Privileged to present our work @cruk-mi.bsky.social at #Cancer&theHost @cancergrand.bsky.social on how the #microbiome🦠 shapes #immunity💥 long before cancer develops. Inspiring talks from #CarolineDive, #AdrianHayday and @johannajoyce.bsky.social . Thanks to the organisers for a fantastic meeting!

Honoured to speak at #EACR2026 in Budapest on how #HostMicrobiome🦠 interactions shape #CancerImmunity💥 @cruk-mi.bsky.social. Thanks to @yardenasamuels.bsky.social and the organisers, and congratulations to @johannajoyce.bsky.social on becoming President of the #EACR. 🎉 #CancerImmunology #Microbiome

Proud of #SwaraPatel and #EmmaWest for representing the Lab so brilliantly at the 19th International PhD Student Cancer Conference (IPSCC) @nkinl.bsky.social in Amsterdam, delivering an excellent oral presentation and fantastic poster. #CancerImmunosurveillanceGroup @cruk-mi.bsky.social

Had an amazing time speaking at @pintofscience.uk about how the #GutMicrobiome 🦠 shapes #AntiTumourImmunity 💥 Thanks to my #Lab @cruk-mi.bsky.social, the organisers, the speakers, everyone who attended and the #TeamManchester🐝 @lydiabeckeriii.bsky.social @manchester.ac.uk @mcrcnews.bsky.social

Congratulations to Samra Turajlić and Tim Somervaille on their election to the Academy of Medical Sciences! 🎉 Their election reflects the achievements of our scientists, as well as the collaborative research environment and powerful facilities in Manchester that enable our work to benefit patients!

Researchers at the Crick have uncovered how lung tumours can hijack the activity of nearby nerves to weaken the body’s immune response. This research was led by Ya-Hsuan Ho and Giacomo Bregni, with corresponding author Leanne Li. www.crick.ac.uk/news/2026-05...

Nerve signals disrupt immune response to lung cancer

Sensory nerve activity disrupts how immune cells are organised within lung tumours, weakening the immune response.

crick.ac.uk

Delighted that our paper is out @natcancer.nature.com. Research led by Tom Castro-Dopico in partnership with Adendra Therapeutics reporting on a means to increase presentation of antigens from cancer cells. Read it for free at www.nature.com/articles/s43...

Coupling dead cell recognition to Fcγ receptors augments anticancer immunity - Nature Cancer

Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...

nature.com

The Francis Crick Institute@crick.ac.uk · 4mo ago

Researchers at the Crick have found a way to redirect immune cells using F-actin exposed from dead cancer cells, reducing tumour growth in mice. The technique opens new avenues for developing immunotherapy treatments that complement existing clinical approaches. www.crick.ac.uk/news/2026-05...

🚨 We're looking for an Associate Director for Strategy & Partnerships — a pivotal leadership role that will help define how we connect, collaborate, and amplify our impact on a global stage of cancer research! Apply below by 26.05.2026! 👇 www.cruk.manchester.ac.uk/career/mi-26... Salary - ~£80,000

🚨 Open for applications - Director of Scientific Core Facilities & Services! Shape the strategic future of our core facilities and work with leading experts on cutting-edge cancer discovery and translational research 🧑‍🔬🔬🧪 💷 ~£100,000 ⏰ 17.5.2026 Apply 👉 www.cruk.manchester.ac.uk/career/mi-26...

Exciting new research from our Group Leader @sylvaindelaunay.bsky.social and Pierre Close at @universitedeliege.bsky.social shows how modifying a tRNA can alter the immune profile of #melanoma - exposing it to the #ImmuneSystem Read the full story here: www.cruk.manchester.ac.uk/news/new-res...

New Research: TRNA Modification Triggers Anti-tumour Immunity | Cancer Research UK Manchester Institute

New research has uncovered an unexpected way to stimulate the immune system against cancer: by subtly disrupting how tumour cells manufacture their proteins.

cruk.manchester.ac.uk

❗Cross-presentation shapes neoantigen visibility and cancer immunogenicity in #NatureImmunology🤯 www.nature.com/articles/s41... Huge congratulations @drjonlim.bsky.social 🥂 Inspired and so lucky to have you in #Manchester 🐝 Congratulations to #OliverSchulz, @reisesousalab.bsky.social , @crick.ac.uk

Jon Lim, FRCP PhD@drjonlim.bsky.social · 9mo ago

My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵

Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!

The Francis Crick Institute@crick.ac.uk · 9mo ago

Researchers at the Crick have uncovered how certain proteins that become exposed on dying tumour cells can be detected by the immune system, alerting it to the cancer’s presence and prompting an immune response. www.crick.ac.uk/news/2025-12...

🎙️ Enjoyed speaking with Salome Chkheidze, a medical student at Tbilisi State Medical University & journalist at Medscriptum, about precision oncology and the evolving opportunities (and challenges! of cell therapy in solid tumours. Many thanks for the interview feature 👇

Overcoming Barriers to Cell Therapy - From Spatial Immunology to the Scalability Gap - MedScriptum

In this interview, Dr. Lim unpacks the evolving role of cell therapies and reveals the gaps between promise and practice that call for fresh thinking.

medscriptum.org

🎙️ Great to hear Samra @turajliclab.bsky.social and @manifest-cirrp.bsky.social featured on BBC Radio 5 Live 👇

The Francis Crick Institute@crick.ac.uk · 9mo ago

Samra Turajlić and @dremmacbw.bsky.social spoke to BBC Radio 5 Live about some of this year’s medical research advances, including their work on immunotherapy and Long COVID. Listen from 53:10 and 2:46:00 ⤵️ www.bbc.co.uk/sounds/play/...

Hear more about RISE + why tackling safety/toxicity in advanced therapies is centre to our programme. We're humbled to hear from Elkie Mellor, who generously shared her lived experience. Voices like hers are a powerful reminder of why this work matters & will continue to motivate everything we do.

Major study launched to make advanced cancer treatments safer for patients

A major new UK study, led by The Christie NHS Foundation Trust and The University of Manchester, has been launched to help patients with cancer better tolerate cutting-edge immunotherapy treatments li...

christie.nhs.uk

Our Institute Director, Professor Samra Turajlić, will be giving a public talk at @crick.ac.uk 💬Crick Crash Course: Immunotherapy 📅Wed 19th Nov 🕙10am 📌Crick Institute, London For full details and to book: www.eventbrite.co.uk/e/crick-cras... @turajliclab.bsky.social #Immunotherapy

You've got just a few days left to submit your proposal to join us as a new Group Leader 📅 Applications close 2nd November Package includes: 🪙Multi-year funding 🧪Core Facility Access 🥼 #Postdoc & #PhD positions 🤝Mentorship Visit our website to apply: www.cruk.manchester.ac.uk/career/new-g...

🎓 Fully-funded 4-yr MRC PhD @officialuom.bsky.social! Join a world-class team exploring how the microenvironment drives CRS in CAR-T therapy. 🌍 Open globally | 💥 Translational science 🗓️ Apply by 8 Nov 2025 🔗 www.findaphd.com/phds/project... #PhDOpportunity #TeamManchester 🐝 @uom-dcs.bsky.social

We are excited to announce that our #PhD Student Recruitment is open for applications! For full details of all projects and information on how to apply, visit: www.cruk.manchester.ac.uk/phd-student-... 📅 Applications close 28th November & we look forward to hearing from you!

You have just *4 days* left to apply for a #Postdoc position with the fab @sylvaindelaunay.bsky.social Study how diet affects #RNA modifications to drive cancer progression with: 🔵In vivo models 🔵Patient samples 🔵Long-read #Nanopore seq 🔵 #CRISPR screens www.cruk.manchester.ac.uk/career/mi-25...

MI/25/57 Postdoctoral Scientist | Cancer Research UK Manchester Institute

A postdoctoral position is available in the laboratory of Sylvain Delaunay to study how diet affects RNA modifications to drive cancer progression.

cruk.manchester.ac.uk

Exciting news - we are recruiting new Group Leaders! 🥼 We are seeking to appoint exceptional early-career scientists & clinician scientists as #GroupLeaders to develop bold, innovative, high-impact #CancerResearch programmes Full details on our website: www.cruk.manchester.ac.uk/career/new-g...

Group Leader Recruitment at the Cancer Research UK Manchester Institute

YouTube video by CRUK Manchester Institute

youtu.be

Exciting new research from our Cancer Inflammation and Immunity Group led by @santiagozelenay.bsky.social on the counterintuitive effects of steroids to enhance responses to immunotherapy in #melanoma Visit our website for more on this paper published today in Cancer Discovery

Glucocorticoids Unleash Immune-dependent Melanoma Control Through Inhibition Of The GARP/TGF β Axis | Cancer Research UK Manchester Institute

This study uncovers a surprising role for GCs in triggering CD8+ T cell–dependent tumour control through downregulation of GARP and thus TGF β signalling.

cruk.manchester.ac.uk

Now online in Cancer Discovery @aacrjournals.bsky.social: Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGF β Axis - by Charles Earnshaw, @santiagozelenay.bsky.social, and colleagues doi.org/10.1158/2159... @cruk-mi.bsky.social

Just 3 days left to apply for a #postdoc position with @clausjorgensen.bsky.social and the Systems Oncology group 🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...

One great opportunity is for a self-motivated, innovative, meticulous and organised candidate who is keen to work in a dynamic laboratory undertaking cutting edge research with Prof @clausjorgensen.bsky.social as a #PostdoctoralScientist Full details at: www.cruk.manchester.ac.uk/career/mi-25...

MI/25/33_2 Postdoctoral Scientist | Cancer Research UK Manchester Institute

Dr Claus Jorgensen, Group Leader of the Systems Oncology Group, is looking for a Postdoctoral Scientist to join his group. This is a great opportunity for a self-motivated, innovative, meticulous and ...

cruk.manchester.ac.uk

People make places. Proud to be part of #TeamManchester 🐝, and to work alongside inspiring colleagues who consistently go above and beyond - always putting patients first. 🏆 The Christie NHS Foundation Trust @mcrcnews.bsky.social www.bbc.co.uk/news/article...

Best and worst-performing NHS Trusts in England named

Critics question the usability of new league tables meant to inform the public and let them exercise choice.

bbc.co.uk

My "Crash Course in …Immunology" is now posted on YouTube youtu.be/nBC9vvlTxF8. Taken from a public lecture @crick.ac.uk on history and basic concepts in immunity. Aimed at the lay public and those seeking an introductory overview.

The Past, Present and Future of Immunology Research – with Caetano Reis e Sousa

YouTube video by Francis Crick Institute

youtu.be

Delighted that our paper describing cDC1 states and their distribution in mouse tumours is out today in @eurjimmunol.bsky.social. Many congratulations to Cécile Piot who led this work and brought it to conclusion! onlinelibrary.wiley.com/doi/10.1002/...

Thrilled to welcome #SamraTurajlić to the #ManchesterFamily 🐝! We are excited for her vision and leadership in driving world-class, multidisciplinary cancer research, and proud to be part of this journey together!

Cancer Research UK Manchester Institute@cruk-mi.bsky.social · last yr.

Today we are delighted to welcome Professor Samra Turajlić (@turajliclab.bsky.social) as our new Institute Director! Her work - spanning basic, translational & cancer research - has advanced our understanding of cancer biology & treatment Read more here: www.cruk.manchester.ac.uk/news/profess...

I'm deeply honoured to receive the BACR/AstraZeneca Young Scientist Frank Rose Award in recognition of my cancer research. Grateful to @thebacr.bsky.social @astra-zeneca.bsky.social ‬ #Mentors & #Colleagues whose support has shaped this journey. My reflections👇 🔗 www.bacr.org.uk/news/2025-ba...