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Daniel Lüdke

@danielluedke.bsky.social

🌱Plant Biologist🌱 Post-doc @thesainsburylab.bsky.social | he/him

1 Posts781 Follower187 Folgt
Camilla Molinari@camilla-moli.bsky.social · 4w ago

Excited to share this pre-print from my PhD work! We explore a Pmk1-Mst12-Bip1 network required for appressorium-mediated infection by the blast fungus 🌾 www.biorxiv.org/content/10.6... Thread 👇

A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae

To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...

biorxiv.org

Diana Gómez De La Cruz@dianagdlc.bsky.social · 4mo ago

So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇 www.science.org/doi/10.1126/...

Molecular mimicry of a pathogen virulence target by a plant immune receptor

Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...

science.org

Jiorgos Kourelis@jiorgoskourelis.bsky.social · 4mo ago

📢 PDRA Position - Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Aug 2026 (flexible) 🧪 Wet lab + bioinformatics 📅 Up to 3 years (ERC-funded) 📍 South Kensington, on site ℹ️ shorturl.at/VIITk 🔗 kourelislab.com #PlantImmunity #PlantPathology 🙏 Share with interested candidates!

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

shorturl.at

KhongSam Chia@khongsamchia.bsky.social · 5mo ago

Preprint Alert 🚨 @philcarella.bsky.social lab stepping into TIR-ritory!! Project started by me but finished by talented PhD student @ebkennedy.bsky.social (Please follow her), with contribution from Zhao He and @jonathandgjones.bsky.social We investigated EDS1-dependency of TIR domain. See thread👇

Elenor Kennedy@ebkennedy.bsky.social · 5mo ago

@khongsamchia.bsky.social Extremely excited to share the first pre-print from my PhD project in the Carella lab, co-first authored with @khongsamchia.bsky.social 🎉 (Thread below ⬇️) www.biorxiv.org/content/10.6... Huge thanks to all co-authors and the #CarellaCapybaras for all the support 😊

Phil Carella@philcarella.bsky.social · 5mo ago

Check out our latest pre-print on the evolution of TIR activity/signalling: www.biorxiv.org/content/10.6...

biorxiv.org

Elenor Kennedy@ebkennedy.bsky.social · 5mo ago

@khongsamchia.bsky.social Extremely excited to share the first pre-print from my PhD project in the Carella lab, co-first authored with @khongsamchia.bsky.social 🎉 (Thread below ⬇️) www.biorxiv.org/content/10.6... Huge thanks to all co-authors and the #CarellaCapybaras for all the support 😊

The Sainsbury Laboratory@thesainsburylab.bsky.social · 5mo ago

New Preprint in collaboration with GoogleDeepMind: AI-guided discovery of atypical protein assemblies The @kamounlab.bsky.social discovered an 11-protomer complex thanks to the Structural Novelty Index , a new way to use AlphaFold to find protein assemblies that break the pattern.

AI-guided discovery of atypical protein assemblies

Artificial intelligence (AI) systems such as AlphaFold have transformed structural biology by enabling accurate prediction of protein structures. However, their capacity to uncover new classes of…

tsl.ac.uk

Daniel Lüdke@danielluedke.bsky.social · 5mo ago

Some predictions are high-confidence. These go to eleven! Huge congrats to the whole team ❤️ Such a privilege to work with you all.

AmirAli Toghani@amiralito.bsky.social · 5mo ago

Protein structure prediction changed biology. Protein assembly discovery is next. We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes. We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻 biorxiv.org/content/10.6...

AmirAli Toghani@amiralito.bsky.social · 5mo ago

UP TO ELEVEN - We expressed potato NRC7, imaged it by negative-stain EM, ran 2D classification. 🔬💥 Rings ~250 Å across — way bigger than canonical hexamers (~150 Å). 11 protomers. (5/n)

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Marc Somssich@somssich.bsky.social · 2y ago

Germany's ZB MED signs publishing partnership agreement with MDPI. At a time when MDPI is considered predatory to most, this is a baffling move. 🤑🤢 Doesn't reflect good on #BioMedicalResearch in Germany. www.mdpi.com/about/announ... #SciPub #ScientificPublishing #PredatoryPublishers #OpenAccess

Over 100 German Universities Partner with MDPI in New National Agreement

More than 100 German universities and research institutions have entered into a national agreement with MDPI. The publication agreement negotiated...

mdpi.com

Megan McDonald@mcdonaldmeganc.bsky.social · 2y ago

HI old friends! Finally took the leap here to say I have several open positions going in my lab at the moment (and more to come). 1) PhD studentship in collaboration with the Royal Horticultural Society (genomics) 2) Biochemistry Postdoc to understand how Starships move Check out the links below!

Jiorgos Kourelis@jiorgoskourelis.bsky.social · 2y ago

📢 PhD Opportunity in my lab on Plant Immune Receptor Bioengineering at @imperiallifesci.bsky.social 🌱 Start: October 2025 📅 Deadline: 12th January 2025 🇬🇧 Open to UK students 💰 Fully funded ℹ️ More info: tinyurl.com/w6ap9v9f ❗ #PlantImmunity #PlantPathology 🙏 Please share with interested candidates!

Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London on FindAPhD.com

PhD Project - Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London, listed on FindAPhD.com

findaphd.com

Ksenia Krasileva@kseniakrasileva.bsky.social · 2y ago

Several Jedis in our lab joined forces to review the rise of the plant immune resistance at DNA, RNA, and protein levels 💫🚀 check out the preprinted review here: zenodo.org/records/1420...

The Resistance Awakens: Natural diversity informs engineering of plant immune receptors at the DNA, RNA, and protein levels

Plants rely on germline-encoded, innate immune receptors to sense pathogens and initiate the defense response. The exponential increase in quality and quantity of genomes, RNA-seq datasets, and protei...

zenodo.org