Bob Gatenby finishes his phenomenal #MathOnco25 talk with this stunning figure and conclusion: "Cycles within cycles may allow metastatic prostate cancer to be converted to a chronic disease". The results are from a new paper: onlinelibrary.wiley.com/doi/10.1002/...
Thursday keynote at #MathOnco25 with @robjohnnoble.bsky.social showing a wealth of #MathOnco models of cancer evolution and evolutionary-enlightened therapies. Notice the bingo card: he showed enough different math models to fill up the card!
Fantastic to have adaptive therapy pioneer Jingsong Zhang here at #MathOnco25 talking about a third-generation adaptive therapy trial for metastatic prostate cancer underway at the Moffitt Cancer Center, informed by Jill Gallagher's mathematical modelling. Preprint: www.medrxiv.org/content/10.1...
First plenary talk at #MathOnco25 today is Harvard's Galit Lahav about the temporal dynamics of p53 and how it lends itself to #MathModeling
Galit Lahav - Wikipedia
en.wikipedia.org
Now at #MathOnco25, co-organiser @gliomath.bsky.social presents recent work showing that the predictions of an AI method massively improved when coupled with a mechnaistic mathematical model www.nature.com/articles/s41...
Biologically informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post treatment glioblastoma - npj Digital Medicine
npj Digital Medicine - Biologically informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post treatment glioblastoma
nature.com
First didactic of the day at #MathOnco25 is Stony Brook's @ceel-damaghilab.bsky.social about the breast ecosystem. The early breast cancer ecosystem is a tumor incubator
Great didactic at #MathOnco25 by @rrockne.bsky.social who starts his presentation with a very Freudian slip by thanking organizers @gliomath.bsky.social and #SINDy (meaning @sandyanderson.bsky.social)
Excited to share our latest on @evoltherapy.bsky.social from Jill Gallaher: PSA/testosterone ratio as a potential biomarker to identify early progressors of adaptive therapy in metastatic castration sensitive prostate cancer @mathonco.bsky.social Read it here: www.medrxiv.org/content/10.1...
Evolutionary medicine holds untapped potential to transform biomedicine & public health. From tackling treatment resistance to understanding disease mismatches, its insights can spark innovation & guide policies for a healthier future. #EvolutionaryMedicine #PublicHealth
Frontiers | The future of evolutionary medicine: sparking innovation in biomedicine and public health
Evolutionary medicine – i.e. the application of insights from evolution and ecology to biomedicine – has tremendous untapped potential to spark transformatio...
frontiersin.org
Todays @mathonco.bsky.social research in progress is from Kasia Rejniak lab member Anna Forero Pinto: Investigating tumor-stroma physicochemical interactions in DCIS microinvasions @moffittnews.bsky.social
Fully-funded PhD opportunity in mathematical biology and applied mathematics with Pascal Buenzli and me at Queensland University of Technology in Brisbane, Australia. Details at smb.org/Member-Forum... @smbmathbiology.bsky.social
🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!! www.nature.com/articles/s41...
A computational pipeline for spatial mechano-transcriptomics - Nature Methods
The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.
nature.com
And now the US gov has started a war on vaccines... kffhealthnews.org/news/article... It's becoming more urgent for Europe to increase funding massively to enable thousands of US researcher to move and continue their research in Europe. @elisabeth-borne.bsky.social @oezdemir.de @fpetit.bsky.social
Scientists Say NIH Officials Told Them To Scrub mRNA References on Grants - KFF Health News
Two senior scientists say National Institutes of Health officials advised them to remove references to mRNA vaccines in grant applications, and they fear the Trump administration will abandon a promis...
kffhealthnews.org
As federal funding for research is uncertain, we need to diversify funding sources for our PhD students. Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies. Download it here: research.jhu.edu/rdt/funding-...
Some action photos from the #StandUpForScience in Tampa this afternoon near the @moffittnews.bsky.social campus including some of your favorite @mathonco.bsky.social people: @sandyanderson.bsky.social @gosiaweh.bsky.social @andriy-marusyk.bsky.social @jillagal.bsky.social and others
Also winning an award this year was our very own @mathonco.bsky.social @cancerevo.org who scooped the Quantitative Science paper of the year along with long term collaborator Conor Lynch @moffittnews.bsky.social More details on the paper here: www.nature.com/articles/s41...
TODAY IS THE DAY! 🧪☀️⬇️ Join us at the Lincoln Memorial or your local site to Stand Up for Science!
My beautiful little sister died two weeks ago from metastatic breast cancer. The idea that anyone thinks they can justify cuts to such research is horrifying to me. I want fewer people to have to experience the pain our family is feeling right now from losing someone so young. #StandUpforScience
Can cancer treatment learn from infectious disease strategies? Our research explores the trade-offs between controlling tumors vs. eradicating them, applying insights from infectious disease dynamics. #CancerResearch #EvolutionaryMedicine
Control vs. eradication: Applying infectious disease treatment strategies to cancer | PNAS
Control vs. eradication: Applying infectious disease treatment strategies to cancer
pnas.org
Some exciting looking science for those of you in London next week
Francesca Ciccarelli@ciccarellilab.bsky.social · last yr.Next Thu 13th March Ilaria Malanchi @ila07.bsky.social and I will host the next "Medicine at the Crick" event focusing on how tissues evolve over time and why this may initiate disease. Free in person/virtual registration @crick.ac.uk: www.eventbrite.co.uk/e/medicine-a...
We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/
Assistant/Associate Professor in Computational Biology - Job Opportunities - University of Cambridge
Assistant/Associate Professor in Computational Biology in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.
jobs.cam.ac.uk
Some good #MathOnco here from our own investigating #Myeloma using a biology-driven #AgentBasedModel
David Basanta@cancerevo.org · 2y agoHot off the press: @mathonco.bsky.social members, including Anna Gaffney, Matt Froid, and yours truly, working with the Lynch lab, use #MathOnco #ABM models to describe the bone ecosystem in Multiple #Myeloma: link.springer.com/article/10.1...
