Frank Nijpels from VitriMatics paid us a visit today. Not only did he repair our broken VitroBot Mark IV and returned it in person, he also brought some extremely cool tools ❄️ for reliable cryo-EM grid freezing 🔬. Check out the VitriClip and the SupraBlot at vitrimatics.com. #cryoEM #cryoET

New preprint! 👀RNAse activity has to be tightly regulated.✂️🧬Here, we present the dynamic architecture of the conserved Rixosome complex – a major player in ribosome maturation and heterochromatin maintenance. Our results give insights into its mode of activation.👇 #cryoEM #Ribosome #RNA

Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism! Work led by graduate student @paulafprado.bsky.social in our group. www.biorxiv.org/content/10.6... 🧵 1/9

📰Happy to share our preprint.🥳Here we investigate🔬, the essential role of the conserved RNA helicase Drs1. We show that its engagement and activity license timely incorporation of 25S rRNA domain III into maturing nucleolar pre-60S subunits.👇 doi.org/10.64898/2026.09.05.749353 #cryoEM #ribosome #RNA

🧵 We’re excited to share our new bioRxiv preprint on how INO80 reads promoter-proximal DNA sequence features to position +1 nucleosomes 🧬 Amazing work by Mariia, Annika, and others! 🤩 🔗 www.biorxiv.org/content/10.6... #ChromatinBiology #StructuralBiology #Nucleosome #INO80

Preprint alert: a helicase watching the ribosomal A-site 👀🧬 Our cryo-EM structure reveals how yeast Dhx29 senses mRNA hairpins forming in the A-site and positions its helicase at the mRNA entry channel to resolve them during translation elongation: doi.org/10.64898/202... #cryoEM #ribosome #RNA

It's finally out now in @natcomms.nature.com! We used cryo-EM + simulations to watch the Na⁺/H⁺ antiporter NhaA in action across a wide range of pH—and uncover how pH, Na⁺ binding, and structural changes are coupled. Read here 🔗 www.nature.com/articles/s41...

We are sharing a tool developed initially for internal use called VOSE (Volume Operations Simplified Edition) today. It is written specifically to work in ChimeraX (version 1.5+), with no additional libraries necessary to be installed. github.com/jparmachelab...

GitHub - jparmachelab/ChimeraX-VOSE: ChimeraX Volume Operations Simplified Edition

ChimeraX Volume Operations Simplified Edition . Contribute to jparmachelab/ChimeraX-VOSE development by creating an account on GitHub.

github.com

Proud to share our latest preprint! 🥳 Using a multidisciplinary approach, we uncover a dual function of the snR37 H/ACA snoRNP - combining pseudouridylation with ribosome chaperone activity within a single RNP.🔬🧬 Challenging the traditional view of snoRNP function. 👇 #cryoEM #ribosome #RNA #snoRNA

Glad to be part of this great work from @beckmannlab.bsky.social, led by @guan316.bsky.social and @timodenk.bsky.social, exploring the mechanics of co-translational acetylation of histones by NAA40.

Dandan GUAN@guan316.bsky.social · 7mo ago

Attention handsome people and brilliant minds ！👀🤩 😜🥳Our new paper out in Nature Communications! @natcomms.nature.com @beckmannlab.bsky.social @timodenk.bsky.social @kirmizislab.bsky.social @arielchk.bsky.social #cryoEM#ribosome#translation#histones 🤩Link: www.nature.com/articles/s41...

How are histones acetylated as they emerge from the ribosome? We show that NAA40 cooperates with the NAC complex to enable co-translational acetylation of H2A/H4, revealing NAC as a coordinator of nascent protein modification. Read more about our collaboration with @kirmizislab.bsky.social #cryoEM

NAA40 and NAC cooperate in co-translational histone acetylation in humans

Nature Communications - N-terminal histone acetylation by human NAA40 alters epigenetic signaling and affects gene regulation. Here, the authors combine biochemistry and cryo-EM to unravel the...

rdcu.be

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

ZAK activation at the collided ribosome - Nature

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

nature.com

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI

🎉Thrilled to share that our lab has been awarded an ERC Synergy Grant @erc.europa.eu! Excited for amazing collaborations with the Pertschy (Uni Graz), Henras (CBI Toulouse), and Woodson (Johns Hopkins) labs. #ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins

We are excited to share our collab with @kedrov-lab.bsky.social! Using Cryo-EM❄️ on an amazing sample, we found that YidC is recruited to the back of SecYEG during late-stage substrate insertion —supporting that the "back-of-Sec" route observed in eukaryotes also exists in bacteria 🦠. Check it out👇👇👇

Kedrov Lab @ HHU@kedrov-lab.bsky.social · last yr.

Very special feelings to announce this one... A project that started like 10 years ago is reaching the finish line, ready to shine. In a dream-team with @beckmannlab.bsky.social we solved the long-chased structure of the active membrane protein insertase SecYEG-YidC www.biorxiv.org/content/10.1...

How does an unusual heptameric AAA-ATPase translocate fully-folded Rieske protein across the inner mitochondrial membrane? Cryo-EM & functional data by Roland Beckmann and coworkers show how Bcs1 alternates between different states during its translocation activity. www.embopress.org/doi/full/10....

We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇