Bob Coelingh
@bobcoelingh.bsky.social
PhD student at Utrecht University Interested in virology and cryo-EM
Amazing tool to keep track of all your big datasets!! Great to see @simon-alkema.bsky.social is continuing his tomo journey
simon-alkema.bsky.social@simon-alkema.bsky.social · 4w agoReleasing TOMATO, the TOMogram Annotation TOol! A lightweight Python GUI for going through hundreds of cryo-ET tomograms. Flag what's in each one, grade its quality, and end up with a table you can filter and act on. github.com/alkemasimon/...
We have a PhD position at Sanquin Research in Amsterdam involving protein engineering, de novo design and antibody development related to bleeding disorders. Please share this with anybody to whom this may be relevant! 🩸 🧬 🧪 🧫 www.sanquin.nl/en/working-a... www.linkedin.com/jobs/view/44...
Sanquin hiring PhD Candidate: Antibody Therapy for Bleeding Disorders in Amsterdam, North Holland, Netherlands | LinkedIn
Posted 10:24:43 AM. The Division of Research and Lab Services of Sanquin is home to 250 researchers, including over 60…See this and similar jobs on LinkedIn.
linkedin.com
🔎 Assistant or Associate Professor in Virology 📍 @utrechtvirology.bsky.social, Netherlands 🔗 instruct-eric.org/jobs/assista... For these jobs and more, make sure to visit our website: instruct-eric.org/jobs If you have a job that you would like to advertise with us, please get in touch!
Assistant or Associate Professor in Virology - Instruct-ERIC
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
instruct-eric.org
Had a great time hosting @proteincapsid.bsky.social over the past few days. Thanks for the exciting lecture and for sharing your tomography expertise. Until next time!
Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠 www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
uu.nl
"Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells" www.biorxiv.org/content/10.1...
Development of a live-cell imaging assay to elucidate spatiotemporal dynamics of extracellular vesicle fusion with target cells
Cells communicate via extracellular vesicles (EVs) containing functional RNAs, proteins and lipids. Knowledge on the fate of internalized EVs, especially their capacity to fuse with target cell membra...
biorxiv.org
Interested in our recent norovirus NS3 work? 👇 Join us to dig deeper! I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques. 🔗 tinyurl.com/4f3t3aae Please share! 🙏
PhD Candidate in Structural Virology and Antiviral Development
We are seeking a PhD candidate to elucidate the role of AAA+ ATPases in the viral replication cycle as part of the recently funded ERC StG project PicAAA.
tinyurl.com
Daniel Hurdiss@danielhurdiss.bsky.social · last yr.Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...
Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...
Think coronavirus spikes have run out of surprises? Think again. Our latest preprint dives into the highly unusual spikes of marine mammal coronaviruses. www.biorxiv.org/content/10.1... This #cryoEM study was led by @viralfusion.bsky.social, with key contributions from an amazing team.
I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊 "A coronavirus assembly inhibitor that targets the viral membrane protein" www.nature.com/articles/s41... A huge congrats to everyone involved! 🎉
Latest #virology research from the lab! 👇 Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication. www.biorxiv.org/content/10.1...
The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses
Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Apro and 3Cpro have been implicated in these processes base...
biorxiv.org
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant. If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch! Application deadline: January 19th. Please share with your networks 🙏 Job link: tiny.cc/7v33001
Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
tiny.cc
Streamlining segmentation of cryo-electron tomography datasets with Ais pubmed.ncbi.nlm.nih.gov/39704648/
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists
Origins and spread of the vaccine-derived viruses remain mysterious
science.org
Amazing science at the Science for Life meeting in Utrecht. The talk by Julia Mahamid was incredible; it most definitely helped me to secure a poster prize too!
Daniel Hurdiss@danielhurdiss.bsky.social · 2y agoHad a great day at the 10th anniversary Science for Life meeting. My personal highlights were the incredible #cryoET talk from Julia Mahamid, and @bobcoelingh.bsky.social winning a poster prize! 🏆
Excited to share our first preprint of 2024! 🎉 researchsquare.com/article/rs-3... This study focuses on PDCoV, an emerging enteric pathogen. We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies. #virology #cryoEM
Our #TeamTomo adventure continues! 🔬 Here is Bob's first attempt running MemBrain-seg on one of his tomograms 😍 @bobcoelingh.bsky.social
