Delighted to see this published: H3K115 acetylation is associated with fragile nucleosomes at CpG island promoters and active regulatory sites. Great work from all contributors; Yatendra Kumar, @illingworth-lab.bsky.social @eliasfriman.bsky.social @helink.bsky.social doi.org/10.7554/eLif...

Paper accepted!!!! Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊

Handsup 🙌, who is coming to @blizardinstitute.bsky.social to attend the @illingworth-lab.bsky.social seminar this Friday on "polycomb repression in development and disease"? Also, who is joining online for this @qmulepigenetics.bsky.social seminar.

QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · last yr.

Our next guest speaker webinar is happening on Friday, September 12th at 15:30 GMT. Robert Illingworth will give a talk on 'Passive Yet Essential, Polycomb Repression in Development and Disease’​. To join, please follow this link: qmul.ac.uk/epigenetics/...

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...

CUT&TIME captures the history of open chromatin in developing neurons

Chromatin structure plays a central role in defining cell identity by regulating gene expression. During development, shifts in chromatin structure facilitate changes in gene expression needed to spec...

biorxiv.org

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion

Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...

biorxiv.org

Our next guest speaker webinar is happening on Friday, September 12th at 15:30 GMT. Robert Illingworth will give a talk on 'Passive Yet Essential, Polycomb Repression in Development and Disease’​. To join, please follow this link: qmul.ac.uk/epigenetics/...

Terrific to be involved in Edinburgh's 2025 line-up. Thanks to all of the organisers of @pintofscience.uk and the Monkey Barrel for making this such a great event.

Institute for Regeneration and Repair@edinuni-irr.bsky.social · last yr.

Last night's Pint of Science featured Dr Reynolds-Wright discussing male contraception, while Simran Kapoor explored the role of mast cells in immune responses. At the Monkey Barrel, Dr Illingworth focused on epigenetics & brain development. #pint25 @pintofscience.uk🍺 🧠 📰 edin.ac/3H1qnE1...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions! Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease: www.nature.com/articles/s41...

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model - npj Parkinson's Disease

npj Parkinson's Disease - Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

nature.com

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. www.biorxiv.org/content/10.1...

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain

The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...

biorxiv.org