Johns Hopkins Biology is hiring a tenure-track Assistant Professor in computational genetics and genomics. Applications due Nov. 8th: apply.interfolio.com/194924 In my experience, this has been an incredibly supportive environment to build a lab. Please feel free to reach out with any questions.

Here's the ad for the Genome Sciences faculty positions ap.washington.edu/ahr/position...

Maitreya Dunham@maitreya.bsky.social · 2w ago

Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.

Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.

Happy to share results of the @bat1kgenomes.bsky.social phase 1, providing reference genomes covering 21 bat families. New insights into bat phylogeny, ancestral genome reconstruction, European origin & ancestral echolocation. Great work by a team of 100+ colleagues www.nature.com/articles/s41...

Reference genomes and fossils revise bat family phylogeny and biogeography - Nature

An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

nature.com

“Complete, personalized genomes are now possible for anyone,” says senior author @aphillippy.bsky.social.

Human genome milestone opens door for personalized genomics

The ability to quickly and affordably survey a patient’s entire genome is expected to accelerate research, diagnostics, and precision medicine.

cs.jhu.edu

What can we learn about a single rare variant? Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵

It's time to bring complete genome sequencing to the clinic 🧬🩺 Less than 5 years after first sequencing a human genome from end to end, @khmiga.bsky.social, @aphillippy.bsky.social & the #T2T team are making complete sequencing practical for personalized medicine. 🔗 news.ucsc.edu/2026/09/brin...

NIH grant supports bringing complete genome sequencing from the lab to the clinic

A $2.9 million R01 research award from the National Institutes of Health will support the efforts of engineers at the UC Santa Cruz Genomics Institute to further develop and drive down the cost of com...

news.ucsc.edu

Infertility affects ~1 in 6 people, and up to 30% of cases are unexplained. I am excited to present my postdoctoral work from @toddmacfarlan.bsky.social 's lab, now available as a preprint: tinyurl.com/yync6f2r addressing a possible role for the meiotic gene PRDM9 in infertility 🧵/1

Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a 💯 example of wonderful colleagues building something *together*, not in competition =)

A practical guide to studying genome function using single-molecule genomics

Nature Reviews Molecular Cell Biology - Single-molecule genomics methods are used to study the activity of regulatory factors on individual DNA molecules genome-wide, thereby enabling...

nature.com

Scientists including @aphillippy.bsky.social, @mikeschatz.bsky.social, & @stevensalzberg.bsky.social have reconstructed the complete genome of a real person, a breakthrough expected to advance research, improve the diagnosis of genetic diseases, & make personalized genomics routine in medical care.

Human genome milestone opens door for personalized genomics

The ability to quickly and affordably survey a patient's entire genome is expected to accelerate research, diagnostics, and precision medicine

hub.jhu.edu

Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees.

Harmit Singh Malik@harmitmalik.bsky.social · 2mo ago

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Interested in pursuing a PhD in computer science? Join us next week for a virtual info session! Details here: www.cs.jhu.edu/event/phd-pr...

I am delighted to announce that The Department of Human Genetics at the University of Utah is continuing a multi-year recruiting initiative for multiple tenure-track faculty positions at the rank of Assistant Professor. Please share and consider applying! utah.peopleadmin.com/postings/208...

Dangit but sciencing is fun. Discovered a >>10Mb pericentromeric inversion that looks like it adaptively introgressed and is a massive QTL for disease resistance. Preliminary and could be totally wrong, but holy bleep it's been a fun 90 minutes working this out (we had suspected much of this).

If you are thinking of applying to the @uwgenome.bsky.social PhD program this fall, we have a couple of zoom info sessions set up for Oct 6 and Oct 22. Please register at the link. Our website also has a ton of useful information about crafting your application. www.gs.washington.edu/news/graduat...

🧬 Why do high-quality reference genomes matter? Draft genomes can contain gaps, errors and fragmented sequences — potentially hiding important biology. 💻🧬 High-quality references give us a clearer, more complete picture — and a stronger foundation for discovery. #Genomics #EarthBioGenomeProject

Pangenome coordinates can be complex... Shredtools offers a new approach using exact matches to query pangenome data efficiently. Its tools can extract syntenic regions across hundreds of genomes, making pangenome-scale exploration more accessible. pubmed.ncbi.nlm.nih.gov/42465356/

Navigating the pangenome coordinate system with Shredtools - PubMed

Existing notions of pangenome coordinates rely on hard-to-compute multiple sequence alignments. On the other hand, pangenome-wide exact unique matches (multi-MUMs) can be computed efficiently, and represent conserved stretches of columns in the underlying MSA. We introduce Shredtools, which uses mul …

pubmed.ncbi.nlm.nih.gov

Long-read sequencing reveals pre-meiotic gene conversion in sperm www.nature.com/articles/s41...

Long-read sequencing reveals pre-meiotic gene conversion in sperm - Nature

Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before meio...

nature.com

On our last day, the lab ran a pop-up coffee shop for our NHGRI colleagues, staffed by our own highly experienced baristas Suhani and Serge. Farewell NIH! Thanks for being a great home for the past 11 years 🥲 Watch for our next pop-up at Hopkins once we get properly equipped 😁

Biological Databases are critical infrastructure - not projects. As so much effort is put into harnessing AI to solve all our problems, we are allowing the foundational data resources crumble. Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...

I am delighted to present with @hannespetur.bsky.social our new study on the Icelandic pangenome reference HPRC-ICE. This work goes all the way from pangenome construction to disease association! (1/7) www.nature.com/articles/s41...

An Icelandic pangenome reference - Nature

Newly developed methods enable construction of Icelandic haplotypes and mapping of population-scale short reads to a pangenome by reducing reference bias and improving discovery in low-mappability reg...

nature.com

Our vole preprint is officially published in Cell Genomics @cellpress.bsky.social as part of the T2T special issue! www.cell.com/cell-genomic... Lead author @mabuelanin.bsky.social also built this amazing website that we hope will be a useful resource to the vole community: voles.dennislab.org 🐭

Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding

Abuelanin et al. combine PacBio HiFi with low-coverage CiFi proximity-ligation reads in a single library and sequencing run to generate contiguous, near-telomere-to-telomere, accurately phased diploid...

cell.com

Megan Dennis@mydennis.bsky.social · 7mo ago

Excited so share our newest study using a single-library HiFi-CiFi approach to generate chromosome-scale diploid assemblies of two vole genomes, identifying putative drivers of divergent pair-bonding behavior, namely a prairie-vole-specific duplication of Avpr1a gene, led by @mabuelanin.bsky.social

📢 Applications are now open for the NIH Stadtman Tenure-Track Investigator Program! We're recruiting early-career scientists across all areas of biomedical research for tenure-track faculty positions in the NIH Intramural Research Program. Deadline: Sept 30, 2026. 🔗 tinyurl.com/stadtman26

NHGRI is recruiting genomics oriented researchers through the Stadtman mechanism. It is also open to any kind of research, the goal is to match your interests to an institute. The applications are now open until Oct. 1st. Details below:

🧬 The VGP Phase I preprint is out! 🎉 The Vertebrate Genomes Project has completed Phase I, delivering 816 of the highest-quality vertebrate reference genomes ever produced. Explore this major new resource for vertebrate genomics: 📄 tinyurl.com/VGPphase1 @vertebrategenomes.bsky.social #Genomics

"Filling the holes in whole genomes: A vision for personalized genomics from telomere to telomere" Brief commentary from me, @khmiga.bsky.social, @msikic.bsky.social, Yu Kang and Yafei Mao for the T2T special issue. Why do we need complete genomes? Check it out! www.cell.com/cell/fulltex...

new preprint from our group led by Talleh Almelli -- important for folks doing single cell on malaria parasites or other organisms with hyperdiverse gene families. www.biorxiv.org/content/10.6...

Evaluating the impact of a sample-matched reference genome on single-cell transcriptomic inferences in Plasmodium falciparum

Background Plasmodium falciparum field isolates exhibit genomic variation, including copy number variation and sequence divergence. In contrast, the P. falciparum 3D7 reference genome (Pf3D7) was deri...

biorxiv.org

New issue alert👉https://cell.com/cell/current On the cover: The Telomere-to-Telomere Consortium has finished the complete, diploid genome of a person. The cover is inspired by a karyotype of the chromosomes in metaphase, representing the two haplotypes as different colors.

We are excited to officially share the first fully phased telomere-to-telomere (T2T) reference genome for a songbird! 🐦 www.cell.com/cell/fulltex...

📣😮BIG release in @cellpress.bsky.social today!!! When @khmiga.bsky.social and @aphillippy.bsky.social led the completion of a single human genome in 2022, it was a milestone. Completing them routinely is a revolution. Welcome to a new era for personalized medicine.

Adam Phillippy@aphillippy.bsky.social · 2mo ago

For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]