Tessera
Folgen

C.A.M(Xander)_de_Haan.bsky.social

@xdh.bsky.social

Molecular Virology, IAV, PMV, CoV, RSV, EEHV, Associate professor at Utrecht University.

20 Posts104 Follower182 Folgt
Jessica Pickett@pickettjessica.bsky.social · 7mo ago

Ok folks: have at it

Working Paper — New Historical Evidence on the 'Russian Influenza' of 1889

James Pickett and Jessica Pickett — circulated for comment. Primary source documentation from the Bukharan Archive on the 1889 pandemic.

jamespickett.info

Jessica Pickett@pickettjessica.bsky.social · 7mo ago

Spent this weekend in WV (finally!) dusting off a long overdue collab with my favorite historian re: archival records of disease outbreaks around Bukhara right before the 1889 “Russian flu” pandemic 🦠

Utrecht Virology Lab@utrechtvirology.bsky.social · 6mo ago

Check out the latest #virology research from @xdh.bsky.social! Human respiroviruses prefer α2-3 sialic acid, yet infect the α2-6-rich upper airway. We show they solve this via heteromultivalent binding: using α2-6Sia as auxiliary anchors when α2-3Sia is scarce. 🦠🍬 www.pnas.org/doi/10.1073/...

Paramyxovirus infection driven by heteromultivalent sialoglycotope binding | PNAS

Sialic acids (Sia) on glycoproteins and glycosphingolipids act as receptors for many respiratory viruses, including human influenza A viruses and r...

pnas.org

C.A.M(Xander)_de_Haan.bsky.social@xdh.bsky.social · 10mo ago

Important work that supports the ongoing vaccination trial throughput Europe by the EEHV research group @utrechtvirology.bsky.social @utrechtuniversity.bsky.social #EEHV

Daniel Hurdiss@danielhurdiss.bsky.social · 10mo ago

How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬 Our new preprint identifies Elephant Herpesvirus gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉 www.biorxiv.org/content/10.6...

Nonia Pariente@npariente.bsky.social · last yr.

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis 😎 biology but double whammy for cancer patients www.nature.com/articles/s41... 🧪

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

nature.com

C.A.M(Xander)_de_Haan.bsky.social@xdh.bsky.social · last yr.

New review paper from the influenza group @utrechtvirology.bsky.social together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com doi.org/10.1038/s442...

Virion motility of sialoglycan-cleaving respiratory viruses - npj Viruses

npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses

doi.org

Chlanda lab@chlandalab.bsky.social · last yr.

We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!

Bild
The EMBO Journal@embojournal.org · last yr.

Neutralizing antibodies promote filamentous morphology of #influenza A virus by inhibiting cellular entry and transmission of spherical viral particles  #RefereedPreprint c/o @reviewcommons.org by Petr Chlanda @chlandalab.bsky.social and coworkers www.embopress.org/doi/full/10....

Ed Hutchinson@socialinfluenza.bsky.social · last yr.

There's still time to submit your molecular biology abstracts to this year's #ESWI2025 meeting on #Influenza, #RSV and #SARSCoV2. The ESWI meetings are a brilliant way to see your work in context, as they consider these respiratory viruses all the way from molecular biology to policy...

ESWI@eswinfluenza.bsky.social · last yr.

#ESWI2025 🚀 Extra call for abstracts in Molecular Virology – now open! 🚨 Deadline is 31 July 2025 at 23:59 CET 📢 Don’t miss your chance to contribute — submit now! ➡️ eswiconference.org/abstract-sub...

Yi-Wei Chang@yiweichang.bsky.social · last yr.

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

science.org

Dimitri Drekonja, MD, MS@dimitridrekonja.bsky.social · last yr.

Also - we eradicated rinderpest in 2010 (joining smallpox as only diseases eradicated). Turns out fewer anti-vaxxers among cattle 🤦🏻‍♂️

Infectious Diseases@infectiousdz.bsky.social · 2y ago

Measles likely came from cows (via rinderpest) around the 6th century BCE. For 2,500 years, we didn’t evolve superhuman resistance—children just died. Real protection only came in the 1960s, with vaccines. Our superpower isn’t evolving into superhumans. It’s outthinking pathogens.

T
Thelonevirologist @thelonevirologist.bsky.social · last yr.

Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease journals.asm.org/doi/10.1128/...

Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease | Journal of Virology

There is a great need to better understand correlates of protection (CoP) against influenza A and B viruses (IAV/IBV). In our study, we analyzed paired plasma and nasal swabs from patients presenting ...

journals.asm.org

Ed Hutchinson@socialinfluenza.bsky.social · 2y ago

Do you like doing experiments on influenza virus particles but want them to be super-squeaky clean? Or perhaps you'd like to work with filamentous influenza virions but don't know how? Jack Hirst has the protocol chapter for you: link.springer.com/protocol/10....

Purification of Influenza Virions

This chapter describes basic workflows for concentrating and for purifying influenza virions. It presents several ways in which ultracentrifugation can be used to concentrate influenza virions from th...

link.springer.com

T
Thelonevirologist @thelonevirologist.bsky.social · 2y ago

Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens journals.asm.org/doi/10.1128/...

Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens | Journal of Virology

Avian influenza poses significant economic challenges to the poultry industry and presents potential risks to human health. Understanding the molecular mechanisms that facilitate the emergence of chic...

journals.asm.org

Joost Snijder@joostsnijder.bsky.social · 2y ago

Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes www.nature.com/articles/s41...

Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes - Nature Communications

Structurally convergent antibodies targeting the conserved influenza HA anchor epitope have provided a template for next-generation vaccine development. The authors identified four anchor antibodies e...

nature.com

Veesler lab@veeslerlab.bsky.social · 2y ago

With participation of Jimin Lee, Jack Brown, Risako Gen, @dabiophysicist.bsky.social, Cameron Stewart in our lab & in collaboration with the labs of Huan Yan and Tyler Starr www.cell.com/cell/fulltex...

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

Two coronaviruses related to MERS-CoV, which infect European Pipistrellus bats, have been found to use ACE2 as their receptor. These viruses target an ACE2 surface region distant from those recognized...

cell.com