Tessera
Folgen

Arun Durvasula

@arundurvasula.bsky.social

Assistant Professor in the Center for Genetic Epidemiology and Department of Quantitative and Computational Biology at USC. My lab studies genetics and evolution. https://www.durvasula-lab.usc.edu

32 Posts447 Follower453 Folgt
Jeffrey Ross-Ibarra@jrossibarra.bsky.social · last mo.

Why make the page, I asked @ce7an.bsky.social. Nobody will read it, I said. And here we are, with Cheeto being the most widely read page in the UC Davis High Performance Computing website. hpc.ucdavis.edu/people/cheet...

Dr. Cheeto Cat

Cheeto joined HPC@UCD as a stray scholar-in-residence and has since established himself as a permanent fixture of academic life. Although lacking a formal degree, he has consistently demonstrated exce...

hpc.ucdavis.edu

Chris Fiscus@fiscuscj.bsky.social · 2mo ago

New paper out in PNAS! 🍇🧬 Vitis phylogenomics is a tangled vine. Highlights: • ~14% of the average grape genome comes from introgression • Two classic “hybrid species” are better described as hybrid swarms • Repeated adaptation is fueled by introgression and standing genetic variation

The dynamics of introgression and parallel adaptation across North American Vitis species | PNAS

Hybridization between species can contribute to parallel adaptive events. However, the prevalence of introgression is rarely measured across multip...

pnas.org

Sasha Gusev@sashagusevposts.bsky.social · 2mo ago

Very exciting new method for inferring latent disease trajectories, led by the tireless Dr. Urbut with Natarajan and Parmigiani labs. If you're considering a postdoc in this area talk to Sarah! www.nature.com/articles/s41...

A Bayesian framework for longitudinal EHR and genetic discovery - Nature

A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.

nature.com

Jeff Spence@jeffspence.github.io · 3mo ago

Craig Smail wrote up a really nice Preview of @nikhilmilind.dev's paper where we try to explain why large effect variants tend to affect traits in the same direction on average, which we think about in terms of the non-linearity of gene dosage response curves. www.cell.com/cell-genomic...

Gene dosage differences and non-linear impacts on complex traits

Large differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by ...

cell.com

Jayati Sharma, PhD, ScM@jayatirsharma.bsky.social · 3mo ago

In what has been a labor of love & joyful collaboration, we are super excited to share our preprint on recommendations towards the ethical and accurate use of population descriptors generated from a survey by trainees, for trainees. www.biorxiv.org/content/10.6...

Recommendations for the ethical and accurate use of population descriptors: a trainee-led survey of early-career researchers

Despite the importance of population descriptors in human genomics research, many scientists struggle to translate evolving ethical guidelines into their computational workflows. To characterize this ...

biorxiv.org

Christa Caggiano@christacaggiano.bsky.social · 3mo ago

I'm proud to share our review paper on founder populations in biobanks published recently! It was an extremely cool and humbling process to learn about how important founder populations are in human genetics. I'm glad to play a small part in it www.annualreviews.org/content/jour...

Revisiting Founder Populations in an Age of Global Biobanks

Founder populations have played a pivotal role in human genetics, enabling the discovery of causal variants for disease and providing insight into population history and dynamics. The rapid expansion ...

annualreviews.org

Daniel Swain@weatherwest.bsky.social · 7mo ago

I just submitted my letter to NSF responding to its proposal to dismantle the National Center for Atmospheric Research (NCAR). I argue that doing so would be an astonishing and avoidable misstep, and that federal support for the institution should in fact be *increased.* [1/4]

Page 2 of letter by Daniel Swain. It begins: constructive suggestions regarding how the already remarkable institutional efficiency and societal impact of NCAR could be further enhanced through increased (not decreased) federal support in the years to come. Please note: To ensure the highest level of technical rigor, this response focuses exclusively on the core atmospheric and natural hazard science topics within the author’s primary domain of expertise; for this reason, I have omitted a response to Topic 4 (Space Weather)." NCAR weather modeling and atmospheric observing capabilities a) Management and operations of weather-related observational platforms, modeling and science as a stand-alone activity. The proposed management of weather-related research as a stand-alone activity is a scientifically regressive path that ignores the fundamental physical reality of the Earth system. Modern atmospheric science has demonstrated (largely, it is worth noting, due to groundbreaking researcPage 3 of letter by Daniel Swain. It begins: b) Management and operations of weather-related observational platforms, modeling and science as combined with other NSF investments/facilities. The highly specialized nature of the NCAR-Wyoming Supercomputing Center (NWSC) infrastructure represents an extraordinary value proposition that cannot be replicated by combining it with more generalized NSF programs. The NWSC is not a generic high-performance computing (HPC) facility; it is a laboratory uniquely optimized for atmospheric science workflows, with a hardware and storage architecture specifically designed to handle the massive, high-bandwidth data demands of Earth system modeling. Furthermore, its model of providing an excellent, free-at-point-of-use technical support team ensures that the focus remains on the science rather than the overhead of systems administration. This centralized expertise allows individual researchers, smaller labs, and even entire universities—who would otherwiPage 4 of letter by Daniel Swain. It begins: NCAR Mesa Lab (located in Boulder, Colorado) a/b) Ownership of the NSF NCAR Mesa Lab building for public and private use. Far more than just an office building, NSF NCAR Mesa Lab is an iconic and purpose-built facility designed specifically for the study of atmospheric science. Its position at the physical interface of the Rocky Mountain foothills and the Great Plains is a deliberate reflection of its mission, serving as a visible symbol—in an iconically American setting—of the federal government's enduring commitment to science in service of society. For many in the field, including myself, the Mesa Lab holds singular importance as a focal gathering point for the global atmospheric science community. My own early career exposure to weather and Earth system modeling, in fact, occurred within these walls, and I have long felt that the facility’s architecture and location inspire a necessary sense of awe regarding the atmosphere’s complexity aPage 1 of letter by Daniel Swain. It begins: Dear Acting Director Stone and the NSF NCAR restructuring team: I am writing to provide a formal response to the Request for Information (RFI) regarding the proposed restructuring of the NSF National Center for Atmospheric Research (NCAR) and its critical weather science infrastructure contained within the January 23, 2026 Dear Colleague Letter (DCL) entitled “NSF Intent to Restructure Critical Weather Infrastructure.” I submit these comments in my professional capacity as an atmospheric research scientist within the University of California, where my research focuses on the physics and dynamics of atmospheric processes related to extreme weather events and their role in shifting natural hazard and disaster risk. My perspective is informed by a public-sector career dedicated to bridging the gap between fundamental atmospheric research and real-world application in an academic context, with a particular focus on understanding and mitigating
E.R. Flynn - Cartoonist and Illustrator@erflynncomics.com · 7mo ago

Wheeee! The @americanbystander.bsky.social has posted another Five Pages of Fun for all! #magazine #humor #comics #publishing Best damn humor mag in the US! online.americanbystander.org/five-pages-o...

Five Pages of Fun #003

Almost every Friday we're posting a short, shareable collection of pages from the Bystander's 31 (!) issues. This Friday is no exception, featuring work from Dave Hanson, Adam Koford, River Clegg and...

online.americanbystander.org

Chris Fiscus@fiscuscj.bsky.social · 7mo ago

Excited to share our new preprint! 🍇🧬 We analyzed 639 genomes across 48 grape species to understand how hybridization drives adaptation. • ~14% of average Vitis genome is introgressed • Most parallel adaptations are shared via gene flow • Two "hybrid species" are actually hybrid swarms

biorxiv.org

Nicholas Mancuso@nmancuso.bsky.social · 8mo ago

For folks that have tried both codex (5.3-codex) and claude, what are your thoughts? I've been using codex with some success, but it seems very limited compared to the subagent and plugin capability that claude has.