On this 1st April I'm happy to release a technical report from our startup MirageBio, describing a new protein structure model with state-of-the-art performance. jgreener64.github.io/posts/techni...

@cnrs.fr @cnrsbiologie.bsky.social www.insb.cnrs.fr/fr/cnrsinfo/... Popopopopop @abakamarina.bsky.social @laineelodie.bsky.social Utilisez www.proteocast.ijm.fr ! Et merci à @ijmonod.bsky.social pour l'hébergement de la plateforme

ProteoCast : prédire l'impact des mutations

Comment distinguer, parmi les centaines de millions de mutations ponctuelles possibles dans un génome, celles qui altèrent réellement la fonction des pr

insb.cnrs.fr

📢 ECCB2026 - Call for proceedings now open ! The Scientific Committee welcomes full manuscripts presenting original and unpublished work in computational biology. 🗓 Deadline: 5 March 2026, 1 p.m. CET 🔗 eccb2026.org/call-proceedings #ECCB2026 #Bioinformatics #ComputationalBiology #CallForPapers

📆 Mark your agenda for the 25th European Conference on Computational Biology! It will take place in Geneva, Switzerland, from 31 August-4 September 2026. 👉 Save the date and stay tuned for more updates as we get ready for #eccb2026

Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review! www.sciencedirect.com/special-issu...

** Now seeking postdocs ** Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery. Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.

🚀 As first official act, we are hiring! 🎓 We’re looking for a PhD student to work at the interface of computational biophysics, machine learning & human mutations. 📌 FPI fellowship, 4 years fully funded! More information here: www.bsc.es/join-us/job-...

Gonzalo Parra@gonzaparra.bsky.social · 10mo ago

After months of buildup, it’s finally real! 🎉 The Evolutionary Systems Biophysics Group (ESBG) is officially alive at @bsc-cns.bsky.social . Proud to start this new adventure as a Ramon y Cajal Junior Group Leader🧬 Thanks to all who have been part of this process! tinyurl.com/4r9vf4zx

À l'occasion de la Fête de la Science, plusieurs de nos collections et laboratoires seront ouverts au public ! 📆 RDV les 11 et 12 oct pour visiter nos collections de zoologie, paléontologie et botanique, sans oublier l'ISIR et le @lpnhe-in2p3.bsky.social 👉 Réservez votre ticket : swll.to/4MWnSH0

Si vous avez des adolescentes qui s'intéressent à l'informatique, je signale qu'il reste des places pour les stages #GirlsCanCode en août et septembre. C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie. girlscancode.fr

Very happy to see this out! authors.elsevier.com/a/1lSNA3SNvc... We built upon DANCE dataset to predict protein motions directly from sequences, without exploiting 3D structures! Code: github.com/PhyloSofS-Te....

Elodie Laine@laineelodie.bsky.social · 2y ago

Making protein movies from (sparse) static snapshots! Try out ou method DANCE: github.com/PhyloSofS-Te.... And our PDB-wide analysis of protein conformational variability: www.biorxiv.org/content/10.1.... Joint work with Valentin Lombard and Sergei Grudinin.

research.pasteur.fr/en/call/call...

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research

The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

research.pasteur.fr

Very happy about this collective effort! We provide the community with variant effect predictions for the whole fly proteome. We validated them with annotations, population polymorphism, and CRISPR experiments. Check out your favorite protein with ProteoCast!

Michael Rera@michaelrera.bsky.social · last yr.

Happy to announce the latest preprint of PhD candidate Mariana Abakarova (not yet on bluesky) tinyurl.com/4ewd2v85 in co-supervision with Prof. @laineelodie.bsky.social @sorbonne-universite.fr / @upariscite tinyurl.com/2ntnfvw3 Funded by @agencerecherche.bsky.social ADAGIO and @erc.europa.eu PROMISE

A little discussion with @pierrepo.bsky.social about our MDverse project and its future with the @lumen-eu.bsky.social project (in French). "MDverse, un projet pour explorer les données de la dynamique moléculaire" www.inc.cnrs.fr/fr/cnrsinfo/...

MDverse, un projet pour explorer les données de la dynamique moléculaire

Et s’il était possible de réutiliser les données issues de simulations de dynamique moléculaire pour limiter l’usage des supercalculateurs ?

inc.cnrs.fr

I have two open postdoctoral researcher positions in my group. I am looking for applicants with interest and expertise in computational structural biology and research software development. These positions are part of GANANA, a collaborative European/Indian project Check www.uu.nl/en/organisat...

Postdoc position in computational structural biology

Join our team and contribute to the development of HADDOCK, our integrative modelling software, as part of an exciting EU-India research collaboration.

uu.nl

Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹! www.biorxiv.org/content/10.1... 🧵👇 (1/n)

Have protein-ligand co-folding methods moved beyond memorisation?

Deep learning has driven major breakthroughs in protein structure prediction, however the next critical advance is accurately predicting how proteins interact with other molecules, especially small mo...

biorxiv.org

Cryptic pockets are hidden binding sites in proteins that are not visible in their standard ("apo") structure and only stable in the presence of the right ligand. Here, Bemelmans et al. review how scientists use computer algorithms to detect them. www.sciencedirect.com/science/arti... 🧪 #CompChem

Computational advances in discovering cryptic pockets for drug discovery

A number of promising therapeutic target proteins have been considered “undruggable” due to the lack of well-defined ligandable pockets. Substantial r…

sciencedirect.com

The Rosetta Commons Research Experience for Undergraduates (REU) program accepts applications until February 1, 2025. Apply now and participate in research using the Rosetta Commons software. Learn more here: rosettacommons.org/education/reu/ #REU #RosettaCommons #Undergraduateprogram

Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...

🧪 Got a curious 7–11 year-old at home? 🔍 Whether they’re wondering how yeast grows or want to craft some red blood cells, the new Crick Kids website has them covered! 🎉 Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩‍🔬🔬 👉 Check it out here: kids.crick.ac.uk

Home

We’ve got loads of science experiments, quizzes and crafts for kids and families. Get exploring and see what you discover on Crick Kids.

kids.crick.ac.uk

🚨 I am super happy to announce that our analysis of how the structure of protein-RNA interfaces evolves is now published (early access) at @plos.bsky.social Computational Biology: doi.org/10.1371/jour... 🧬🧶

Structural comparison of homologous protein-RNA interfaces reveals widespread overall conservation contrasted with versatility in polar contacts

Author summary Protein-RNA interactions are crucial to many biological functions and can play a role in diseases. We adopted a computational strategy to analyze and compare experimental 3D structures ...

doi.org

Jessica Andreani@jessicaandreani.bsky.social · 2y ago

Our new preprint! (reposted with tags 🧬🧶) We investigated how protein-RNA interface structure evolves by thoroughly analyzing the conservation of contacts among 2022 pairs of homologous interfaces. Work with Ikram Mahmoudi, Chloé Quignot, Carla Martins

#ICYMI: In a Science study, researchers present “Evo”—a #MachineLearning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Learn more: scim.ag/41bmK6u

Chai-1, the open source AF3 clone, is now available with an Apache 2 license github.com/chaidiscover...

Here is the graphical summary of our findings that helped us to engineer new variants of the protein AstaP that are 51 amino acid shorter than WT yet soluble, express well and bind and transfer carotenoids

Very happy to introduce VespaG, for ultra-fast and accurate prediction of protein mutational effects. github.com/JSchlensok/V.... Big thanks to all authors for the great work and effort. Exciting collab with Rost lab! www.biorxiv.org/content/10.1...

VespaG: Expert-guided protein Language Models enable accurate and blazingly fast fitness prediction

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

Making protein movies from (sparse) static snapshots! Try out ou method DANCE: github.com/PhyloSofS-Te.... And our PDB-wide analysis of protein conformational variability: www.biorxiv.org/content/10.1.... Joint work with Valentin Lombard and Sergei Grudinin.

"Cerebra: a computationally efficient framework for accurate protein structure prediction" presents a structure module without invariant point attention, used in almost all protein structure prediction networks so far (with the notable exception of RosettaFold) www.biorxiv.org/content/10.1...

Join the RCSB PDB Team and transform research and education around the world Open positions include Data Science Workflows Architect, Backend Software Engineer, Senior Front-End Web Developer, and more Details at RCSB PDB: www.rcsb.org/pages/jobs

RCSB PDB: Join the RCSB PDB Team

The RCSB PDB creates tools and resources for research. Participate in exciting projects with significant impact on the scientific community.

rcsb.org

1/n I'm thrilled to share *Deep generative modelling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders* t.co/DoN4DrSFbS from a wonderful collaboration between the Marks Lab and Dias and Frazer group, with @roseorenbuch as lead! 🧵:

New in Science with @jaescudero.bsky.social . A combinatorially complete fitness landscape with >260.000 E.coli genotypes shows unexpected properties. Despite ~500 fitness peaks in this landscape, adaptive evolution can easily navigate to highest fitness peaks www.science.org/doi/10.1126/...

Update on the Chroma vs RfDiffusion analysis. ProteinMPNN just doesn't like Chroma's backbones (poor prediction of proteinMPNN generated sequences by ESMFold). Interestingly, Chroma's own sequence design method (which was trained in the context of partially noise backbones) loves it! (1/3)