Thanks to Diane Krause and the editors for the opportunity, and to the other authors @alejofraticelli.bsky.social @shalinhnaik.bsky.social in the clonal tracking series: doi.org/10.1182/bloo... We also recorded a podcast together—well worth a listen! bloodpodcast.transistor.fm/episodes/rev...

Introduction to a review series on clonal tracking in hematopoiesis

Over the past decade, advances in single-cell genomics, lineage tracing, and computational phylogenetics have transformed our understanding of hematopoiesi

doi.org

Erez, Omri, Pasha, Roshina, and Ofir Cohen find HSCs lack transplant potency during Salmonella infection. HSCs recover! Molecular data point to proliferation. We have a great opportunity to realize the exhaustion/regeneration of our own adult stem cells now. www.sciencedirect.com/science/arti...

4-year expired scATACseq kit…. Worked like a charm.

Complementing our recent #Review 'Charting single-cell lineages with synthetic and natural barcodes' by @alejofraticelli.bsky.social & Victoria Parreno (rdcu.be/e50gy), Kun Wang, Xionglei He & Zheng Hu review 'Computational approaches for multimodal lineage tracing': go.nature.com/4nDGGbk

Computational approaches for multimodal lineage tracing - Nature Reviews Genetics

Multimodal lineage tracing links heritable ancestry with single-cell molecular states to reveal how cell fates emerge during development, regeneration and disease. In this Review, the authors survey k...

go.nature.com

Upcoming cancer epigenetics conference in Paris (Oct 13-16, 2026). Consider registering: www.atoutcom.com/cancer-epige...

Clone2vec finally published!!! Sweet new tech! I highly recommend it! Congrats Sergey et al!

bioRxivpreprint@biorxivpreprint.bsky.social · 3mo ago

Clonal embeddings allow exploratory analysis of lineage-resolved single-cell data https://www.biorxiv.org/content/10.64898/2026.04.30.720820v1

Abstract submissions close 17 April. Don’t miss your chance to present at #ISEH2026! Share your science with the global ISEH community. 🔗 iseh.org/Annual-Meeti...

First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @isehsociety.bsky.social www.exphem.org/article/S030...

Association of Infection Frequency and Incident Clonal Hematopoiesis of Indeterminant Potential

Clonal hematopoiesis of Indeterminant Potential (CHIP) is an age-related phenomenon characterized by clonal expansion of hematopoietic stem cells (HSCs)1. CHIP results from a fitness advantage conferr...

exphem.org

We’re recruiting new Research Group Leaders. We offer: 🔬 World-class IT infrastructure 🧠 Creative freedom for your research 📊 Access to the world’s most comprehensive open biological data Apply by 11 April embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ResearchCareers @johnlees.bacpop.org @embl.org

Apply now! The 2026 call for the EMBO Young Investigator Programme is now open with a deadline of 1 April 12:00 midday CEST. 🧪 More info here: https://www.embo.org/funding/fellowships-grants-and-career-support/young-investigator-programme/ #LifeSciences #research #funding

The EMBO Young Investigator Network consists of young investigators, installation grantees and global investigators. 🧪 Find more information on the individual programmes here: https://www.embo.org/the-embo-communities/embo-young-investigator-network/ #LifeSciences #research #funding

New work by @sagnera.bsky.social & co A conserved sequence of TFs: OC2 → Pou2f2 → Pou3f1 drives chronological diversification of spinal neuron subtypes across multiple cardinal domains Spinal neuron diversity is generated by integrating spatial & temporal programs www.science.org/doi/10.1126/...

Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors

Molecular and functional diversification of spinal cord output neurons by a conserved sequence of transcription factors.

science.org

Come see all three receive their awards and talk about their science @isehsociety.bsky.social annual meeting in Frankfurt: iseh.org/Annual-Meeting Come for the science and join our community.

Eirini Papapetrou@eirinipapapetrou.bsky.social · 5mo ago

Incredibly honored to receive the 2026 McCulloch & Till award by @isehsociety.bsky.social. Congratulations to Ellen Rothenberg and @bethpsaila.bsky.social - proud to be in such great company!

Just out! 👀 for TFs that regulate TEs.Clara's work with @tamas-schauer.bsky.social @marliesoomen.bsky.social @palmrinmoy.bsky.social and bluesky-less lab members 🌎 identifies TBP as a regulator of specific ERVL class: MaLRs in 🐭embryos -as always -feedback welcome👍 link.springer.com/article/10.1...

Have you ever wondered about Pig HSCs? Today is your lucky day! Check out this excellent work from @ganuzalab.bsky.social. Well done! Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar. www.exphem.org/article/S030... @isehsociety.bsky.social

Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow (BM) transplants [1,2]. Yet, ...

exphem.org

www.nature.com/articles/s41... Extremely proud of our publication in @natcomms.nature.com. We report a genetic system based on synthetic Notch receptors (Yin&Yang) that we engineered to record and identify cell-to-cell interactions in vivo in the thymus. Collaboration @mirjana-efremova.bsky.social

new out in Nature www.nature.com/articles/s41...

Ageing promotes metastasis via activation of the integrated stress response - Nature

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

nature.com

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you! 1/n

Proud of @juruehle.bsky.social for getting her PhD paper on biorxiv! In it, we take synthetic enhancer screens to the single cell level, offering new insight into how transcription factors and enhancers interact 👀

Julia Rühle@juruehle.bsky.social · 5mo ago

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩... 🔗 doi.org/10.64898/202...

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology Join our community & shape the future of research journals.biologists.com/dev/article/...

Preprint Editors – Development's next step into the preprint landscape

Summary: This Editorial announces a call for Preprint Editors in Development to help expand the journal's relationship with preprints by curating our ‘In preprints’ articles.

journals.biologists.com

I still remember to this day how much this specific day, the day the genome draft was published, pushed me into choosing to study life sciences… it was a breakthrough moment for so many young kids. 25 years, wow.

Lars Velten@larsplus.bsky.social · 5mo ago

Insightful seminar by Roderic Guigó: Figure 1 of the Craig Venter human genome paper (Science, 2001) was made by a Spanish PhD student who had no salary and earned his living serving tables in a Pizzeria.

INTERESTED IN SINGLE-CELL LINEAGE TRACING? Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab 🎉🎉 nature.com/articles/s41... With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis. Read link: rdcu.be/e50gy

Charting single-cell lineages with synthetic and natural barcodes - Nature Reviews Genetics

In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...

nature.com

📢 The 5th edition of #ISCO – Innovation in #SingleCell #Omics is almost here! 🗓 28–29 May 2026 📍 @prbb.org  🚨 Early-bird deadline: 28 Feb Register: https://www.isco-conference.eu/ @crg.eu @carrerasijc.bsky.social @alejofraticelli.bsky.social

Leukemia stem cell expansion cultures reveal clonal drivers of leukemogenesis and therapy response https://www.biorxiv.org/content/10.64898/2026.02.24.707683v1

🚨 NEW @FraticelliLab PREPRINT JUST WENT LIVE biorxiv.org/content/10.6... Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!

Holy macaroni!!!

bioRxiv Genomics@biorxiv-genomic.bsky.social · 5mo ago

In vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster https://www.biorxiv.org/content/10.64898/2026.02.23.707349v1

Delighted to have Kim tell us all about their recent publication on fetal-adult transition of intestinal stem cells! www.cell.com/cell-stem-ce...

Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition

Using engineered scaffolds mimicking intestinal crypts, Maimets et al. show that tissue geometry drives epithelial maturation by regulating YAP activity. Crypt-like structures promote differentiation ...

cell.com

IRB Barcelona@irbbarcelona.org · 5mo ago

📢 This Week at #IRBBarcelona: Join us for a plenary #seminar this Friday, with Dr. @kimbakjensen.bsky.social, from the @novo-nordisk.bsky.social Center for Stem Cell Medicine. 🤝 Hosted by @batllelab.bsky.social & @alejofraticelli.bsky.social Register here ➡️ https://shorturl.at/fURzD

Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! 😎 (please share) careersearch.stanford.edu/jobs/life-sc...

Life Science Research Professional 1 in School of Medicine, Stanford, California, United States

The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....

careersearch.stanford.edu

🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...

Head, Advanced Genomics Technologies Core Facility (Ref. CF/26/01) - IRB Barcelona

IRB Barcelona invites applications for the position of Head, Advanced Genomics Technologies Core Facility. The successful candidate will report to the Director, Technology Strateg...

recruitment.irbbarcelona.org

Excited to announce that our #PUFFFIN plasmids are finally available on @addgene.bsky.social to make PUFFFIN neighbour labelling even more accessible. You can find the plasmids here www.addgene.org/Sally_Lowell/ and our paper here link.springer.com/article/10.1... Big thanks @cellysally.bsky.social!