What can scientists learn from the brains of centenarians? 🧠 @sj-marzi.bsky.social, Dr Alexi Nott & Prof Henne Holstege investigate what makes some people resilient to dementia into old age, in a major new project 👏 ukdri.ac.uk/news-and-eve... @alzheimersresearchuk.org

UK DRI researchers awarded Dementia Frontiers Fund project to study centenarian brains

An international team led by Dr Sarah Marzi (UK DRI at King’s), with Dr Alexi Nott (UK DRI at Imperial) and Professor Henne Holstege (Amsterdam UMC and VIB-KU Leuven Center for Neuroscience) has won £...

ukdri.ac.uk

What can scientists learn from the 🧠 brains of centenarians 💯? @sj-marzi.bsky.social co-leads team EMERALD — asking what protects some people's brains from #dementia. www.kcl.ac.uk/news/what-ca... @ukdri.ac.uk @imperialcollegeldn.bsky.social @amsterdamumc.bsky.social @alzresearchuk.bsky.social

What can scientists learn from the brains of centenarians? £1.5m awarded from the Dementia Frontiers Fund | King's College London

Dr Sarah Marzi will co-lead team EMERALD, who have been awarded £1.5m from the Dementia Frontiers Fund to study how some people's brains may be more resiliant to dementia, with the aim to leverage these insights to develop therapeutics.

kcl.ac.uk

We are hiring again! Our lab is looking for an experimental epigenetics postdoc to work on an exciting 3-year ASAP funded research project studying the role of cell type specific epigenetic regulation in response to toxicant exposures and Parkinson's.

The Dementia Frontiers Fund has selected 12 teams to compete for up to £1.5 million each! Led with Gates Ventures, and supported by research partners Robertson Foundation and Alzheimer's Disease Data Initiative, with support from Q Charitable Trust. www.alzheimersresearchuk.org/news/dementi...

Dementia Frontiers Fund backs 12 international teams to tackle the toughest challenges in dementia - Alzheimer's Research UK

The Dementia Frontiers Fund has selected 12 teams to compete for up to £1.5 million each and tackle major unanswered questions in dementia.

alzheimersresearchuk.org

@sj-marzi.bsky.social has been awarded $1.4m from @asapresearch.parkinsonsroadmap.org as part of a $9m international collaboration investigating how environmental toxicants may influence Parkinson’s disease. www.kcl.ac.uk/news/9m-awar... @ukdri.ac.uk #ParkinsonsResearch

$9m awarded to uncover how environmental toxicants influence Parkinson's | King's College London

Dr Sarah Marzi receives $1.4m from a Collaborative Research Network grant awarded by Aligning Science Across Parkinson's (ASAP) to study link between toxicants and Parkinson’s disease.

kcl.ac.uk

Join us! Research Fellow role at UCL @ukdri.ac.uk @uclqsion.bsky.social with me & @sj-marzi.bsky.social studying oligodendrocytes, genetics & epigenetics in ageing & neurodegeneration using multiomics/bioinformatics. Collaboration with Alexi Nott & @rikeshrajani.bsky.social Closing date: 2nd June

Dementia Researcher@dementiaresearcher.bsky.social · 3mo ago

Research Fellow role at UCL @ukdri.ac.uk with @dervissalih1.bsky.social studying oligodendrocytes, genetics and epigenetics in ageing and neurodegeneration using multiomics and bioinformatics. Closing date: 2nd June www.dementiaresearcher.nihr.ac.uk/job/research...

What role do oligodendrocytes play in Alzheimer's? 🔬 We're pleased to support a major new project led by @sj-marzi.bsky.social, @dervissalih1.bsky.social, @nottalexi.bsky.social & @rikeshrajani.bsky.social, to investigate how these cells influence neurodegeneration👉 www.ukdri.ac.uk/news-and-eve...

📻 New podcast alert A huge pleasure to join Dr David Perlmutter on the Empowering Neurologist podcast, to discuss how epigenetic mechanisms in microglia can contribute to neurodegenerative diseases. youtu.be/gUPvxTEVXjs?...

Toxins Rewrite Your Genes (And Trigger Brain Disease) | Dr. Sarah Marzi

YouTube video by DavidPerlmutterMD

youtu.be

📣 Exciting PhD opportunities in our new programme in 🧬Genome Data Science at @kingscollegelondon.bsky.social! Come and work with me and @oliverpain.bsky.social on APOE penetrance and modifiers in #Alzheimer's. Get in touch to discuss and apply by 28 February. www.kcl.ac.uk/research/tar...

Genome Data Science and AI for Therapeutic Target Discovery - King’s Prize Doctoral Programme | King's College London

PhD programme in human genetics, AI and multi-omics to uncover causal biology and accelerate therapeutic target discovery with academic and industry partners.

kcl.ac.uk

Also the speakers Bosiljka Tasic, Gabriel Santpere, @gioelelamanno.bsky.social, @graycamplab.bsky.social, @sarabiz86.bsky.social @gokcegroup.bsky.social @sj-marzi.bsky.social @rongfan8.bsky.social , Jose Atalaya and the computational team, @hjerling-leffler.bsky.social for their amazing talks!

@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS. Get in touch for any questions and apply by 2 December: my.corehr.com/pls/kclrecru...

Delighted to speak at the @microgliaseries.bsky.social on Monday. Everyone welcome to join us online 🧬✨

European Microglia Webinar Series@microgliaseries.bsky.social · 10mo ago

New webinar coming next MONDAY‼️ Sarah Marzi from UK Dementia Research Institute @sj-marzi.bsky.social will be our next speaker on November 3rd. Check all the information in the flyer and add it to your calendar!

❓ How can proteins lead to personalised Alzheimer’s treatment? Discover how Prof @sj-marzi.bsky.social team have been observing changes in the brains microglia and their responses to Alzheimer’s. Read more about Prof Marzi’s work 👉 lnkd.in/e4iaqqq9

UK DRI @ukdri.ac.uk at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s @sj-marzi.bsky.social group to support stem cell culture, assays, and genomic work on neurodegenerative disease. Closing date: 6th October www.dementiaresearcher.nihr.ac.uk/job/research...

Research Assistant: Stem Cell / iPSC work

UK DRI at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s group to support stem cell culture, assays, and genomic work on neurodegenerative disease

dementiaresearcher.nihr.ac.uk

From fellowship heartbreak to rewriting success — stories of resilience in research funding on this week’s podcast. Available to Watch on YouTube now, or wait until Monday to find it in your podcast app. youtu.be/ZbaRKM18hP0?...

Failing Forward: What My Grant Rejection Taught Me

YouTube video by Dementia Researcher

youtu.be

Join us at the FENS Single-Cell & Spatial Omics Winter School with: @sarabiz86.bsky.social @rongfan8.bsky.social @gokcegroup.bsky.social @gioelelamanno.bsky.social @sj-marzi.bsky.social @jplopez-atalaya.bsky.social Ana Falcão Florian Rosenberger Gabriel Baró Bosiljka Tasic Barbara Treutlein

Federation of European Neuroscience Societies - FENS@fens.org · last yr.

🌟 Registration is now OPEN! 🌟 Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬 📍 Alicante, Spain 🗓️ 11-17 Jan 2026 🔗 https://loom.ly/RM55lFQ

☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions! Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease: www.nature.com/articles/s41...

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model - npj Parkinson's Disease

npj Parkinson's Disease - Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

nature.com

Cells in key brain regions involved in Parkinson’s retain a ‘memory’ of pesticide exposure that disrupts gene expression🧬 Research by @sj-marzi.bsky.social & colleagues unlocks understanding of the mechanisms behind the role of pesticide exposure in Parkinson’s👉 buff.ly/1F16eUB

Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.

Really excited to speak at the Canadian Conference on Epigenetics. Join us in beautiful Banff in November 👇🏻

Canadian Epigenetics@ceehrc.bsky.social · last yr.

Registration is now OPEN for the 11th Canadian Conference on Epigenetics! The annual meeting will be held November 12-15, 2025 at the Banff Centre in Banff, Alberta. You can register and find out more information at our website: event.fourwaves.com/ceehrc2025

Excited to share that a chapter of my PhD has just been published in Nature Communications! We profiled the transcriptomic and chromatin landscapes of microglia expressing the different APOE variants, which were xenografted into the brains of an Alzheimer's disease (AD) mouse model 🧠🧬 1/n

The APOE gene is a major genetic risk factor for Alzheimer's, but different versions of the protein confer strikingly different risk profiles. New research led by ‪@sj-marzi.bsky.social‬ offers insight into how the different versions of APOE affect microglia👉https://buff.ly/pyFh7jy

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @natcomms.nature.com today: www.nature.com/articles/s41... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

So lucky to have the best lab. Will miss @kittybmurphy.bsky.social so much 😢❤️ but excited to see her future successes in ancient genome research!

Kitty Murphy@kittybmurphy.bsky.social · last yr.

And just like that, 5 years in the Marzi lab @sj-marzi.bsky.social have come to an end. Couldn’t have asked for a better team ✨ Super excited to say, I’m switching fields and will be working with ancient human genomes in the Skov lab @lauritsskov.bsky.social in Copenhagen 🇩🇰

Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations across brain diseases👇🏻

Cell Reports Methods@cp-cellrepmethods.bsky.social · last yr.

CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders

Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨

We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders". www.cell.com/cell-reports... @ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders

Murphy et al. develop CHAS, a computational tool that uncovers cell type-specific patterns in bulk tissue histone acetylation data. Applying CHAS to brain disorders reveals distinct cell type targets ...

cell.com

I am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration - Nature Neuroscience

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

nature.com

My FOMO of missing #ADPD2025 is at least partially alleviated by knowing that our team is super well represented by our brilliant PhD student Paulina. Check out her awesome poster on cell type specific histone acetylation in #Alzheimer's disease brain and say hi (poster 160) 🧠🧬

New study by IoPPN researcher Dr Sarah Marzi in @naturecomms.bsky.social offers a new set of guidelines for designing epigenetic studies, based on a new technique, CUT&Tag, which analyse a type of gene regulation mechanism #neuroskyence #AcademicSky www.kcl.ac.uk/news/guideli...

Guidelines on CUT&Tag to study gene regulation

New study compares CUT&Tag to the existing standard of CHIP-seq, serving as guidelines for studying histone modification.

kcl.ac.uk