🚨 New preprint alert! 🚨 Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6... A tread 🧵⬇️

Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

biorxiv.org

Excited to share that our **3D-4i multiplexed imaging method** is now out in @natcomms.nature.com 🎉 🔗 www.nature.com/articles/s41... Huge thanks to the reviewers and editor for their constructive feedback and smooth handling of the work!

Shayan Shamipour@shamipourshayan.bsky.social · 11mo ago

Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊 Huge kudos to Max Hess for this PhD milestone! 💪 @lucaspelkmans.bsky.social shorturl.at/cO0u7 Let's zoom in!

Pathway to Independence – an interview with Nikhil Mishra In this interview, @nikhil-mishra.bsky.social discusses the evolution of his research interests from subcellular beginnings to whole-organism questions, and the importance of scientific security. doi.org/10.1242/dev....

Join the Open Bioimaging Practices Meetup all about OME-Zarr viewers on Monday, August 24th, 4pm CEST. Learn about ViZarr, napari & VolE & hear user stories on how they handle OME-Zarrs. More info here: www.biovisioncenter.uzh.ch/en/events/Up...

Wu, P. H., Phillip, J. M., Du, W., Forjaz, A., Nair, P. R., & Wirtz, D. (2026). Methods to analyze cell migration data: fundamentals and practical guidelines. Nature methods, 23(1), 43–55. #EpithelialMechanicsReview buff.ly/WtqtEf4

I will be opening my research group at the Max Delbrück Center later this year to unravel the principles governing the unique context sensing capacity of the liver www.mdc-berlin.de/schwayer and am looking for enthusiastic PhD applicants.

Schwayer Lab

The mammalian liver possesses a regenerative capacity that is unmatched by any other organ. Following injury, liver epithelial cells can proliferate or even change their identity, enabling the organ t...

mdc-berlin.de

This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...

Basement membrane turnover controls cell shape

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...

cell.com

#Twisting embryos and multiple #attachment sites in #Drosophila - now both available as #preprints. Proud of @giuliaserafini.bsky.social & @cuencam15.bsky.social, who worked together & established theory collaborations with @lepuslapis.bsky.social & @carldmodes.bsky.social @mpi-cbg.de at its best

How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

Analysis and video: thedailybritain.co.uk/polanski-dal...

Why aren't Britain's colonial history and the Balfour Declaration taught in schools? William Dalrymple joins Zack Polanski to explain

Historian William Dalrymple joins Zack Polanski on Bold Politics to explain how one corporation conquered India, how Britain created the conditions for the Nakba - and why none of it is on the school ...

thedailybritain.co.uk

Fantastically interesting podcast - wide-ranging, nuanced, stuffed full of information that I no idea about (and I thought I was reasonably well read in this area). @willdalrymple.bsky.social talks to @zackpolanski.bsky.social #Palestine #India #Lebanon www.youtube.com/watch?v=13zQ...

The British Empire’s Downfall: From India to Palestine | William Dalrymple

YouTube video by Bold Politics with Zack Polanski

youtube.com

Already out for a while as the final version: Our @elife.bsky.social paper presenting an experimental and computational pipeline for whole mount deep imaging and multi-scale analysis of organoid systems: elifesciences.org/articles/107... A great collaboration during my postdoc in Marseille.

A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization...

elifesciences.org

Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 4mo ago

User-friendly pipeline Tapenade quantifies spatial patterns of gene expression & nuclear morphology in 3D cell assembly '...oids' 📹 @alicegros.bsky.social, @jules-vanaret.bsky.social, @dunsingvalentin.bsky.social et al @centuri-ls.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2026...

The @ibroorg.bsky.social World Congress program committee has finalized a 🔥 keynote and special lecture line up. Stay tuned! In the meantime, symposia submissions are still open. Join us in Cape Town next year for this unique global neuroscience meeting! ibroworldcongress.org/open-calls/c...

🚀Excited to share our latest efforts in bringing highly multiplexed whole-mount imaging to intact multicellular systems! Shield-4i: an integrated platform to study multi-scale information flow in 3D embryos and embryo-like systems. Kudos to @rhornb.bsky.social for this major milestone in the lab!🚀

Super excited that the first preprint from the lab is out! Led by an amazing student, Gaurav @gvaidya.bsky.social, jointly supervised with @mwdorr.bsky.social.

Gaurav Vaidya@gvaidya.bsky.social · 3mo ago

The first preprint from my PhD is out! :thread: How does an animal choose between two completely different reproductive fates? Here’s how one planarian does it :point_down: www.biorxiv.org/content/10.6...

Happy to share our perspective on Mechanobiology across scales! This started as a stimulating discussions at the N4M conference, Camogli 2 years ago and culminated through lots of discussions, edits and co-working!Special thanks to Daniel Müller and his lab for coordinating and driving this work 🍾📣

Nature Nanotechnology@natnano.nature.com · 3mo ago

How does an ovarian follicle remodel in space and time to release an egg? 💥🥚 We have an exciting PhD project combining follicle culture, advanced imaging and quantitative analysis to understand the cellular dynamics of ovulation. 🔬 Co-supervised by me and @guignardlab.bsky.social. Please share! 🌱

These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

If you've been wondering what our current obsession with OME-Zarr and lego blocks is about, I have good news for you: the Fractal preprint is out! Thanks to @joelluethi.bsky.social , all co-authors, and the Fractal developers and users community for making this beautiful project a reality ❤️

Joel Lüthi@joelluethi.bsky.social · 7mo ago

We’re excited to share our latest preprint on Fractal: our approach towards FAIR bioimage analysis at scale with OME-Zarr-native workflows. Fractal defines interoperable tasks on OME-Zarr and provides a platform for TB-scale image analysis. (1 / 10🧵) www.biorxiv.org/content/10.6...

And here is the link to access the whole pdf. Enjoy! I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic. PDF: tinyurl.com/4hn34t8w

1/ 🚀🧪🤖 Big update for #Omega — the LLM-powered autonomous agent for bioimage analysis in @napari.org ! Custom LLM endpoints, layer actions, plugin extensibility, agentic widget maker, modernized UI, & 30+ fixes. Here's what's new in version *2026.2.8.2*:

In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...

A high-resolution, easy-to-build light-sheet microscope for subcellular imaging

An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.

doi.org

Checkout this updated preprint-a tour de force and truly globe-spanning collaboration with an exceptional group of scientists.

NEXT TUE: DDD seminar, Jan. 27, 2025 @ 1PM Eastern US: Nadezhda Azbukina @nazbukina.bsky.social (from Dr. Barbara Treutlein's group) will speak on "A systematic study of morphogen patterning and its reproducibility in human neural organoids". carlocolantuoni.org/seminar

Open-source atlas of fruit fly development DynamicAtlas is a high-res framework for morphological studies 📹 M. F. Lefebvre, V. Jain-Sharma, N. Claussen & N. P. Mitchell et al @streichan.bsky.social lab University of California Santa Barbara in @natmethods.nature.com ➡️ bpod.org.uk/archive/2026...

📣Registration deadline approaching !📣 Check out @embo.org @biologists.bsky.social workshop "biophysical & molecular mechanisms of animal homeostasis & repair" 6-10th April, with a fantastic lineup of speakers! meetings.embo.org/event/26-hom.... Register/Abstract submission by 10th January.

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

In @natphys.nature.com, they demonstrated that the zebrafish embryo “reads” and correctly interprets the zygote’s geometry during the initial few minutes of its existence. They discovered ... 📷 C.-P.Heisenberg, N. Mishra, Y. I. Li (from left to right).

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

I am extremely happy to see this work online! Long discussions about which, when and how much of morphogens or combinations result in what neural cell type/brain patterning culminated in this wonderful story, powered by multiplexed single-cell RNAseq. Follow the thread for a concise intro 🎊📣

@fatimasnc.bsky.social · 9mo ago

Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩 ✨Our latest paper might help you✨ tinyurl.com/neorgpat #morphogen #neuralorganoids #patterning #scRNAseq @graycamplab.bsky.social @ethz.ch @nazbukina.bsky.social