Amélie Joly

@ameliejoly.bsky.social

Postdoctoral researcher at the @Crick.ac.uk in the lab of @irenemiguel-aliaga.bsky.social| Intestinal physiology, sex differences & metabolism in 🐁| #ForWomenInScience2024 France Young Talent

📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes. www.biorxiv.org/content/10.6...

Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity

Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...

biorxiv.org

What an honour to receive the 2025 Thesis prize of @sneuroendo.bsky.social 🤩 Huge thanks to the scientific committee, to the Fondation Obélisque and to my incredible PhD supervisors @francoisleulier.bsky.social and @filipedevadder.bsky.social 🙏

Filipe De Vadder@filipedevadder.bsky.social · 12mo ago

#ProudPI 🎓 Thrilled to share that @ameliejoly.bsky.social received the thesis prize of the @sneuroendo.bsky.social, huge congratulations! 👏 And @lucasrebiffe.bsky.social is presenting the follow-up of the project in a great poster. Exciting to see the team’s work shining! 💪 #SNE25

2025 Thesis Prize Winner is Amélie Joly

In normally growing juveniles, semaglutide improves glucose control without affecting growth. But in stunted mice, it further impairs linear growth, revealing a key interplay between energy metabolism and the somatotropic axis during development. Mechanistic, not clinical!

Delighted to share that our work has just been accepted in the Journal of the Endocrine Society 🤩 Ever wondered if semaglutide can interfere with growth? Check it out! 👇👇

Filipe De Vadder@filipedevadder.bsky.social · 12mo ago

Our new study, just accepted in the Journal of the Endocrine Society 👉 doi.org/10.1210/jend... We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.

Happy and proud to share this story! 🎉 We show that, when it comes to juvenile malnutrition, sex really matters ♂️♀️🐁 We also uncover a crucial, sexually dimorphic role of FGF21 in these adaptations 💥 👇👇👇

Filipe De Vadder@filipedevadder.bsky.social · last yr.

📢 New preprint: “Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition” Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social. We’re proud to share this story. 👉 www.biorxiv.org/content/10.1...