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James Gahan

@jgahan.bsky.social

Associate Professor and ERC Starting Awardee at University of Galway! I work on early animal evolution with a particular interest in gene regulation and chromatin! https://gahanlab.com https://chromosome.ie/groups/gahan/ 🏳️‍🌈🇮🇪 He/Him

122 Posts1223 Follower690 Folgt
The Interactive Fly@interactivefly.bsky.social · 2d ago

Chabot, B. J., Sun, R., Amjad, A., ...., Core, L., O'Neill, R. J., Mellone, B. G. (2024). Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape. Genome Biol, 25(1):295 link.springer.com/article/10.1...

Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape - Genome Biology

Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are...

link.springer.com

Al-Sady lab@al-sadylab.bsky.social · last wk.

Took us a bit, but this really special journey is now out, and much improved. Kudos to @agnisrota.bsky.social. It was wonderful to have had to privilege to co-advise you. A showcase of the power of collaboration - a thrill to have worked together on another story with @thebraunlab.bsky.social.

Discrete subdomains establish epigenetic diversity in subtelomeric heterochromatin in fission yeast - Nature Communications

Here the authors show that subtelomeric heterochromatin in S. pombe forms a mosaic of subdomains with distinct requirements for gene silencing and different epigenetic stability, ranging from highly f...

nature.com

Al-Sady lab@al-sadylab.bsky.social · last yr.

Very proud of this story and the amazing Agnisrota Mazumder @agnisrota.bsky.social. An exciting joint journey of exploration with @thebraunlab.bsky.social in subtelomeric heterochromatin. Many surprises but, one that stuck are the unique co-existing epigenetic states in the same domain.

Prof Gavin Yamey MD MPH@gavinyamey.bsky.social · 2w ago

Holy shit FOUR members of the ethics committee in Denmark that gave the green light to allow the widely-condemned RFK Jr-funded trial to proceed in Guinea-Bissau have now resigned in protest This quote is 🔥 Great reporting by @melodyschreiber.com www.theguardian.com/society/2026...

Stig Børsen Hansen, a founding member who was one of two reviewers who presented the study to the Danish committee, resigned from the group in protest on Friday, citing major ethical issues with the study. “You are now enrolling newborns in a lottery to test a hypothesis,” Hansen said. The children who are randomly selected not to receive the birth dose of the vaccine, those who “lost the lottery”, face in their earliest days the risk of contracting hepatitis B, which can cause irreversible lifelong damage. “They contract hepatitis B in the context of being part of a research project,” Hansen said, which made their infection happen, in effect, “by design”. Three other members of the committee have also resigned in protest.
Prof Gavin Yamey MD MPH@gavinyamey.bsky.social · 2w ago

RFK Jr is funding a grotesquely unethical study on newborn babies in Guinea-Bissau; ethicists, pediatricians, clinical trial experts, & infectious disease experts are calling this horrific trial The New Tuskegee. It is unethical to withhold a life saving intervention from half of newborns FFS.

Itai Yanai@itaiyanai.bsky.social · 2w ago

1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research!

Pawel Burkhardt@pawelburkhardt.bsky.social · 2w ago

From bioRxiv to PNAS! 🎉 Very happy to see our paper “Diversity and spatial segregation of TRP channels in the closest relatives of animals” now published in @pnas.org. Another piece in the puzzle of how animal cell signalling evolved. www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Pawel Burkhardt@pawelburkhardt.bsky.social · 4mo ago

How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...

Nobel Prize@nobelprize.org · 3w ago

Peter Hegemann and Georg Nagel – awarded the 2026 medicine prize – discovered a remarkable protein, channelrhodopsin, in a single-celled alga. Hegemann wondered how Chlamydomonas, a single-celled alga, is able to swim towards a light source.

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Rob Klose@robklose.bsky.social · 3w ago

Come join us April 2027 for the next instalment of the EMBL Chromatin and Epigenetics meeting. Great invited speakers and lots of talks selected from abstracts! It will be a fantastic meeting (despite the egregious nucleosome images...)

EMBL Events@events.embl.org · 3w ago

Registration is now open for the EMBL Conference 'Chromatin and epigenetics' 🧬 Explore how epigenetic mechanisms shape human health and disease, and hear renowned speakers discuss the latest advances in the field #EMBLChromatin Submit your abstract by 19 January: s.embl.org/chr27-01-bl

Emma R Andersson@anderssonlab.bsky.social · last mo.

🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Schematic of method developed and application. At embryonic day 7.5, a lentiviral library carrying unique 30-nucleotide barcodes and a fluorescent reporter is injected into the mouse exocoelomic cavity. An E8 embryo cross-section shows that this cavity is continuous with the intraembryonic coelomic cavity, allowing the virus to reach and barcode mesodermal progenitors, including lateral plate and paraxial mesoderm.
Thibaut Brunet@thibautbrunet.bsky.social · 2mo ago

🚨 New preprint alert! 🚨 Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6... A tread 🧵⬇️

Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

biorxiv.org

Teresa Rayon@trayon.bsky.social · last mo.

‼️ Postdoc position open. We study how protein metabolism controls time. If you’re excited by this question, we’d love to hear from you! We’re looking for a motivated & collaborative researcher with a strong track record. 📅 30 September 2026 📢 Please share Apply here 👇👇

Postdoctoral Research Scientist - Babraham

The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

babraham.current-vacancies.com

Marc A. Marti-Renom@mamartirenom.bsky.social · 2mo ago

Latest preprint from the lab… what could be better than good science with good friends? 😊 @agneseloda.bsky.social @antonia-hauth.bsky.social @encent.bsky.social @heard65.bsky.social @heardlab.bsky.social www.biorxiv.org/content/10.6...

X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments

X-chromosome inactivation involves chromosome-wide gene silencing accompanied by extensive chromatin changes, as well the loss of topologically associating domains. Yet discrete regions of the inactiv...

biorxiv.org

James Gahan@jgahan.bsky.social · 2mo ago

Congratulations to all the awardees, its a great achievement. Unfortunate to see Ireland continue to under-perform compared to our potential but @researchireland.ie have unfortunately decided that short-term gains trump a more long-term strategy which could make Ireland a real research powerhouse.

European Research Council (ERC)@erc.europa.eu · 2mo ago

📣 Good news! 📣 Results of the ERC 2026 Starting Grant call are out! Funding worth a total of €705 million will go to 421 early-career researchers across Europe. Discover who, what and where 👉 link.europa.eu/9M3MmN 🧪 #ERCStG #FrontierResearch #HorizonEurope 🇪🇺 @scienceinnovation.ec.europa.eu

Darrin T. Schultz@dts.bsky.social · 2mo ago

I'm thrilled to share that I've started as an Assistant Professor in Biological Sciences and the Oceans Research Center at Lehigh University! I'm building a group in evolutionary genomics to study the origin of animals, and to use those concepts to better understand human disease. More: evogeno.me

Darrin Schultz, a man with curly dark hair and tortoiseshell glasses, smiling at the camera in a brown blazer over a blue patterned shirt with sunglasses hooked on the collar, standing in front of a stone wall.