Population-specific transcriptomic shifts underlie secondary metabolic diversification in Aspergillus flavus Link and the domestication of Aspergillus oryzae (Ahlb.)

The genomic signatures of microbial domestication remain poorly understood within the context of natural population variation. Here, we demonstrate that Aspergillus oryzae, the filamentous fungus used...

imafungus.pensoft.net

Dr. Nancy Keller on Mold and Mycotoxins

Podcast Episode · The Life Lab by Death Clock · May 29 · 42m

podcasts.apple.com

doi.org

doi.org

The World's Deadliest Mushroom is Getting Deadlier

YouTube video by SciShow

youtube.com

youtu.be

A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen

Abstract. Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Unders

doi.org

A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen

Abstract. Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Unders

academic.oup.com

network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen

Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Understanding the gene regulatory networks that specify the expression programs underlying this fungus’ diverse phenotypes can shed mechanistic insight into its growth, development, and determinants of pathogenicity. We used eighteen publicly available RNA-seq datasets of Aspergillus fumigatus to construct a comprehensive gene regulatory network resource. Our resource, named GRAsp (Gene Regulation of Aspergillus fumigatus), was able to recapitulate known regulatory pathways such as response to hypoxia, iron and zinc homeostasis, and secondary metabolite synthesis. Further, GRAsp was experimentally validated in two cases: one in which GRAsp accurately identified an uncharacterized transcription factor negatively regulating the production of the virulence factor gliotoxin and another where GRAsp revealed the bZip protein, AtfA, as required for fungal responses to microbial signals known as lipo-chitooligosaccharides. Our work showcases the strength of using network-based approaches to generate new hypotheses about regulatory relationships in Aspergillus fumigatus. We also unveil an online, user-friendly version of GRAsp available to the Aspergillus research community.

sco.lt

Whole-chromosome duplications drive antimicrobial resistance in Aspergillus fumigatus

Aneuploidy causes genome plasticity and enables adaptive responses that confer drug resistance in eukaryotes ranging from fungal pathogens to human cancer cells. Aspergillus fumigatus is a soil-reside...

biorxiv.org

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation

Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...

cell.com

Larval zebrafish burn wound infection model reveals conserved innate immune responses against diverse pathogenic fungi | mBio

Secondary fungal infections within burn wound injuries are a significant problem that delays wound healing and increases the risk of patient mortality. Currently, little is known about how fungi colon...

journals.asm.org