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Ester Hammond

@hammond-lab.bsky.social

Cancer biology Prof at Oxford University, focused on the biological response to hypoxia including replication stress, UPR and transcription

11 Posts1935 Follower518 Folgt
University of Oxford Department of Oncology@oncology.ox.ac.uk · 4mo ago

🆕New research from the @hammond-lab.bsky.social The team demonstrate that TPM3 is a hypoxia-inducible gene in TNBC that supports F-actin organisation. TPM3 loss impaired motility & invasion in hypoxic TNBC cells, while not affecting viability, underscoring its potential as a therapeutic target.

HIF-1–regulated TPM3 links hypoxia to motility and invasion beyond the hypoxic fraction in triple-negative breast cancer - npj Breast Cancer

npj Breast Cancer - HIF-1–regulated TPM3 links hypoxia to motility and invasion beyond the hypoxic fraction in triple-negative breast cancer

nature.com

University of Oxford Department of Oncology@oncology.ox.ac.uk · 4mo ago

Researchers have developed a novel OXPHOS inhibitor designed to reduce tumour hypoxia, a major cause of radiotherapy resistance. By reducing oxygen consumption in tumour cells, the compound increases oxygen availability within tumours, alleviating hypoxia & potentially increasing radiosensitivity.

New compound developed to target hypoxia by reducing tumour oxygen consumption

Researchers have developed a promising new compound designed to reduce tumour hypoxia, a major cause of radiotherapy resistance.

oncology.ox.ac.uk

Grant Stewart@profstewartlab.bsky.social · 10mo ago

Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert: www.jobs.ac.uk/job/DPH515/senior-research-technician

Senior Research Technician at University of Birmingham

An academic position as a Senior Research Technician is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.

jobs.ac.uk

Conway Group@conway-group.bsky.social · 12mo ago

Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells

Proteolysis targeting chimeras (PROTACs) have helped to establish proximity induction as an exciting strategy in drug discovery, and there are multiple clinical trials focused on this modality. Howeve...

pubs.acs.org

Oxford Cancer@oxfordcancer.bsky.social · last yr.

Join us for our DPhil in Cancer Science Open Day on Tuesday 2nd September at 12:30pm to find out how a DPhil can be the next step in your cancer research career development! Register via our Eventbrite link before 1st Sept⬇️ @oncology.ox.ac.uk @medsci.ox.ac.uk www.eventbrite.co.uk/e/university...

University of Oxford - DPhil in Cancer Science Open Day

Join the Virtual DPhil in Cancer Science Open Day to hear more about Oxford’s world-leading research training

eventbrite.co.uk

Andrew Blackford@andrewblackford.bsky.social · last yr.

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

Conway Group@conway-group.bsky.social · 2y ago

Great to see this collaborative work with @emilyflashman.bsky.social and @hammond-lab.bsky.social on @biorxivpreprint.bsky.social. Using our previously developed hypoxia probes (pubs.acs.org/doi/full/10....) to image hypoxia in plants.

Two Color Imaging of Different Hypoxia Levels in Cancer Cells

Hypoxia (low oxygen levels) occurs in a range of biological contexts, including plants, bacterial biofilms, and solid tumors; it elicits responses from these biological systems that impact their survi...

pubs.acs.org

bioRxiv Plant Bio@biorxiv-plants.bsky.social · 2y ago

Hypoxia-activated fluorescent probes as markers of oxygen levels in plant cells and tissues https://www.biorxiv.org/content/10.1101/2025.02.20.639250v1

University of Oxford@ox.ac.uk · 2y ago

Curious about doing a PhD? 🤔 Join Oxford's research community and work with academic staff on projects in a range of subject areas. UNIQ+ research internships are now open for applications from UK undergraduates from under-represented and disadvantaged backgrounds. More info ⬇️

What is a UNIQ+ Research Internship? | University of Oxford

What is UNIQ+?UNIQ+ Research Internships are designed to provide students from under-represented and disadvantaged backgrounds who are ordinarily resident in the UK with the opportunity to experience

ox.ac.uk

Ester Hammond@hammond-lab.bsky.social · 2y ago

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal

imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...

embopress.org

Aga Gambus@agagambus.bsky.social · 2y ago

Still a month left to apply for one of our fully funded PhD positions in Birmingham, UK. EU / International students welcomed. DNA replication, biochemistry, structural biology. Supportive, multinational team. Please RT (not just ❤️). Thank you!

Aga Gambus@agagambus.bsky.social · 2y ago

Two fully funded PhD opportunities in our lab. Interdisciplinary, DNA replication, cancer research, structural biology… deadlines in early Jan. Open to international students. t.co/WEJJIU4zU4 www.findaphd.com/phds/project...

@keithcaldecott.bsky.social · 2y ago

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk

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Tim Fenton@timfenton10.bsky.social · 2y ago

Ok first post on Bluesky and it’s a science one… New paper out from the lab! APOBEC genes protect us from viral infection but go rogue in cancer. Here we shed new light on how these important genes are regulated, offering clues as to what goes wrong in cancer. www.embopress.org/doi/full/10....

Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma | The EMBO Journal

imageimageAPOBEC3A and APOBEC3B encode DNA editing enzymes with anti-viral roles that generate somatic mutations in cancer. This study provides insight into their expression in healthy and cancerous e...

embopress.org