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Clémence Marchal

@clemmar.bsky.social

Group leader at @ipbhalle.bsky.social Plant - Microbe Interactions 🌱🦠🍄 She/her

40 Posts579 Follower641 Folgt
Yo Akiyama@yoakiyama.bsky.social · 2w ago

Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!

Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer

Protein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...

cell.com

Adam Bentham@adamrbentham.bsky.social · 3w ago

Excited to see our new preprint on bioRxiv! 🌱🤖 We used AI protein design (RFdiffusion + ProteinMPNN) to build brand-new sensor domains from scratch and installed them in a rice NLR immune receptor engineering recognition of a Fusarium effector FoSSP17

@yuxuan-xi.bsky.social · 4w ago

Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...

@yuxuan-xi.bsky.social · 4w ago

Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...

Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors.

The rapid evolution of plant pathogens poses a persistent threat to global agricultural sustainability, often outpacing the discovery and deployment of natural disease resistance genes. While bioengin...

doi.org

Sophien Kamoun@kamounlab.bsky.social · 4w ago

We are excited to invite all current and former members of the Kamoun Lab, together with their lab members and our collaborators to the Kamoun Lab Alumni Meeting on Monday, 7 September 2026 ahead of the ECPP and BSPP at the Assembly House, Norwich.

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Sorek Lab@soreklab.bsky.social · 2mo ago

Preprint: Plant pathogens cleave 2’cADPR to suppress TIR immune signaling Inspired by knowledge on how phages inhibit bacterial immunity, we now show that disease-causing bacteria inhibit plant immunity in a similar way. A 🧵 www.biorxiv.org/content/10.6...

Plant pathogens cleave 2'cADPR to suppress TIR immune signaling

Small molecules produced by TIR (Toll-interleukin-1 receptor) domains are essential for plant immune signaling. A central TIR-derived signal is 2'cADPR, a cyclic ADP-ribose (ADPR) molecule that is gen...

biorxiv.org

The Plant Journal@theplantjournal.bsky.social · 2mo ago

📚 𝐅𝐨𝐜𝐮𝐬𝐞𝐝 𝐑𝐞𝐯𝐢𝐞𝐰 "How to frustrate a plant pathogen" 🐛 From structural genomics to AI-driven protein design, this review explores new strategies for engineering broad-spectrum resistance against plant pathogen effectors. ✍️ Knight, Heddle and @adamrbentham.bsky.social 👉 doi.org/10.1111/tpj....

How to frustrate a plant pathogen

Plant pathogens deploy large families of structurally related but sequence-diverse effector proteins to manipulate host cells, allowing them to evade immune recognition whilst maintaining the capacit...

doi.org

Margot Smit@likeyoda1.bsky.social · 2mo ago

Happy to share our new paper in @dev-journal.bsky.social . This project started while I was at Stanford with @stanfordstomata.bsky.social and was completed at @zmbp-tuebingen.bsky.social by @pablidopsis.bsky.social . Find it here: journals.biologists.com/dev/article/...

Targets of SPEECHLESS and FAMA control guard cell division and expansion in the late stomatal lineage

Highlighted Article: In Arabidopsis stomatal cells, SPEECHLESS persists into maturing guard cells where its balance with FAMA is essential for guard cell development. Transcriptomic and genetic analys...

journals.biologists.com

Will Shaw@willshaw.bsky.social · 2mo ago

New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @mokhalil.bsky.social + Gehring labs biorxiv.org/content/10.6... 🧵1/16

Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana

Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, u...

biorxiv.org

Daniel Croll@danielcroll.bsky.social · 2mo ago

🔔 Our synthesis on what’s going on in the field of TE control and RIP in the fungal world! Out now in Trends in Genetics!

Thomas Badet@tbadet.bsky.social · 2mo ago

Nearly a year after our symposium on Repeat-Induced Point (RIP) mutations, I’m happy to share the fruit of some of our discussions. The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti... We hope to spark interest in this underappreciated mechanism.

Evolution of major eukaryotic genome defense systems. The figure is organized along two axes representing core mechanistic features (homology recognition, small interfering RNA, and heterochromatin assembly) and their lineage-specific elaborations. We hypothesize that a recombination-independent DNA homology recognition system present in the eukaryotic common ancestor facilitated the emergence of both heterochromatin assembly and small RNA-based repeat silencing. From this conserved ancestral core, lineage-specific gene neofunctionalizations gave rise to distinct defense pathways: the RdDM pathway in plants; the piRNA and KRAB–ZFP pathways in vertebrates; and the repeat-induced point mutation (RIP), methylation induced premeiotically (MIP), MSUD, and tandem repeat-induced sexual silencing (TRISS) systems in filamentous ascomycete fungi. Question marks indicate steps for which the molecular mechanisms remain unknown.
Christine Mayr@christinemayr.bsky.social · 2mo ago

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

@parkergroup.bsky.social · 2mo ago

TIRs are key regulators of plant immunity, but the role of conserved TIR-only proteins has remained unclear. Here, we compare TIR-only proteins from Arabidopsis and barley and show that they share a conserved role in plant immunity. www.biorxiv.org/content/10.6...

Conserved TIR-only proteins drive transcriptional defense and basal immunity in dicot and monocot plants

Toll/interleukin-1/resistance (TIR) domain NADase enzymes signal in plant immunity by producing ribosylated nucleotide second messengers which activate EDS1 dimer-helper NLR pathways to restrict patho...

biorxiv.org