It’s time for the World Cup final with one of the greatest footballers that may be playing his last cup So time for a short thread on a link between Messi and an intrinsically disordered protein. 1/n
Gonzalo Parra
@gonzaparra.bsky.social
Ramón y Cajal Junior Group Leader @BSC_CNS 🇦🇷🇪🇸🏳️🌈 ENFJ | Bioinformatics | 3DSIG Co-Chair | @fi_uner, @exactas_uba, @mpi_bpc, @embl, @dkfz alumnus | @iscb BoD | Opinions my own
Could molecules from long-extinct species help fight #antibioticresistance? Researchers are exploring #MolecularDeextinction to uncover novel #antimicrobials, including #peptides from the #extinct moa. A PNAS Core Concept piece: https://ow.ly/hxAy50Z6fHF #evolution #genome
📢 #KRAS degradation induces rapid lung #cancer regression in preclinical mouse models: A study by #IRBBarcelona & @ciccancer.bsky.social demonstrates that eliminating mutated KRAS protein using #PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma. ➡️ https://bit.ly/4dFWhm1
Forgot spike-ins in your lrRNA-seq experiment? 😅 No problem! Our TUSCO benchmarks your transcript models using endogenous single-isoform genes as internal ground truth. Integrated in SQANTI3 for human & mouse. 🧬 Just out in @natcomms.nature.com @pacbio.bsky.social @nanoporetech.com rdcu.be/fkZCb
TUSCO: benchmarking transcriptome reconstruction with endogenous single-isoform controls
Nature Communications - Long-read sequencing enables comprehensive transcriptome characterization but remains challenging to benchmark due to sequencing errors, sample variability, and the limited...
rdcu.be
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
I am writing my first review as a last author without collaborating with any of my previous mentors. Scary... I feel like moving alone far from my parents for the first time 😅
Please, don't write cover letters with AI when applying to jobs. Selection committees see so many of them in a short time window and artificial constructions become too evident. I prefer an honest cover letter with grammar errors, made with effort, rather than a fake one.
On this 1st April I'm happy to release a technical report from our startup MirageBio, describing a new protein structure model with state-of-the-art performance. jgreener64.github.io/posts/techni...
MirageBio technical report
jgreener64.github.io
Paper accepted in my inbox. WooHoo! It never, ever, gets old. Another brick in our edifice of knowledge of life and the universe, and I helped craft this brick.
Atlas of predicted protein complex structures across kingdoms www.nature.com/articles/s41... www.biopredictnavigator.cn
Atlas of predicted protein complex structures across kingdoms - Nature Communications
Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,67...
nature.com
🔬 El #CSIC es el mayor organismo científico de España, con 124 institutos 👩🔬👨🔬 Sus equipos realizan investigación básica para ampliar las fronteras del conocimiento Repasa aquí las noticias destacadas de esta #SemanaCSIC 👇📹🧵
"genAI can be used to create podcasts from a paper to teach st-" Let me stop you right there. Before you feed somebody's paper to a slop machine, invite that somebody to talk to your students about their paper. We're right here. We academics won't shut up about our work, man. 🧪
🚨 New postdoc opening in my group at @bsc-cns.bsky.social! We’re looking for someone excited about protein evolution, local frustration, ML, & large-scale computational biophysics 🧬 Access to world-class HPC (MareNostrum) + great team! www.bsc.es/join-us/job-...
158_26_LS_ESB_R2
Reference: 158_26_LS_ESB_R2 Job title: Postdoctoral Researcher – Protein Computational Biophysics (R2) About BSC The Barcelona Supercomputing Center - Centro N
bsc.es
Are protein–ligand models moving beyond memorization? 🤔 & what does physically informed deep learning really mean for drug design? Find out more about the webinar & register in this link: 👇 elixir-europe.org/events/3d-bi... 🎤 Janani Durairaj 🎤 Markus Lill 📅 April 15 | 17:00 CET
🧩 Just out in Bioinformatics Advances: "Deciphering cis-regulatory elements using REgulamentary" Read the full paper here: https://doi.org/10.1093/bioadv/vbag079
📣 Reminder: #ISMB2026 is accepting abstracts for talk and poster presentations until Thursday, April 9, 2026. 📥 Submit here: https://www.iscb.org/ismb2026/call-for-submissions/abstracts
Today!!! Register and attend by using the links in the post below!
ELIXIR Europe@elixir-europe.org · 5mo ago✨ The next #ELIXIR_3DBioInfo webinar will focus on computational #biophysics. 🗓️ 10 March 2026 | 🕔 17:00-18:00 CET Join the webinar to hear the recent activities in the Community, including dark energy in functional #protein and fold-switching behaviour of RfaH. 👉 https://loom.ly/ctFNLug
✨ The next #ELIXIR_3DBioInfo webinar will focus on computational #biophysics. 🗓️ 10 March 2026 | 🕔 17:00-18:00 CET Join the webinar to hear the recent activities in the Community, including dark energy in functional #protein and fold-switching behaviour of RfaH. 👉 https://loom.ly/ctFNLug
New webinar! March 10th 5pm CET/4pm UK! Exciting computational biophysics! 1) Ezequiel Galpern from @crg.eu Dark Energy in Proteins! 2) Cesar Ramirez Sarmiento (@cxarramirez) from Pontificia Universidad Catolica de Chile! Metamorphic Proteins! Register: elixir-europe.org/events/3d-bi...
New webinar! March 10th 5pm CET/4pm UK! Exciting computational biophysics! 1) Ezequiel Galpern from @crg.eu Dark Energy in Proteins! 2) Cesar Ramirez Sarmiento (@cxarramirez) from Pontificia Universidad Catolica de Chile! Metamorphic Proteins! Register: elixir-europe.org/events/3d-bi...
Nice editorial! "Protein dynamics prediction by integrating biophysics and artificial intelligence" sciencedirect.com/science/arti...
Finally out! Miriam's 1st, 1st author article! 1st last author paper as a group leader! A work that started 3 years ago when I was a postdoc in Alfonso Valencia's group 🥹 doi.org/10.64898/202... Thread🧵
By 2028, all 4-character PDB IDs will be exhausted. After that, all new entries will receive extended IDs: 12 characters total, formatted as pdb_ + 8 alphanumeric characters (pdb_1000axyz) Test it from PDB Beta Archive Read more: www.wwpdb.org/news/news?ye...
Finally out! Miriam's 1st, 1st author article! 1st last author paper as a group leader! A work that started 3 years ago when I was a postdoc in Alfonso Valencia's group 🥹 doi.org/10.64898/202... Thread🧵
FrustrAI-Seq predicts local energetic frustration from sequence alone. ProtT5 with LoRA fine-tuning trained on ~1M proteins analyzes the human proteome in 17 min, extracting physical energy constraints embedded in evolutionary statistics and enabling de novo protein design. doi.org/10.64898/202...
FrustrAI-Seq: Scaling Local Energetic Frustration to the Protein Sequence Space [new] direct sequence-based prediction of local frustration using pLM embeddings enabling analysis of diverse protein regions without structural data.
