Cis-regulatory strategies in developmental patterning - a new review written by me and @joadelas.bsky.social is out! We discuss how two distinct cis-regulatory strategies, differential accessibility and differential binding, direct cell fate, and spatial and temporal patterning during development.

Congrats to Dr Haresh Bhaskar on passing his viva! Thanks to Aleks Ponjavic and @ecalder.bsky.social for examining!

Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social chemrxiv.org/engage/chemr...

Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase

O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...

chemrxiv.org

Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells

Proteolysis targeting chimeras (PROTACs) have helped to establish proximity induction as an exciting strategy in drug discovery, and there are multiple clinical trials focused on this modality. Howeve...

pubs.acs.org

PhD position available! #ChemSky #PiSky This project is highly interdisciplinary, using organic synthesis to work towards room-temperature quantum technologies. www.findaphd.com/phds/project... The funding is for Home Fee students, and covers 4 years at the UKRI rate (£22,780 tax free for 2025/26).

a dog wearing glasses and a lab coat looks at a beaker under a microscope

ALT: a dog wearing glasses and a lab coat looks at a beaker under a microscope

media.tenor.com

We’re pleased to announce our latest Emerging Investigators article collection, highlighting work from outstanding early career researchers selected from the chemical biology community. Discover this exciting work, all #openaccess and free to read, at rsc.li/CBEMI24.

Join our lab, as a SLRS/PLRS @crick.ac.uk /KCL -Synthetic Chemist/Chemical Biologist #chemsky #chembio, to lead project, build teams, support and train, collaborating across my group and more widely, driving forward basic+translational science tinyurl.com/4f4zhw9d closes 29/4! 24month, possible extn

PhD opportunity available in my lab @edinuni-irr.bsky.social and @edinburghchem.bsky.social. Developing chemical tools for Ubiquitin-like proteins. 3.5 years and would be a good fit for a molecular sciences (chem/bio) background. tinyurl.com/5h5xz93r #chembiosky

Last call to join our lab @crick.ac.uk /KCL - looking for a Chemical Biologist/Biologist #chemsky #chembio, to lead our chemical biology/biology work, collaborating across my group and more widely, driving forward basic+translational science tinyurl.com/5n8d6ufb closes 2/3! 24month, possible extn.

Postdoctoral Research Associate at King's College London

Recruiting now: Postdoctoral Research Associate on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

tinyurl.com

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

Up to 11 fully funded EPSRC PhD projects in various areas of Chemistry are available (including me!). See the link below. Details of projects can be found in the brochure at the bottom of the webpage. Deadline 14 Feb. tinyurl.com/mu4xmfcp

Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems. www.nature.com/articles/s41...

Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Nature Communications

This paper presents a label-free chemoproteomics platform using data-independent acquisition to profile covalent fragment binding across the human proteome. The platform offers high reproducibility an...

nature.com

Are you a chemist or biologist who wants to do an interdisciplinary #PhD? Want to use mRNA display and super resolution microscopy in the context of neurodegenerative disease? Apply for this EastBio project to work at @edinuni-irr.bsky.social @edinburghchem.bsky.social tinyurl.com/nctx5z4r

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

The annual Royal Society of Chemistry Chemical Biology and Bioorganic Group Forum will be in Bristol next year (18th Feb)! Talks spots are open to new group leaders and postdocs - so get your abstracts in by 8th December! Please share 🙏 🧪 #chemsky www.rsc.org/events/detai...