In a new (ish) preprint, we used CRISPR barcodes to label germline stem cell clones in zebrafish, then tracked their contributions to sperm production for 2 years. Instead of staying stable, individual clones rose, fell, and disappeared over time. www.biorxiv.org/content/10.6...

Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis

Spermatogonial stem cells (SSCs) maintain male fertility, but how their clonal dynamics change with age remains poorly understood. Here, we use in vivo CRISPR barcoding in zebrafish to label SSCs and ...

biorxiv.org

At some point we are going to have to reckon with what percentage of the Thought Leadership we get from this class of people is just drug addiction. Either a lot of credulous reporters have never listened to someone tooted out of their mind go on a monologue or they're afraid to call it out.

Richard Kadrey@richardkadrey.bsky.social · 4w ago

This from the guy who has to hire people to play his video games for him.

I don't think anyone has any idea of how thin the margins are in science. To have funding agencies or private foundations come back on a proposal and ask you to cut 10-20%, or more from a project simply means the work cannot be done. Modular grants have not been adjusted for inflation in >20yrs.

in 2016 Elon Musk said he would build a fully automated factory in Fremont, California for the upcoming Model 3 and he then spent on the order of $2 billion on production lines that didn't work, forcing Tesla to assemble cars by hand in a tent but sure, now he's gonna do it on the moon

Taking my time to really listen and learn from the very valid concerns of the MAHA movement:

Memento (artemis) Morty 🌙@mementomorty.bsky.social · 6h ago

we should hear MAHA out about this they might be onto something

“No single figure proves the case on its own. But category after category, the products and services that rely most on immigrant labor are the ones pulling away from the rest of the economy. That’s a cost with a cause, not a coincidence,” the report says.”

Decision makers in federal, state, and local governments, along with the people charged with shepherding your retirement funds, cannot stop giving this guy as much money as they possibly can.

George Pearkes@peark.es · yesterday

Elon is talking about using robots to build a mass accelerator on the moon in support of an economy 1000x to 1 million times the current earth economy. It's a bad sci fi novel not an earnings call.

Severe Covid leads to persistent viral reactivation, with >10 different viruses noted in the first 40 days after hospital admission. Long Covid was specifically associated with reactivation of latent Anelloviridae virus @nature.com www.nature.com/articles/s41...

Virus reactivation in acute and long COVID-19 - Nature

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

nature.com

Not everything is bad. We still have Assateague.

Finally someone lets the failson of an insane hundred billionaire speak

Steve Herman@newsguy.bsky.social · yesterday

"While I was silent, others were happy to write my story for me. No more." - David Ellison, chief executive of Paramount Skydance www.nytimes.com/2026/08/04/op...

if you see this, quote the energy you bring to Bluesky

Fry's Night Shift

ALT: Fry's Night Shift

static.klipy.com

Dr. Kat Napaaqtuk❄️@napaaqtuk.bsky.social · 2d ago

if you see this, quote the energy you bring to Bluesky

Congratulations to the 2026 ASCB Fellows! ASCB is proud to recognize 15 scientists whose careers have advanced cell biology through outstanding research, leadership, mentorship & service. Meet the 2026 Fellows: https://www.ascb.org/society-news/fifteen-visionary-scientists-named-2026-ascb-fellows/

This should be a really obvious point. In order to NOT see it you need to reframe the entire project of higher education in terms of individual degrees for individual benefit—"human capital" to economists. And yes, there are individual benefits. They accrue after a lot of years of work. But—

When we don't adequately fund public universities, and instead force students to take out loans, what we as a society are really doing is borrowing money from the younger generation—their hard-earned future income—to fund a necessary project that benefits us all: building an educated society.

Mark Copelovitch@mcopelov.bsky.social · 2d ago

1. This is bullsh*t & an epically stupid policy completely detached from any empirical evidence: bsky.app/profile/mcop... 2. We could simply avoid this entire issue by <all together now> Funding. The. Damn. Public. Universities. Like. We. Used. To: bsky.app/profile/mcop...

—the cul-de-sac we have managed to drive this discourse into, where higher education is wholly (or even primarily) about economic benefits that accrue to the individual student, would be unrecognizable to the architects of the public university system in any state, or indeed anywhere in the world.

August already? Time for the July #Technical_Advances! wiki.flybase.org/wiki/FlyBase... Want your paper reporting a new resource, technique, or reagent featured in a future month? Flag it when you #FTYP.

FlyBase@flybase.bsky.social · last mo.

This unbearably hot July day brings the June #Technical_Advances wiki.flybase.org/wiki/FlyBase... As always, if you want your paper with a new resource, technique, or reagent included in an upcoming month, flag it when you #FTYP.

It's a tough job, but literally no one has to do it

I don’t really want to get into this with people who feel this way, but i don’t think this is a good thing! We don’t need to behave this way! It’s not healthy to approach academic discourse as an exercise in harshness!

Get your calendars, because the new 2027 EMBL Annual Poster has arrived: s.embl.org/2027-poster Whether you'd like to enhance your skills in a practical course or engage with the latest research at one of our conferences, we've got you covered. See you at EMBL in 2027! 🙌 #LifeSciences #EMBL

Here's your reminder that writing is a craft; working scientists need to practice it. I'm doing the work this evening. And oh yeah, the book is almost done! I'm writing about stem cells now. Stembryos next! (Alstadt lager and Old Overholt for those playing along at home). #devbiolwriteclub.

Nothing convinced me more of the importance of publicly funded basic research more than my time in industry.

Eugene Vinitsky 🍒@eugenevinitsky.bsky.social · 5d ago

Love this idea that industry should subsidize basic research. Industry famously is great at prioritizing timelines longer than a year or two

there are a lot of philosophical concepts that get egregiously misused out of the seminar room (and in the seminar room, to be fair). but in terms of sheer pernicious misuse "social construct" has gotta be top 5 somewhere and it's not number 5

Scott Bryan@scottygb.bsky.social · last wk.

Channel 4 has announced documentary “The Great ADHD Myth?” It “seeks to determine whether ADHD is a genuine neurodevelopmental disorder, or a social construct.”

Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342

Van Andel Institute (VAI) Graduate School is hiring an Assistant Dean! Please share/send to those you think may be interested or those who may know someone interested. vai.wd1.myworkdayjobs.com/en-US/VAICar...

Assistant Dean - Van Andel Graduate School

Van Andel Institute (VAI), a world-class biomedical research institute, located in Grand Rapids, Michigan, is dedicated to improving human health. We are pioneers in the fight against cancer, Parkinso...

vai.wd1.myworkdayjobs.com

look. nobody here likes paying consultants. but the only alternative is paying *instructors*

Asheesh Kapur Siddique@asheeshks.org · 6d ago

“Harvard paid McKinsey & Company at least $250,000 to consult on the Faculty of Arts and Sciences’ staff restructuring efforts, according to internal documents obtained by The Crimson.” www.thecrimson.com/article/2026...

"guys bob wants to study the venom of the gila monster, what a stupid idea" -- industry, 1990s

Eugene Vinitsky 🍒@eugenevinitsky.bsky.social · 5d ago

Love this idea that industry should subsidize basic research. Industry famously is great at prioritizing timelines longer than a year or two

*everyplace* is trying to build private-sector ties fast there isn't nearly enough private sector appetite to fund science for it to work

Chronicle of Higher Education@chronicle.com · 5d ago

CU Boulder draws 70 percent of its research dollars from government. After federal cuts, the Boulder campus expects more than $60 million less for research — and is trying to build private-sector ties fast. Read what the pivot could mean. https://chroni.cl/4pOqrct

"Here we apply DNA Typewriter, a prime editing-based recorder that writes stochastic symbolic insertions to an engineered genomic TAPE in strictly sequential order, to trace mouse development from zygote (E0) to late organogenesis (E13.5)" www.biorxiv.org/content/10.6...

In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis

The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...

biorxiv.org

arXiv has spun out as an independent non-profit like openRxiv. Today they announce their new CEO and founding Board blog.arxiv.org/2026/07/30/a...

arXiv welcomes inaugural CEO and founding Board of Directors

arXiv welcomes inaugural CEO and founding Board of Directors

blog.arxiv.org