ Register now—early bird & abstract submissions close June 15! 🔗 icsa2025rome.com #ICSARome2025

ICYMI: New online: scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells

scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells

Nature Structural & Molecular Biology, Published online: 16 July 2025; doi:10.1038/s41594-025-01603-8By leveraging long-read sequencing, single-cell input scNanoHi-C2 systematically delineates chromatin structural reprogramming in embryonic-stage germ cells (EGCs), highlighting the functional importance of three-dimensional (3D) genome structure in mammalian EGC development. This method provides a powerful tool for probing chromatin architecture in individual cells, particularly in rare or precious biological samples.

go.nature.com

🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...

🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work www.nature.com/articles/s41... driven by the brilliant Marialena & Maricarmen with Jörg! @mpi-ie.bsky.social @ethz.ch @natcellbio.nature.com

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

nature.com

#Perspective 🚨 Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease. ⬇️ 📖 https://bit.ly/3IkNY... @moffittnews.bsky.social‬

Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer

In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

bit.ly