www.nature.com/articles/s41... 📢 Check out our article in its final format in @natcomms.nature.com Unbiased recording of thymic cellular interactomes via synthetic Notch receptors #synNotch #Tcells #thymus #syntheticbiology @qmbci.bsky.social

Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors - Nature Communications

Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...

nature.com

Explore the March #ExpHem Issue now with articles from Atsushi Iwama, Jian Xu, Momoko Yoshimoto, @ganuzalab.bsky.social and many more ➡️ www.exphem.org/issue/S0301-...

journals.lww.com/co-hematolog... Check our Review article on the emerging roles of BEACH Domain Containing Proteins in hematopoiesis and immune homeostasis published in Current Opinion in Hematology

onlinelibrary.wiley.com/doi/10.1111/... Thrilled to share our work in BJH highlighting the therapeutic potential of targeting the WNT pathway to block the crosstalk among stromal and leukemic ALL cells to prevent chemoresistance. Collab. w/ Bela Wrench @foteinikal.bsky.social @qmbci.bsky.social

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

Chemotherapy-induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross-talk and restores therapeut....

onlinelibrary.wiley.com

www.nature.com/articles/s41... Extremely proud of our publication in @natcomms.nature.com. We report a genetic system based on synthetic Notch receptors (Yin&Yang) that we engineered to record and identify cell-to-cell interactions in vivo in the thymus. Collaboration @mirjana-efremova.bsky.social

Explore the February #ExpHem issue, with articles from the labs of Jean-Pierre Lévesque, @ganuzalab.bsky.social, Katrin Ottersbach, Duonan Yu and more! Read the latest research in experimental hematology now on www.exphem.org.

Have you ever wondered about Pig HSCs? Today is your lucky day! Check out this excellent work from @ganuzalab.bsky.social. Well done! Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar. www.exphem.org/article/S030... @isehsociety.bsky.social

Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow (BM) transplants [1,2]. Yet, ...

exphem.org

Merry Xmas to you and your family from our lab. 🎅🎄🎉🎄🎅☃️☃️🎉

Check out our collaborative Review Article with Dr Momoko Yoshimoto on: HSC-independent and -dependent hematopoiesis: new insights and lineage tracing methods. - Experimental Hematology www.exphem.org/article/S030... @isehsociety.bsky.social @qmbci.bsky.social

HSC-independent and -dependent hematopoiesis: new insights and lineage tracing methods.

Hematopoietic cells are mesodermal in origin and emerge through a highly regulated process known as endothelial-to-hematopoietic transition (EHT), which yields various hematopoietic progenitors 1,2 In...

exphem.org

Check our new article: Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar We must understand pig hematopoiesis to enable bone marrow xenotransplantation. @qmbci.bsky.social Emma Bailey @foteinikal.bsky.social www.exphem.org/article/S030...

Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow transplants1,2. Yet, thousand...

exphem.org

ASH is committing more than $12 million to address research funding challenges and support the next generation of hematologists. Learn more: ow.ly/sK3050W735W

Thanks @isehsociety.bsky.social for featuring our lab. #SimplyBlood. Thanks @billgrey.bsky.social for the interview.

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

This week on #SimplyBlood 🩸 we're highlighting the @ganuzalab.bsky.social lab out of the Centre for Haemato-Oncology Barts Cancer Institute, Queen Mary University of London, UK. Read more on www.simplyblood.org

Yay @ganuzalab.bsky.social! So proud of my former trainee and his wonderful lab.

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

This week on #SimplyBlood 🩸 we're highlighting the @ganuzalab.bsky.social lab out of the Centre for Haemato-Oncology Barts Cancer Institute, Queen Mary University of London, UK. Read more on www.simplyblood.org

This week on #SimplyBlood 🩸 we're highlighting the @ganuzalab.bsky.social lab out of the Centre for Haemato-Oncology Barts Cancer Institute, Queen Mary University of London, UK. Read more on www.simplyblood.org

Pubmed down! Expected under the current craziness.

🔥 New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data. Performed with the support of Cris Cancer and @erc.europa.eu

Raúl Sánchez-Lanzas and Foteini Kalampalika @foteinikal.bsky.social presenting their work on clonal hematopoiesis and aplastic anaemia at the Haematological Tumour Microenvironment Meeting ESH in London!!! Well done guys 😊!!

Use this form to tell us how the new US administration is affecting your research, or suggest future coverage https://go.nature.com/42SyoUu

Are the Trump team’s actions affecting your research? How to contact Nature

Use this form to share information with Nature’s news team, or to make suggestions for future coverage.

go.nature.com

Obituary: Federico Mayor Zaragoza (1934-2024) former UNESCO chief who championed neonatal screening https://go.nature.com/3WXw9LQ

Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening

The biochemist introduced the first heel-prick tests for newborn babies in Spain, protecting infants from life-changing metabolic conditions.

go.nature.com

Excited to share our work - online today as a preprint. Here, we characterize precocious aging in HSCs of mice and people with sickle cell disease. Excitingly, we demonstrate the potential of senolytics to restore HSC function to the bone marrow of mice with SCD. www.biorxiv.org/content/10.1...

Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease

Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) ...

biorxiv.org

@ganuzalab.bsky.social Exciting new work from my former trainee, Mikel Ganuza, now running his own excellent team. Congrats! #HSCs #clonalhematopoiesis #science www.nature.com/articles/s41...

A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones - Leukemia

Leukemia - A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones

nature.com