Out now in #NAR! 🧬 I mapped the evolution of the ribosomal exit tunnel through the "eyes" of the nascent chain using MD simulations. How do the tunnel geometry, lateral branching, and chemical landscape change across 64 distinct ribosomes from the 3 domains of life? academic.oup.com/nar/article/...

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain

Abstract. The exit tunnel is a universally conserved feature of the ribosome that directs the nascent polypeptide into the cellular environment and is invo

academic.oup.com

We are looking for someone to lead the new Facility for Protein Biochemistry & Biophysics at the MPI of Immunobiology and Epigenetics in Freiburg — please spread the word and apply if you are interested!

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · last mo.

🚀 Job alert: We’re starting a new Facility – and you can lead it! The MPI-IE & @mariekeoudelaar.bsky.social are hiring a Head of Protein Biochemistry & Biophysics to launch and lead a brand-new Core Facility in Freiburg 🇩🇪. Once-in-lifetime-chance. Details ⬇️ jobs.ie-freiburg.mpg.de/jobposting/b...

We often talk about complex protein folds but what does that really mean? Turns out we don't have a good metric for it. So we made a game to make one! Head over to our website to vote on which fold you think is more complex and why! pacesalab.com/foldcomplexi...

Our new contribution about #ribosomes. While preparing computer simulations for another project, we noticed that many r-protein parts were missing from the #cryoEM model. Surprisingly, we found this to be a general feature: a coat of #IDPs on the ribosome's surface. www.biorxiv.org/content/10.6...

Ribosomes are covered by a coat of flexible protein fragments

Ribosomal proteins contain flexible terminal regions that are averaged out during electron density reconstructions, rendering them absent from experimental models derived by X-ray crystallography or c...

biorxiv.org

📢 (1/2) Excited to share the first preprint from my PostDoc! We developed UbSeRP to map co-translational ubiquitination in a translatome-wide, revealing thousands of quality control sites, and how they reshape with aging. www.biorxiv.org/content/10.6... #proteostasis #ribosomes #preprint

Ubiquitin selective ribosome profiling reveals systematic principles of co-translational quality control

Protein biogenesis is a stress- and error-sensitive process that can lead to nascent protein misfolding and aggregation, challenging cellular proteostasis. Co-translational ubiquitination (CTU) is a c...

biorxiv.org

I suspect it's not widely known that (or how much) genetic variation that would otherwise be deleterious is "hidden" by buffering. Much of that is accomplished by a protein called Hsp90. I've written a feature for Nature about it. www.nature.com/articles/d41...

These ‘master’ proteins protect us from deadly mutations — and could inspire new drugs

Biology has clever ways to mask the effects of potentially harmful gene mutations. Scientists are investigating how this ‘buffering’ works — and how to exploit it.

nature.com

Join @davidbalchin.bsky.social, group leader here at the Crick, as he describes the fascinating ways our cells ensure that proteins fold correctly, and what happens when this goes awry in disease. youtu.be/gEgK1JDNlZ8

How Are We So Good at Folding Proteins? - With David Balchin

YouTube video by The Francis Crick Institute

youtu.be

"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...

Interview with Noboru Mizushima – President of the Japan Society for Cell Biology

Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...

journals.biologists.com

The twisted tale of cotranslational protein complex assembly My friend Saurav wrote this with Ayala Shiber and this is a great review. www.sciencedirect.com/science/arti...

The twisted tale of cotranslational protein complex assembly

Macromolecular complexes are cells’ functional units, and their correct and efficient assembly is critical to life’s processes. Complex assembly was c…

sciencedirect.com

Join scientists working on #ProteinHomeostasis in the EMBO Workshop "Proteostasis shaping health span: From protein folding to failure" in #Ericeira, #Portugal, 9–13 November 2026. Deadline: 1 September 2026 https://meetings.embo.org/event/26-proteostasis #EMBOproteostasis #EMBOevents 🧪

New from our lab @crick.ac.uk. Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones. Which chaperones recognise specific nascent chains, and what dictates their binding preferences? www.biorxiv.org/content/10.6...

UK Proteostasis Meeting 2026- Submit your abstract soon! Don’t miss the chance to present: most talks will be chosen from submitted abstracts, with poster presenters also invited to give a flash talk. ECRs are especially encouraged to apply. Deadline: 1 May 2026 Register: forms.gle/dWz2qztKgftB...

UK Proteostasis meeting 2026

IMPORTANT - ensure that in addition to completing this registration form, you complete payment on the conference Eventbrite page [add hyperlink] Registration for the conference is contingent on comple...

forms.gle

Proteostasis UK@proteostasisuk.bsky.social · 5mo ago

UK Proteostasis Meeting 2026 – Reminder: Register Today
 📅 20–21 July 2026 at The Francis Crick Institute, London 🗓 Abstract deadline: 1 May 2026
 💷 Fees: £45 (Student/Postdoc) | £75 (Group Leader) 🔗 Register: forms.gle/dWz2qztKgftB...
 🔗 Payment: www.eventbrite.co.uk/e/uk-proteos...

Postdoc opening with us at EPFL! Experimental project on how ATP driven chaperone cycles keep proteins out of equilibrium. We will quantify energy use, kinetics, and functional outcomes, including clients whose native-like functional state is stable only by sustained chaperone action.

UK Proteostasis Meeting 2026 – Reminder: Register Today
 📅 20–21 July 2026 at The Francis Crick Institute, London 🗓 Abstract deadline: 1 May 2026
 💷 Fees: £45 (Student/Postdoc) | £75 (Group Leader) 🔗 Register: forms.gle/dWz2qztKgftB...
 🔗 Payment: www.eventbrite.co.uk/e/uk-proteos...

Proteostasis UK Logo Competition Design our new logo and win registration, UK‑based travel, and accommodation to attend the UK Proteostasis Meeting 2026, 20–21 July at The Francis Crick Institute, London. See here for more information: proteostasisuk.co.uk/calls/proteo... Deadline: 1st May 2026

Our recent investigation of the constriction in the bacterial ribosomal tunnel is online. Unbiased all-atom MD simulations of the entire ribosome and PDB analysis show, how flexible the constriction is. The flexibility is modulated by short nascent polypetides.

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 5mo ago

Early nascent polypeptide dynamics are coupled to the flexibility of the ribosomal tunnel constriction https://www.biorxiv.org/content/10.64898/2026.03.10.710814v1

Ubiquitin & Friends Fiesta in Vienna, 29-30 April 2026. Great speakers, small size, a friendly community, perfect for early-career researchers to connect with fellow ubiquitin enthusiasts. Sign up at www.protein-degradation.org/symposium/ and submit abstracts for talks and awards. #ubfriends26

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community! We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.

Proteostasis UK@proteostasisuk.bsky.social · 6mo ago

📣 UK Proteostasis Meeting 2026 – Registration Now Open! I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026
. Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)

I'm thrilled to share our new publication, with co-first author @ Niko Dalheimer, is now out on Nature. Check out how we use live cell single particle tracking to study real time dynamics between TRiC chaperonin system and it substrates in the crowded cellular environment.

Niko Dalheimer@niko-dalheimer.bsky.social · 6mo ago

I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...

I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...

Single-molecule dynamics of the TRiC chaperonin system in vivo - Nature

Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.

nature.com

New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement. www.biorxiv.org/content/10.6...

Our latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells. www.cell.com/molecular-ce...

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. Roeselová and Shivakumaraswamy et a...

cell.com

If anyone is interested in making bacterial ribosome-nascent chain complexes and studying them using HDX-MS, we have written up a detailed protocol. rdcu.be/eYFx4 Characterise the conformational dynamics of the ribosome, nascent polypeptide and bound chaperones, label-free and at peptide-level

Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026

Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️ 📄 Read the preprint: biorxiv.org/content/10.6... #StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain

The ribosomal exit tunnel is a universally conserved feature of the large subunit that directs the nascent polypeptide chain into the cellular environment and is involved in co-translational folding, ...

biorxiv.org

Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk. www.nature.com/articles/s41...

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome - Nature Communications

The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...

nature.com

Postdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.

Postdoc (m/f/x)

Our Research Group led by Janine Kirstein, Professorin at Friedrich-Schiller-University Jena, is looking for a highly motivated and talented Postdoctoral Researcher (m/f/x) to join a research project ...

jobs.leibniz-fli.de

Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud...

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.