Excellent review in #ExpHem on senescence in HSCs from the @smckinneyfreeman.bsky.social lab at @stjuderesearch.bsky.social. Being able to distinguish cell state at the molecular level is needed to identify these cells and prevent them from contributing to disease. www.exphem.org/article/S030...

Hematopoietic stem cell senescence and opportunities for intervention

Cellular senescence is a fundamental stress response program involved in embryonic development, wound healing, immunity, disease pathologies, and aging, which alongside apoptosis, serves as a protecti...

exphem.org

Our paper on the potential of senescence-targeting therapies to restore function to the bone marrow in sickle cell disease is finally out! Congrats to all the amazing people who worked on this story! @stjuderesearch.bsky.social www.science.org/eprint/CUFEJ...

Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans

Sickle cell disease–induced hematopoietic stem cell senescence and loss of function are reversed in SCD mice by treatments targeting senescence.

science.org

Following some amazing discussions with colleagues at EHA about our recent publication in @natcellbio.nature.com, here are some important points showing why considering HSC reconstitution kinetics will make you re-think the concept of lineage biases rdcu.be/fkASJ 1/9

RIP Brandon Clarke. So sad.

Peter@peterman37.bsky.social · 6mo ago

Damn. Brandon Clarke. RIP. www.youtube.com/watch?v=jvj-...

'The US National Institutes of Health (NIH) has so far not received approval to spend any of the research funding allocated in a budget bill signed into law on 3 February.' www.nature.com/articles/d41...

White House stalls release of approved US science budgets

The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

nature.com

Thanks to the Nature team for digging into this. Apportionment is one of those inside-baseball issues that I hoped never to need to learn about... But here was are.

Max Kozlov@maxkozlov.bsky.social · 8mo ago

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

Insightful seminar by Roderic Guigó: Figure 1 of the Craig Venter human genome paper (Science, 2001) was made by a Spanish PhD student who had no salary and earned his living serving tables in a Pizzeria.

Centre de Regulació Genòmica (CRG)@crg.eu · 9mo ago

Exactly 25 years ago, @rodericguigo.bsky.social and his PhD student published the first draft of the human genome in Science. The Catalan researchers were the only two from all Spain that took part. Here they are reflecting on the huge scientific feat: www.crg.eu/en/news/25-y...

INTERESTED IN SINGLE-CELL LINEAGE TRACING? Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab 🎉🎉 nature.com/articles/s41... With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis. Read link: rdcu.be/e50gy

Charting single-cell lineages with synthetic and natural barcodes - Nature Reviews Genetics

In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...

nature.com

I have a picture of her in my lecture to the Dev Bio students about embryonic stem cells. A pioneer in the field. Thank you for your work. RIP.

Denis Duboule@denisduboule.bsky.social · 9mo ago

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells. A great colleague, a friend and a lovely person.

Please can you all stop calling him Steve. This phase will probably only last a day or two. Thanks.

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

science.org

Jamie Raskin not only graduated from Harvard with his JD, (editor of the Harvard Law Review)...he is so dedicated to our country and our constitution that this man BURIED HIS SON, came into work the next day to experience an insurrection, and started writing articles of impeachment THAT DAY. 1/

Bill Grueskin@bgrueskin.bsky.social · 9mo ago

“You’re not even a lawyer,” Pam Bondi yells at Jamie Raskin, who graduated from Harvard Law School, has written several books about the legal system, and has taught constitutional law for more than 25 years. www.theguardian.com/us-news/2026...

Roses are red, platelets are too, Hematology keeps thriving with every breakthrough. 🩸💌 This Valentine’s Day, show some love by supporting hematology research through the ASH Foundation: ow.ly/9v8r50YcZaK #ValentinesDay #Hematology #Donate #Fight4Hematology

In honor of Blood's 80th anniversary, we're looking back at all of the journal's past Editors in Chief. Today we're kicking off with our Founding Editor, Dr. William Dameshek (served 1946-1969). Learn more about him in this special feature: linkedin.com/feed/update/...

#history #scientifichistory #bloodjournal #hematology #editorinchief #eic #founder | Blood Journals Portfolio

In honor of Blood’s 80th anniversary, we’re looking back at all the past Editors-in-Chief, starting with our Founding Editor! Dr. William Dameshek (1900–1969) was a pioneering American hematologist ...

linkedin.com

You don't really want to know, but... 2021: 412 awards 2022: 430 awards 2023: 442 awards 2024: 497 awards 2025: 252 awards 2026 (to date): 0 awards

Brian Marron@brianmarron.bsky.social · 9mo ago

Do you happen to have AHRQ numbers?

BREAKING NEWS: Steve has had a shower. He's got a busy week ahead (his words, not mine).

Noooooo!!!! Not JJJ!!!!!!

The Daily Memphian@dailymemphian.bsky.social · 9mo ago

The Memphis Grizzlies traded Jaren Jackson Jr. and three other players to the Utah Jazz.

When you agree to serve in a committee

Judge Biery is a badass and my hero

“I just checked—it turns out that Art. II, Sec. 1 of the Constitution of the United States does *not* say ‘The executive Power shall be vested in a bunch of sociopaths who think they can do whatever the f*ck they want and make sh*t up as they go along.’” — George Conway

If this nation has a conscience, what will it take to shake it from its slumber?

Aaron Stewart-Ahn@badideas.bsky.social · 9mo ago

A video of Alex Pretti reading out the final salute of an unnamed veteran he cared for until the end of his life in the ICU, posted to Facebook by his son.

An unexpected topic I encountered during my PhD: tricellular junctions. I first knew them as local regulators of tissue mechanics, but over time have realised their broader impact at the tissue scale. I wrote a brief overview of this in a thread for @epimechfc.bsky.social.

epithelial mechanics fan club@epimechfc.bsky.social · 10mo ago

How can structures at the vertex of 3 cells have effects at the tissue level? Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...

Here is a picture of a baby otter for no good reason.

Lots of problems with multi year funding mechanism. Far fewer grants can be funded and they can only be funded for 4, not 5 years even though most grants funded by the normal mechanism are 5 years. It’s a back door way for Russell Vought to choke off science funding

Jenna Norton@jenna-m-norton.bsky.social · 10mo ago

At least prior to 2025, you could expect all years on your grant (barring major issues). The main problem with MYF is the rapid transition absent an NIH budget increase. We can pay 4 grants for 1 year, or only 1 grant for 4 years. Under MYF, we can pay far fewer grants (1 instead of 4).

Have you ever wondered about Pig HSCs? Today is your lucky day! Check out this excellent work from @ganuzalab.bsky.social. Well done! Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar. www.exphem.org/article/S030... @isehsociety.bsky.social

Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow (BM) transplants [1,2]. Yet, ...

exphem.org

The struggle is real! Studying HSCs during inflammatory is a challenge as their phenotype changes. Check out this excellent new work in Experimental Hematology reporting another useful tool for identifying HSCs under these conditions. www.exphem.org/article/S030... @isehsociety.bsky.social

Endothelial protein C receptor CD201 is a better marker than stem cell antigen-1 to identify mouse long-term reconstituting hematopoietic stem cells following septic challenge

Stem cell antigen 1 (SCA1) has been used for decades to separate mouse hematopoietic stem and progenitor cell subsets; however, it fails to do so when mice are challenged by pathogens, interferons, or...

exphem.org

It’s so special to be nominated for this by my trainees. Their hard work makes my job easy and I am so grateful to work with them every day. Mentorship is hard and I benefit from the awesome example of my own fantastic mentors. Thank you Colleen, Peggy @goodell-lab.bsky.social and George!

St. Jude Children's Research Hospital@stjuderesearch.bsky.social · 10mo ago

St. Jude congratulates Shannon McKinney-Freeman, PhD, on being named the 2025 Postdoctoral Association Mentor of the Year. Nominated by four mentees, McKinney-Freeman is recognized for her dedication to advancing the next generation of scientists. #MentoringMonth

Gratitutde to all NIH study section participants who are participating in rescheduled meetings now and in January. Thank you for your service and thanks also to the hard working NIH staff who are making these happen. 🥰🧪

For decades, the mystery of how DICER1 mutations promote pediatric rhabdomyosarcoma remained unsolved. Mark Hatley, MD, PhD, and his lab cracked the case, powered by advancements in single-cell RNA sequencing, revealing new paths for intervention. https://ow.ly/UiCG50XU294

NIH grant applicants: October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD. grants.nih.gov/grants/guide...