Come and join our team @humantechnopole.bsky.social! We are recruiting a Senior Technician. You will be part of a collaborative and diverse team working on human stem cell biology, precise genome-engineering, and virology. More info: careers.humantechnopole.it/job/Senior-T... Please share.

📣🧠 We're looking for someone to join the Lancaster Lab family as a Research Support Officer (maternity cover). You'll be studying the origins of human brain specialisations using brain organoids, as part of a great team at one of the world's great research environments. mrc.tal.net/vx/mobile-0/...

Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons. Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)

EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...

Developmental timing across species: From mechanisms to evolutionary insights

Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…

meetings.embo.org

In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is! Led by the extraordinary @felinewlindhout.bsky.social www.biorxiv.org/content/10.1...

Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths

The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...

biorxiv.org

A superb review with the latest insights on the Axon Initial Segment from @ameliefreal.bsky.social & Casper Hoogenraad, was a joy reading this 😀

Amélie Freal@ameliefreal.bsky.social · 2y ago

Everything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...

A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience Thanks @frantecol.bsky.social for putting this together. Especially relevant for these dark days for USA science🧪

Franciska de Vries 🟥@frantecol.bsky.social · 2y ago

On #InternationalDayofWomenandGirlsinScience let me remind you that we are NOWHERE NEAR parity. A few examples. 1. Women are credited less in science than men. www.nature.com/articles/s41...

New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵] 🧪🧠🧫🧬

Okenve-Ramos, P., Gosling, R., Chojnowska-Monga, M., Gupta, K., Shields, S., Alhadyian, H., Collie, C., Gregory, E., Sanchez-Soriano, N. (2024). Neuronal ageing is promoted by the decay of the microtubule cytoskeleton. PLoS Biol, 22(3):e3002504 journals.plos.org/plosbiology/...

Neuronal ageing is promoted by the decay of the microtubule cytoskeleton

Aging is associated with structural and functional changes in neurons thought to drive motor, sensory, and cognitive impairments. Using a Drosophila model of aging, the authors report that deteriorati...

journals.plos.org

We just published a thing! In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function. www.nature.com/articles/s41...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

nature.com

Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.630576 We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881 🧵 (1/n)

Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths

The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...

doi.org

Excited to reconnect with old science friends and meet new ones here on Bluesky! I study human neuron development using brain organoids, other in vitro models, and lots of microscopy 🧠🔬