How do epithelial cells integrate mechanical and biochemical signals to control their behavior? I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.

Another brilliant Sheffield Pancreatic Cancer Research Network meeting. We heard two fantastic researchers working at the cutting edge of PC. Samrein Ahmed (SHU) shared mechanistic insights into RLIP76, and Helen Matthews (UoS) explored adhesion-dependent resistance to KRAS inhibition.

It was a huge honour to be able to present my PhD work recently at #DynamicCellVI ☺️ @bscb-official.bsky.social @biochemsoc.bsky.social thank you for having me and thank you for an incredible conference!

Helen Matthews@helenkmatthews.bsky.social · 4mo ago

Fantastic talk by Rachel @rlawson954.bsky.social presenting her PhD work on keratins in mitosis at @bscb-official.bsky.social @biochemsoc.bsky.social #DynamicCellVI 👏👏👏 @mcb-sheffield.bsky.social

Fantastic talk by Rachel @rlawson954.bsky.social presenting her PhD work on keratins in mitosis at @bscb-official.bsky.social @biochemsoc.bsky.social #DynamicCellVI 👏👏👏 @mcb-sheffield.bsky.social

Wishing everyone a bright and happy Deepavali!

New release of #BigTrace plugin is out. Together with @aafkegros.bsky.social from Simone Köhler group we added a fully automatic tracing mode. + more macro functions and bug fixes github.com/ekatrukha/Bi...

🔔🧪 Call for Papers – #Mechanobiology of the #ExtracellularMatrix 🧬🛠️ Excited to serve as Guest Editor — together with Jacopo di Russo and Jennifer Young — of a new 𝐧𝐩𝐣 𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐏𝐡𝐲𝐬𝐢𝐜𝐬 𝐚𝐧𝐝 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐜𝐬 Collection on “Mechanobiology of the ECM”. Deadline: 14 May 2026! www.nature.com/collections/...

Mechanobiology of the Extracellular Matrix

This Collection aims to highlight fundamental and translational advances in ECM mechanobiology.

nature.com

Now in @natnano.nature.com: We need to acknowledge that - as with all new tech - AI also poses hazards we need to be aware of. Thanks @besfordgroup.bsky.social (Quinn A. Besford 🇦🇺🇩🇪🇺🇦) for leading this effort. www.nature.com/articles/s41...

The rising danger of AI-generated images in nanomaterials science and what we can do about it - Nature Nanotechnology

Generative AI has made it trivial to generate fake microscopy images that are indistinguishable from real images, even for experts. As researchers in nanoscience, it is time for us to face this realit...

nature.com

Is your red the same as my red?

Thank you so much for this incredible opportunity at an incredible institution!!

Mechanobiology Institute@mbisg.bsky.social · 11mo ago

What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social

Still blown away that I’m getting the chance to be here in Singapore for the MBI Mechanobiology conference, and not only that but also having the chance to present my #PhD work as a talk. Incredible opportunity and getting also to hear about amazing research from around the world 🌍 #mechanobiology

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling

Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏

A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social

Had a great time at Physics Within The Cell hosted by the IOP today, and it was such an honour to share my work on epithelial division mechanics there ☺️ Thank you! @instituteofphysics.bsky.social #biomechanics #mitosis #phdlife #conferences

Must say I’m very proud of the start I’ve made to thesis writing #phdthesis #thesiswriting #phdlife

Happy to publish this News & Views article highlighting exciting new work from Rod Bremner's lab that shows that cell populations with a short cell cycle are intrinsically more susceptible to forming tumours

Barbara Marte@barbmarte.bsky.social · last yr.

and the News & Views www.nature.com/articles/d41...

Neuroscientists have identified a brain signal in mice that kick-starts the process of overwriting fearful memories once danger is passed — a process known as fear extinction. https://go.nature.com/3REKSZb

‘Fear extinction’ signal in mouse brain offers clues about how to treat PTSD

Mechanism involving neurons that stimulate fear, and ones that suppress it, could help to explain conditions such as post-traumatic stress disorder.

go.nature.com

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. https://go.nature.com/437FWT6

The do’s and don’ts of scientific image editing

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

go.nature.com

Less than two weeks to go! Thanks for all the donations! www.justgiving.com/team/thalia

Thalia’s Team fundraising for OSCAR's Paediatric Brain Tumour Charity

Help Chris Toseland raise money to support OSCAR's Paediatric Brain Tumour Charity

justgiving.com

Chris Toseland@christoseland.bsky.social · last yr.

We are walking the Ullswater Way with OSCAR's Paediatric Brain Tumour Charity in May. Learn more and donate here: www.justgiving.com/team/thalia #braintumours #childhoodcancer #cancer

It took an extension to the extension of the extension, but after more than 3 years of negotiations, governments around the globe—but notably, not the United States—have finally agreed on a treaty to improve how the world prevents, prepares for, and responds to future pandemics. scim.ag/4lDYcLe

Global pandemic treaty finalized, without U.S., in ‘a victory for multilateralism’

Three years in the making, the accord aims to increase equity and avoid errors of the COVID-19 pandemic

scim.ag

Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊

www.nature.com/articles/s42...

Scientists identify key protein driving ovarian cancer spread @mcb-sheffield.bsky.social www.sheffield.ac.uk/biosciences/...

Scientists identify key protein driving ovarian cancer spread

A new study has identified the protein ADAMTS5 as playing a crucial role in the spread of ovarian cancer cells, offering a potential new target for future treatments.

sheffield.ac.uk

Excited to share that our latest paper is out today!!! 'The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25' - great effort by Sherry and Rachele (1/6) @febsj.bsky.social @mcb-sheffield.bsky.social febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found t....

febs.onlinelibrary.wiley.com

Happy Caturday to all those science cats helping their owners with their research 😂☺️ #caturday #sciencecats #phdlife #biology

Meanwhile in Harrogate... Rachel & Bella from the lab are presenting at @physicsoflifeuk.bsky.social #physicsoflife2025

Congratulations to Bella for winning a poster prize at @physicsoflifeuk.bsky.social 2025 👏👏👏🎉🎉 #proudPI @mcb-sheffield.bsky.social