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Amélie Freal

@ameliefreal.bsky.social

Assistant Professor @AmsterdamUMC. Neuroscientist and Cell Biologist, AIS aficionado, cytoskeleton fan, Mum of 2 and food lover! https://fga.cncr.nl/research_teams/axon_initial_segment_biology/

21 Posts359 Follower146 Folgt
Kevin Bender@neurobender.bsky.social · 2y ago

@pjenkinslab.bsky.social and I wrote a review on the axon initial segment. We tried our best to discuss the state of the field and provide our perspective (and resolution for) some current sticking points. Hope it's useful! doi.org/10.1152/phys...

Axon Initial Segment Structure and Function in Health and Disease | Physiological Reviews

At the simplest level, neurons are structured to integrate synaptic input and perform computational transforms on that input, converting it into an action potential (AP) code. This process-converting synaptic input into AP output-typically occurs in a specialized region of axon termed the axon initial segment (AIS). The AIS, as its name implies, is often contained to the first section of axon abutted to the soma and is home to a dizzying array of ion channels, attendant scaffolding proteins, intracellular organelles, extracellular proteins, and, in some cases, synapses. The AIS serves multiple roles as the final arbiter for determining if inputs are sufficient to evoke APs, as a gatekeeper that physically separates the somatodendritic domain from the axon proper, and as a regulator of overall neuronal excitability, dynamically tuning its size to best suit the needs of parent neurons. These complex roles have received considerable attention from experimentalists and theoreticians alike. Here, we review recent advances in our understanding of the AIS and its role in neuronal integration and polarity in health and disease.

doi.org

Amélie Freal@ameliefreal.bsky.social · last yr.

We are recruiting!! If you are looking for a post-doc (ephys, slice imaging) or a PhD position (molecular neuroscience), are interested in Axon Initial Segment plasticity and want to join a nice team in a great environment, have a look! And, that's us 👇

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Esther Klingler@estherkli.bsky.social · 2y ago

📣 Postdoc opportunity ! Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗 klinglerlab.org Please share with your network 🙏

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Carmen Sandi@carmensandi10.bsky.social · 2y ago

The ALBA Network is now in bluesky You can follow us here: @network-alba.bsky.social & Time to nominate for several open prizes. One here.

ALBA Network@network-alba.bsky.social · 2y ago

🌟 It’s time to nominate a scientist who made outstanding contributions to promoting #diversity, #equity and #inclusion in neuroscience. This year, ALBA and the FENS-Kavli Scholars are targeting Europe-based students & PIs. Winner announced @ #FRM2025 (Norway, 16-19 Jun) 👉🏾 loom.ly/elEwkCE 📅 19 Dec

Renaud Poincloux@renaudpoincloux.bsky.social · 2y ago

Dear blue-friends, I have just learnt that, due to a cold and brutal administrative decision completely beyond my control, we have to terminate the contract of one of my PhD students, who was recently recruited for a project in cellular mechanobiology 😲. Thread ! 👇