Thomas Pradeu
@pradeu.bsky.social
CNRS Research Director, Philosophy of Science and Theoretical Biology. Works on Immunology, cancer, and microbiome. CNRS & University of Bordeaux, France.
🎉 Our 25th Anniversary Issue is now live! 🎉🥳 Featuring #Reviews on - 3D tumour atlases - The systemic impact of EVs - Pyroptosis & antitumour immunity #Roadmap on - Early-onset CRC prevention Plus #Viepoints #Comments &#WorldView Check it out 👇 http://dlvr.it/TVcqwv
“Bats are extraordinary among mammals, having uniquely evolved powered flight & laryngeal echolocation, along with disease resistance, extended healthspan & ability to hibernate. With genome assemblies of 103 bat species we provide new insights into evolutionary history & trait diversification.”🦇🧬🙌🧪
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
nature.com
PhilInBioMed@philinbiomed.bsky.social · last mo.Upcoming PhilInBioMed Seminar: September 24 | 5:00–6:30 pm (CET) | hybrid Eve Marder (Brandeis University, USA): “Cryptic (hidden) changes that result from perturbations and environmental change shape future dynamics of degenerate neurons and circuits.” philinbiomed.cnrs.fr/event/eve-ma...
Tomorrow 5pm (UTC+2)! Eve Marder (Brandeis University, USA), “Cryptic (hidden) changes that result from perturbations and environmental change shape future dynamics of degenerate neurons and circuits” (A @philinbiomed.bsky.social event, Hybrid, open to all), philinbiomed.cnrs.fr/event/eve-ma...
This ridiculous number of applications is, in my view, the result of 2 nightmare developments happening concurrently 1.the precariousness of the job market for young PhD graduates which then fuels further: 2.the AI tools enabling overproduction of proposals. #Research #ERC #ResearchFunding #Academia
Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis https://www.biorxiv.org/content/10.64898/2026.09.15.751626v1
Started the day by belatedly reading the excellent essay "Critically assessing atavism, an evolution-centered and deterministic hypothesis on cancer" by Bertrand Daignan-Fornier and @pradeu.bsky.social: doi.org/10.1002/bies... The latter is recruiting a postdoc: philinbiomed.cnrs.fr/jobs/postdoc...
philinbiomed.cnrs.fr
Preprint: Plant pathogens cleave 2’cADPR to suppress TIR immune signaling Inspired by knowledge on how phages inhibit bacterial immunity, we now show that disease-causing bacteria inhibit plant immunity in a similar way. A 🧵 www.biorxiv.org/content/10.6...
Plant pathogens cleave 2'cADPR to suppress TIR immune signaling
Small molecules produced by TIR (Toll-interleukin-1 receptor) domains are essential for plant immune signaling. A central TIR-derived signal is 2'cADPR, a cyclic ADP-ribose (ADPR) molecule that is gen...
biorxiv.org
ICYMI: Nuclear STING compromises replication fidelity
Nuclear STING compromises replication fidelity
Nature Reviews Immunology, Published online: 15 June 2026; doi:10.1038/s41577-026-01324-zA preprint by Teodoro-Castro et al. reports a nuclear role for STING in impairing DNA replication and contributing to replication stress in ageing pathologies.
dlvr.it
Reminder to register for the Unifying Ecology Gordon Conference by next Monday! Lest you miss out on this incredible line up! www.grc.org/unifying-eco... @jennsunday.bsky.social @ewaldoleitao.bsky.social #GRC #ecoevo
Sciences Po, Paris-I, Toulouse : les facs confrontées à des répressions « inédites ». www.mediapart.fr/journal/fran...
Sciences Po, Paris-I, Toulouse : les facs confrontées à des répressions « inédites »
Agression, distribution massive d’amendes, contrôles d’identité… Pour enrayer les mobilisations syndicales et étudiantes, les universités ont de plus en plus souvent recours à la police, aux dépôts d…
mediapart.fr
Many thanks to Markus Kunze, Jérôme Badaut, Muriel Darnaudery, Léa Peltier, Thomas Pradeu @pradeu.bsky.social Isabella Sarto-Jackson and Jan-Pieter Konsman for the great collaboration on this paper! END N=25
Fridolin Gross and @pradeu.bsky.social are advertising a two-year postdoc in conceptual, theoretical, or philosophical approaches to cancer at ImmunoConcept (CNRS & University of Bordeaux, France). Closing 30th July. Sounds amazing! philinbiomed.cnrs.fr/jobs/postdoc...
Postdoctoral Position in Philosophy of Cancer (Bordeaux, France) – philinbiomed
Call for Applications: Postdoctoral Position in Philosophy of Cancer (University of Bordeaux)
philinbiomed.cnrs.fr
Alisa Bokulich@alisabokulich.bsky.social · 5mo agoPostdoc in Philosophy of Cancer at University of Bordeaux, France w/ @pradeu.bsky.social Resume & cover letter w/ brief (2-4 pages) description of your project idea(s) to fridolin.gross@u-bordeaux.fr & thomas.pradeu@u-bordeaux.fr. Application deadline: July 30, 2026 #philsci #philmed #philjobs
'Lower-ranked institutions exhibit higher rates than elite universities, young for-profit publishers show elevated rates vis-à-vis competitors, and academic fields differ widely in adoption. LLM adoption in academic writing is pervasive but socially stratified.' www.pnas.org/doi/10.1073/...
The diffusion of large language models in published academic articles | PNAS
Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. Th...
pnas.org
This is today and this is not to be missed.
PhilInBioMed@philinbiomed.bsky.social · 5mo agoWe are pleased to announce the upcoming PhilInBioMed Seminar: June 8 | 5:00-6:30 pm (CET) | virtual Joan Roughgarden (Stanford University, USA): “Theoretical Microbiology: Holobionts, Lytic/Lysogenic Switch, and Merger vs Major Transition” More Details here: philinbiomed.cnrs.fr/event/joan-r...
Great piece and cover @science.org about how our field is uncovering the evolutionary and mechanistic connections between bacterial and eukaryotic immunity ! www.science.org/content/article/ancient-wars-between-microbes-gave-us-key-immune-defenses
Candidates for California governor discussed housing and insurance policy in the first half of an hourlong debate, then furiously attacked one another at the end.
5 Takeaways From the Last Televised California Governor Debate
Candidates debated housing and insurance policy in the first half, then furiously attacked one another at the end.
nyti.ms
Are all #living things capable of #cognition? Today at 5pm, Mazviita Chirimuuta, an oustanding philosopher of #neuroscience who recently received the #Lakatos Award, will give a hybrid talk that identifies the key features of non-cognitive processes. #philsci #cognitive @philinbiomed.bsky.social
PhilInBioMed@philinbiomed.bsky.social · 6mo agoWe are pleased to announce the upcoming PhilInBioMed Seminar: May 5 |5:00-6:30 pm (CET)| hybrid Mazviita Chirimuuta (University of Edinburgh, UK): “A Mark of the Non-Cognitive” Further details here: philinbiomed.cnrs.fr/event/mazvii... If you wish to join the session, please reach out to us.
Dismissing all members of the National Science Board will only continue the destabilization of American fundamental research and scientific workforce development. Read our statement: brnw.ch/21x1Z8n
Quelques échanges récents ici m’ont donné envie de proposer un panorama de la philosophie des sciences contemporaine. Non pour défendre une corporation, mais pour corriger une image assez datée de la discipline. Je resterai volontairement assez schématique pour ne pas alourdir un thread long. 1/n
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
#OTD in #Phage history: In 1873, the phage therapy pioneer Félix d’Hérelle was born!!! His amazing work at @pasteur.fr and other institutions laid the foundation in which groups like the BBH were founded You can read more about his fascinating life story here www.pasteur.fr/en/institut-...
Exclu Le Parisien : des centaines de médecins, scientifiques et personnalités publient une tribune pro-#vaccination, contre "des idéologies qui manipulent les peurs" : "C'est un bien commun de l’humanité, nous ne laisserons personne la remettre en cause."
Vaccination : le cri d’alarme contre « des idéologies qui manipulent les peurs » - Le Parisien
EXCLUSIF. À l’occasion de la semaine de la vaccination, Le Parisien publie un texte offensif, initié par l’Institut Pasteur et rédigé par de
leparisien.fr
If you are planning to attend, the registration is open. We @hpscambridge.bsky.social are pouring our hearts into this conference and it will be amazing. Even though my own submission was not accepted! #philsci #philsky #hps #metascience
Society for the Philosophy of Science in Practice 2026 Conference | SPSP Cambridge 2026
The Society for the Philosophy of Science in Practice 2026 Conference at the Department of History and Philosophy of Science at the University of Cambridge
spspcambridge2026.com
NAS President Marcia McNutt claims she is being bipartisan by avoiding “topics for which there is a partisan divide.” But this is blatantly partisan. She is doing exactly what one party wants. Worse, in direct opposition to the science in these fields. 🧵1/?
Jeremy Berg@jeremymberg.bsky.social · 6mo agoAbout 42:00 "We have been focusing on topics for which there is NOT a partisan divide"... 2/4
Here’s the head of the National Academy of Science saying that the academies shouldn’t work on climate change or vaccines because of political partisanship, and instead focus on fields with “bipartisan” support like national defense and AI.
Jeremy Berg@jeremymberg.bsky.social · 6mo agoFrom Marcia McNutt's President's Address at the National Academies meeting this morning. www.youtube.com/live/3NXm6d5... 1/4
U.S. President Donald Trump has fired all 24 members of the National Science Board, the body that oversees the National Science Foundation. https://scim.ag/4cxQWhl
Trump fires NSF's oversight board
Dismissal of the National Science Board is widely seen as latest move to erase NSF’s independence
scim.ag
Extinction of the human species: What could cause it and how likely is it to occur?' by Professor Seán Ó hÉigeartaigh (University of Cambridge), on Wednesday 6 May at 6pm UK time. cassyni.com/events/AKmfE...
