Max Krummel

@maxkrummel.bsky.social

Prof @ucsf/immunox, co-founder Solvingfor.org, Immunologist,Immunotherapy pioneer,believer in the power of curiosity,striving to make sense of complicated things, typically enthusiastic.

Many tx studies (Mujal... Azizi…)failed to validate M1/M2 signatures in vivo. Many also suspected that calling cells bearing ‘prototypical M2’ genes ‘‘immunosuppressive’ was simplistic + incorrect. Nonetheless many (us too!) leaned on the simplification. Arja addresses the reality head on…thnx JEM

Over 12,000 publications simplified macrophage diversity as’M2-like’in about the past ~18 months (we once did so too!)
Waggoner Lab@labwaggoner.bsky.social · 2y ago

Rather than immune suppression, CD206+ TAMs recruit a tumor-reactive network of CD8 T cells, cDC1s, and NK cells doi.org/10.1084/jem.... @maxkrummel.bsky.social @jexpmed.bsky.social

Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others www.biorxiv.org/content/10.1...

Critical role of CD206+ macrophages in organizing anti-tumor immunity

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