Keller Lab
@kellerlab.bsky.social
Updates from the Nancy Keller Lab at the University of Wisconsin-Madison Fungal genetics, genomics, and secondary metabolism. 🍄 Managed by grad students Website: https://sites.google.com/view/kellerlabuw/keller-lab-home?authuser=0
🍄 New study on #fungal #isocyanide synthases (#ICSs)! With @grantnickles.bsky.social @kellerlab.bsky.social (Uni. Wisconsin-Madison) @currentbiology.bsky.social @unipd.bsky.social Thanks all for the great teamwork! doi.org/10.1016/j.cub.… #Lichens #SecondaryMetabolism #biosyntheticGenes #fungi
Recently, Dr. Keller was featured on the podcast "The Life Lab by Death Clock," where she discussed molds and mycotoxins, and their impacts on the food supply chain. Curious? Listen here: Spotify (urldefense.com/v3/__https:/...) Apple Podcasts (podcasts.apple.com/us/podcast/d...)
Dr. Nancy Keller on Mold and Mycotoxins
Podcast Episode · The Life Lab by Death Clock · May 29 · 42m
podcasts.apple.com
Especially happy to be finishing this project, it taught me so much. doi.org/10.64898/202... Thanks for the journey, @ameliabarberphd.bsky.social and @kellerlab.bsky.social!
doi.org
New preprint day!! @laurafabre.bsky.social took 1k RNAseq samples and built an atlas of lncRNAs across four Aspergillus species, expanding the gene content of each by up to 20% and discovering a novel modulator of aflatoxin production. w/ @kellerlab.bsky.social.
doi.org
Meet Nancy Keller, one of our plenary speakers! Dr. Keller's research focuses on the discovery of secondary metabolite synthases and their chemical products and the intrinsic development of antifungal resistance in Aspergillus pathogens. Register today for #CFN25 to hear more from Dr. Keller.
Remember: All mushrooms are edible, but some are edible only once! 🍄 Our lab's research made it into @hankgreen.bsky.social and @scishow.bsky.social 's latest video on the death cap! Watch it here: www.youtube.com/watch?v=PNL_...
The World's Deadliest Mushroom is Getting Deadlier
YouTube video by SciShow
youtube.com
Keller Lab@kellerlab.bsky.social · 6mo ago☠️🍄The world's deadliest mushroom has been hiding a secondary metabolite secret! The Keller, Drott & Pringle Labs just published in @pnas.org: leaderless RiPPs, a peptide class never before seen in fungi, found in Amanita phalloides and linked to its Californian invasion. www.pnas.org/doi/10.1073/...
So amazing when my morning show/internet role model cites work from my lab! youtu.be/PNL_C3j1C2A?...
youtu.be
Keller Lab@kellerlab.bsky.social · 6mo ago☠️🍄The world's deadliest mushroom has been hiding a secondary metabolite secret! The Keller, Drott & Pringle Labs just published in @pnas.org: leaderless RiPPs, a peptide class never before seen in fungi, found in Amanita phalloides and linked to its Californian invasion. www.pnas.org/doi/10.1073/...
☠️🍄The world's deadliest mushroom has been hiding a secondary metabolite secret! The Keller, Drott & Pringle Labs just published in @pnas.org: leaderless RiPPs, a peptide class never before seen in fungi, found in Amanita phalloides and linked to its Californian invasion. www.pnas.org/doi/10.1073/...
Very happy to see this published: doi.org/10.1093/nar/...: a GRN-based approach to predict regulatory subnetworks for developmental and pathogenic processes in Aspergillus fumigatus and GRAsp: a network viz tool: grasp.wid.wisc.edu with @jeanmichelane.bsky.social and Nancy Keller labs!
A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen
Abstract. Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Unders
doi.org
We are excited to announce the publication of GRAsp, a gene regulatory network prediction tool for A. fumigatus in collaboration with @sroyyors.bsky.social and @jeanmichelane.bsky.social in Nucleic Acid Reports! This tool can be found on our lab website or at grasp.wid.wisc.edu.
A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen
Abstract. Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Unders
academic.oup.com
Latest paper from our lab in collaboration with @sroyyors.bsky.social and Nancy Keller. Most notably for me, we describe here the first fungal gene required for responses to LCOs (Nod factors) in the fungus Aspergillus fumigatus. More to come on this topic later!
network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen
Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Understanding the gene regulatory networks that specify the expression programs underlying this fungus’ diverse phenotypes can shed mechanistic insight into its growth, development, and determinants of pathogenicity. We used eighteen publicly available RNA-seq datasets of Aspergillus fumigatus to construct a comprehensive gene regulatory network resource. Our resource, named GRAsp (Gene Regulation of Aspergillus fumigatus), was able to recapitulate known regulatory pathways such as response to hypoxia, iron and zinc homeostasis, and secondary metabolite synthesis. Further, GRAsp was experimentally validated in two cases: one in which GRAsp accurately identified an uncharacterized transcription factor negatively regulating the production of the virulence factor gliotoxin and another where GRAsp revealed the bZip protein, AtfA, as required for fungal responses to microbial signals known as lipo-chitooligosaccharides. Our work showcases the strength of using network-based approaches to generate new hypotheses about regulatory relationships in Aspergillus fumigatus. We also unveil an online, user-friendly version of GRAsp available to the Aspergillus research community.
sco.lt
Excited to share our new preprint in collaboration with @kellerlab.bsky.social! We identified unstable aneuploidy in Aspergillus fumigatus and explore how aneuploidy-mediated transcriptional and metabolic changes influence antifungal resistance. www.biorxiv.org/content/10.1...
Whole-chromosome duplications drive antimicrobial resistance in Aspergillus fumigatus
Aneuploidy causes genome plasticity and enables adaptive responses that confer drug resistance in eukaryotes ranging from fungal pathogens to human cancer cells. Aspergillus fumigatus is a soil-reside...
biorxiv.org
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation Penicillium solitum over 8 years in a cheese cave => green-to-white shift @currentbiology.bsky.social from @benwolfe.bsky.social with @kellerlab.bsky.social www.cell.com/current-biol...
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...
cell.com
New publication with the Huttenlocher Lab! Led by PhD candidate Nayanna Mercado Soto, we used zebrafish to study burn wound infections with Candida albicans & Aspergillus fumigatus, showing the innate immune response is highly conserved across fungal species. #fungi journals.asm.org/doi/10.1128/...
Larval zebrafish burn wound infection model reveals conserved innate immune responses against diverse pathogenic fungi | mBio
Secondary fungal infections within burn wound injuries are a significant problem that delays wound healing and increases the risk of patient mortality. Currently, little is known about how fungi colon...
journals.asm.org