Miguel Godinho Ferreira
@miguelgf.bsky.social
Research scientist interested in #cancer and #aging. Studies the ends of #chromosomes - #telomeres 🧬 - and what happens when they get fu€&ed up💥... and all this using #zebrafish! 🐟🐟🐟 https://orcid.org/0000-0002-8363-7183
Check out our meeting report! www.nature.com/articles/s43...
Questions of the future in aging and longevity research at the GIMM Festival - Nature Aging
On 4–6 September 2025, the Gulbenkian Institute for Molecular Medicine (GIMM) hosted its inaugural GIMM Festival in Lisbon, Portugal. The three-day meeting on ‘Aging and Longevity’ brought together re...
nature.com
The "brave new world" of biomedical research: organs-on-chips, organoids and computational models. 🔬 🧪 🐁 🐟 A must read... 👇 www.nature.com/articles/d41...
The age of animal experiments is waning. Where will science go next?
Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome.
nature.com
The Greenland shark, the longest-lived vertebrate, does not avoid heart aging. Instead, it resists heart disease and maintains organ function into extreme old age. Preserving a "youthful state" is not the only path to longevity. Preprint by Cellerino lab👇 www.biorxiv.org/content/10.6...
biorxiv.org
I am excited to begin a #Sabbatical at @ki.se (Genander Lab). We are expanding our #zebrafish findings (PMID: 37142828, 40490553) to human #organoids to study #cGAS-#STING #inflammation and #telomerase rescue in the #GI tract. 🧬🩺 Special thanks to @EMBO.org @cnrs.fr for the support. #Aging #TBDs
Me answering 5 questions on #science and #aging during my recent visit to the @leibnizfli.bsky.social Institute in Jena, Germany. ☺️ youtu.be/nJZu0Su0lbs?...
Interview with Dr. Miguel Godinho Ferreira
YouTube video by Leibniz-Institut für Alternsforschung - FLI e.V.
youtu.be
Happy and proud with our lab’s presentations at Second @frenchzebrafish.bsky.social meeting in Toulouse! Go Fish 🇫🇷🐟!
📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please. Focus: intestine aging & immunity in fish 🐟 Start Nov–Dec 2025 • ~€3,175/mo Apply: ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks GUTPOWER (reef fish) → tinyurl.com/mt2ekpks
📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please. Focus: intestine aging & immunity in fish 🐟 Start Nov–Dec 2025 • ~€3,175/mo Apply: ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks GUTPOWER (reef fish) → tinyurl.com/mt2ekpks
Interested in cGAS-STING? Come and join us on 21st of October 2025 (9:30-12:30) in Nice, France! univ-cotedazur.fr/recherche-in...
Nucleic acid sensing and innate immunity - Academy 4 Seminar Series #19 - Le Galet CHU PASTEUR NICE - October 21st, 2025 - Université Côte d'Azur
univ-cotedazur.fr
Aging: “So far, no one has managed to rejuvenate anyone.” What are #telomeres? How can #zebrafish help in the study of #aging? Miguel Godinho Ferreira, a Portuguese scientist working in France, answers. Let's talk about longevity and aging. (Portuguese only) www.publico.pt/2025/09/16/c...
Envelhecimento: “Até agora, ninguém conseguiu rejuvenescer ninguém”
O que são os telómeros? Como pode o peixe-zebra ajudar no estudo do envelhecimento? Miguel Godinho Ferreira, cientista português a trabalhar em França, responde. Falemos então sobre a longevidade.
publico.pt
Great opportunity to meet with French zebrafish community! Our lab will gladly join! Go fish! 🐟
Anabela Bensimon-Brito@bensimonbrito.bsky.social · 11mo ago🚨 Don’t miss it! Abstract submission closes Monday, Sept 15. frenchzebrafishmeeting.fr Fantastic keynote speaker @KarinaYaniv and a great opportunity to connect with the @FrenchZebrafish Community. All talks will be in English. Join us! #FZM #zebrafish
It is so nice to have this trail on our recent work. Thank you, @cyrilpedia.bsky.social! The follow up is just around the corner! 🙂
Thiago Carvalho@cyrilpedia.bsky.social · 11mo ago'Telomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in #zebrafish.' www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal
imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...
embopress.org
Comment in issue 17: Making sense of oxygen sensing Glutamine sensing by mTORC1 via GCN2 Androgen signaling control via Parp7 and an ADP-ribosyl degron Dendrite-like pseudopods let macrophages ingest bacteria Cover by @miguelgf.bsky.social et al www.embopress.org/toc/14602075...
Our paper was offered the cover of The EMBO Journal. 😀 We discovered that activation of cGAS-STING causes aging in response to very short telomeres. Zebrafish deficient in telomerase and sting, reverse premature death, reduced fertility, frailty and cancer. 👉 tinyurl.com/nhd4bfb9
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal
imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...
embopress.org
Not all species age the same way 😉 “We conclude that M. musculus maintains long telomeres in blood and tail throughout life” Congrats Rhian and Dudy et al! 👏 House mouse maintains constant telomere length throughout life url: academic.oup.com/nar/article/...
The house mouse maintains constant telomere length throughout life
Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length
academic.oup.com
What’s on at #GIMMFest Day 1 & 2? We’ll kick things off with big ideas to spark your curiosity, then dive into fresh perspectives on the future of aging and the everyday experiences that shape it. 🔗 gimm.pt/pt-pt/gimm-festival/#program
Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation. Go Fish! 🐟🐟🐟 www.thno.org/v15p7308.htm
Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration
thno.org
Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish #preLight prepared by Jawdat Sandakly⬇️ 👀 prelights.biologists.com/highlights/t...
Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights
Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish
prelights.biologists.com
Thanks for the highlight, @zebrafishrock.bsky.social! This is the first last author manuscript of Bruno Lopes-Bastos. We are very happy for this!
Zebrafish Rock!@zebrafishrock.bsky.social · last yr.Highlights work from @miguelgf.bsky.social et al. 🐟
Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts. Secure your spot on: gimm.pt/gimm-festival/ @nataging.nature.com
Here’s the EMBO Journal highlight on our paper!
The EMBO Journal@embojournal.org · last yr.How do shortened telomeres affect organismal health-/lifespan? Using a zebrafish model, Miguel Godinho Ferreira @miguelgf.bsky.social and coworkers show that premature aging symptoms depend on cGAS-STING signaling www.embopress.org/doi/full/10....
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal www.embopress.org/doi/full/10....
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal
imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...
embopress.org
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish www.embopress.org/doi/full/10....
cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal
imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...
embopress.org
It was a pleasure to invite our neighbour Corine BERTOLOTTO to IRCAN. It was a great review of the lab's work and a very nice return to Hopital Pasteur, Nice. "Uveal melanomas: identification of new prognosis biomarkers and therapeutic targets"
“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ
TODAY - You are still on time for early bird registration for the GIMM Festival on #Aging and #Longevity! Lisbon from 4–6 September 2025.
GIMM Fest | Aging and Longevity: Registrations open now! September 4-6 2025, Portugal, Lisbon. The brand new Gulbenkian Institute, launching – the very first GIMM Festival – "Aging and Longevity" to explore the future of aging through science. gimm.pt/gimm-festival/
