Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Sara Marie Ulv Larsen
@ulvlarsen.bsky.social
MD & PhD with an affection for neurobiologi | Research on #Sleep, #Glymphatics, #BrainFluidDynamics and #BrainPulsations | Based in Copenhagen
Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Sleep pressure propels cerebrovascular oscillations while sleep intensity correlates with respiration- and cardiac-driven brain pulsations https://www.medrxiv.org/content/10.1101/2024.10.16.24315580v1
Sleep pressure propels cerebrovascular oscillations while sleep intensity correlates with respiration- and cardiac-driven brain pulsations https://www.medrxiv.org/content/10.1101/2024.10.16.24315580v1
The waste-clearing flow of cerebrospinal fluid through the brain is driven by cerebrovascular, respi
medrxiv.org
How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien! www.cell.com/cell/abstrac... www.science.org/content/arti...
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠
Influence of the Glymphatic System on α-Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex https://www.biorxiv.org/content/10.1101/2024.09.11.612272v1
Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.
Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code
Choroid plexus free‐water correlates with glymphatic function in Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Choroid plexus free‐water correlates with glymphatic function in Alzheimer's disease
INTRODUCTION Free-water imaging of the choroid plexus (CP) may improve the evaluation of Alzheimer's disease (AD). METHODS Our study investigated the role of free-water fraction (FWf) of CP in AD ...
alz-journals.onlinelibrary.wiley.com