Explore questions and ideas in #CellPolarity across scales. Janelia, May 2-5, 2027 Lodging & meals covered. Apply by Jan 21 @ janelia.news/POL27
Sebastian Streichan
@streichan.bsky.social
Excited about animal and synthetic morphogenesis, light-sheet microscopy, and quantitative biology
Excited to share my second first-authored paper with zernickagoetz.bsky.social! Using live imaging, lineage tracing & scRNA-seq, we revise a long-held model of placental origins, showing "border" mural trophectoderm cells migrate to build the placenta at implantation. www.nature.com/articles/s41...
#Mastodon: the command center for large-scale lineage-tracing microscopy datasets has been published in @dev-journal.bsky.social. Allow me to say a few words about the genesis of this advanced #Fiji plugin (1/16)
Happy to share our newest preprint from @rdiegmiller.bsky.social . Rocky came up with important innovations that allow for the first time to image regeneration dynamics in pectoral fins quantitatively. www.biorxiv.org/content/10.6...
Asymmetric regeneration dynamics in zebrafish pectoral fins
Appendage amputation in regeneration-capable systems results in the full re-formation of lost tissue and cell populations. Despite an appreciation of this phenomenon in a select number of organisms, t...
biorxiv.org
Join @washugenetics.bsky.social next Thursday Nov. 12 at Noon in Connor Auditorium when Moritz Mall, PhD @moritzmall.bsky.social presents, “Regulation of cellular plasticity in development and disease”, hosted by Dr. Joe Dougherty!
Can we keep a cancer cell from changing its fate? Our @nature.com studies show that glioblastoma cells switch along predictable paths, and that the least plastic state is actively maintained by safeguard repressors led by MYT1L. doi.org/10.1038/s41586-026-11177-0 doi.org/10.1038/s41586-026-11234-8
🚨 FULLY FUNDED #DevBio PHD PROJECT 🚨 The Cardiac Positioning System – how do heart progenitors find their way? Discover how migrating cardiac progenitors navigate from primitive streak to heart field. 🧪🔬🐣❤️ With Prof Andrea Münsterberg and myself in Norwich UK. tinyurl.com/2np3k9x7 Please RP 🙏
What if the segmentation clock does more than tell an embryo when to make a segment? In our new paper in @cp-devcell.bsky.social, we show that it also helps coordinate tissue growth with segmentation, promoting robust somite formation! 🧵👇 www.cell.com/developmenta...
Metabolism is traditionally studied at the individual cell level, yet its role during development is very much under-appreciated. @mongeralab.bsky.social, @matyasbl.bsky.social and Olivier Pourquié lab discuss this interesting interplay between metabolism and morphogenesis: doi.org/10.1242/dev....
Recruiting! Joint PhD studentship with the laboratory of Silvia Santos @santoslab.bsky.social at the Francis Crick institute to examine the mechanics and growth control of human post-gastrulation amnioids. Deadline: 03/11/2026. Details on the project: www.crick.ac.uk/careers-stud...
In preprints – pushing the limits of morphogen scaling in #limbregeneration @jcornwallscoones.bsky.social discusses a recent preprint by Tardivo, Tanaka & co that shows how #morphogenscaling coordinates growth & patterning to determine the form of a regenerated limb. doi.org/10.1242/dev....
In preprints – pushing the limits of morphogen scaling in limb regeneration
This article discusses the preprinted work of Tardivo et al. (2026, preprint). As a preprint, this work has not yet undergone peer review.
doi.org
Registration is open for the 2027 @embo.org Workshop on Cell Polarity and Membrane Dynamics, co-organized with @alexludwig.bsky.social and @dianapinheiro.bsky.social. Join us in May 2027 in Sant Feliu de Guíxols, near Barcelona! meetings.embo.org/event/27-cel... #EMBOCellPolarity
Cell polarity and membrane dynamics
Cell polarity and membrane dynamics are fundamental principles underlying cell behavior, tissue organization, and organismal development. Recent years have brought about considerable conceptual and t…
meetings.embo.org
New paper by Harshath Amal @harshath.bsky.social shows how TGF-β signaling controls epithelial permeability by regulating actomyosin contractility and adhesion. Surprisingly, elevated adhesion can maintain barrier integrity independently of contractility tinyurl.com/ywenrexy @jcellsci.bsky.social
🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...
So proud of @yusuke-mori.bsky.social and happy to see this out. Big shout out to our collaborators @ehannezo.bsky.social and Paul Robin. Take a read if you are curious about Yap, feedbacks, the ECM, adhesion GPCRs and #morphogenesis www.nature.com/articles/s41...
A self-limiting mechanotransduction feedback loop ensures robust organ formation - Nature Communications
Developing tissues must acquire the correct shape. This study shows that mechanical feedback between the extracellular matrix and Yap sustains timely tissue growth, while Adgrg6 terminates the feedbac...
nature.com
Our work is finally out! How do organs get the right shape and size on time? Using the zebrafish inner ear canal, we show that a mechanical feedback loop between the ECM and Yap1 drives timely tissue growth, and a built-in termination system shuts it down once morphogenesis is done.
Our work is finally out! How do organs get the right shape and size on time? Using the zebrafish inner ear canal, we show that a mechanical feedback loop between the ECM and Yap1 drives timely tissue growth, and a built-in termination system shuts it down once morphogenesis is done.
A self-limiting mechanotransduction feedback loop ensures robust organ formation - Nature Communications
Developing tissues must acquire the correct shape. This study shows that mechanical feedback between the extracellular matrix and Yap sustains timely tissue growth, while Adgrg6 terminates the feedbac...
nature.com
New preprint! Antibodies activate an immune response… so why do immune cells have an inhibitory receptor FcγRIIB that binds antibodies? We found that FcγRIIB sets a time-limit for signaling. This makes macrophages eventually quit phagocytosis and prevents inflammation. doi.org/10.64898/202...
Happy to share our latest preprint in collaboration with @bashorlab.bsky.social. Great work by first author Alena Streletskaia. biorxiv.org/content/10.6...
We built a fully functional LegoAFM for imaging! 🤩... Today presented at #TürenAuf Tag der #SendungMitDerMaus! ... Remember: Always be curious! ⁉️
My work on the turquoise killifish photoreceptor mosaic was published last week - check it out if you’re interested in photoreceptors, cell organization, and pretty pictures! onlinelibrary.wiley.com/doi/10.1002/...
Ordered Chaos: Photoreceptor Mosaics in the Larval and Adult Turquoise Killifish (<i>Nothobranchius furzeri</i>)
The annual turquoise killifish (Nothobranchius furzeri) cone photoreceptor mosaic is an ordered lattice but lacks regularity of cone subtypes in adulthood. The cone mosaic differs between life stages...
onlinelibrary.wiley.com
How do plant organs stay smooth—or become wrinkled? 🌱 Our paper in @currentbiology.bsky.social shows how coordinated growth direction and mechanical properties across cell layers determine whether Arabidopsis sepals remain smooth or buckle. cell.com/current-biol...
Don´t know yet what you´ll be doing next April? Why not join us for a great meeting in Porto? Registration for Forces across scales is now open! meetings.embo.org/event/27-for...
Forces across scales
This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…
meetings.embo.org
Join us in Sheffield! The DRN Research Cluster is looking to recruit new Independent Research Fellows. Contact the cluster lead, Dr Matt Towers, if you are interested!
Our summer academy on "Science and Histories of Fever" is in full swing at the Marsilius Kolleg, with great talks from e.g. @kakape.bsky.social, @feverprojecthd.bsky.social and @lendertgelens.bsky.social. If you are around, join us for "Marsilius Kontrovers" tonight at 7 pm: tinyurl.com/y8dkkxw4
Very excited to finally share NeMo! 🌀🐟 Such a cool tool for anyone working with curved surfaces, and especially curved nematics. Really happy to have been part of this project and great team! arxiv.org/abs/2609.12906
NeMo is finally out! 🐟 We present our new method to peel cellular layers and extract their nematics. If you're wondering what a fish has to do with curved nematics, check out the thread and the publication 👀👇🏼 arxiv.org/html/2609.12...
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
Last day to register for AQMHD is this Friday, Sept. 25! They’re also still accepting poster abstracts!
🗓️ AQMHD 2026 reminder: Registration closes THIS FRIDAY, Sept. 25 at 6:00 PM! Planning to join us Oct. 17–21 at the Marine Biological Laboratory in Woods Hole? Now is the time to register! aqmhd.org 🧵 1/3
In @pcusachs.bsky.social’s lab at @ibecbarcelona.eu we have a fully founded open PhD position! It’s a very nice working environment & can promise cool mechanobiology🔬🧫 Here all the info ibecbarcelona.eu/predoctoral-...
ibecbarcelona.eu
Our latest paper on building models of cell fate decisions -with David Rand, Marine Fontaine & @joadelas.bsky.social- combines developmental biology, dynamical systems theory and bioinformatics. I wrote a short piece to summarise it & explain ideas behind the approach briscoelab.org/blog-quantif...
Quantifying Waddington's Landscape | Briscoe Lab
I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...
briscoelab.org
The Brantley Lab is hiring a Research Technician/Lab Manager! Looking for someone with a strong foundation in molecular biology, a team player, and excited about basic science. If you know someone who would be a great fit, please share! spartantalent.uncg.edu/postings/35995
Research Lab Technician
The Brantley Lab is seeking a Research Technician who is passionate about basic science and being a reliable, collaborative member of an academic research team. Research in the Brantley Lab uses quant...
spartantalent.uncg.edu