Rainero lab
@erainerolab.bsky.social
We are in @mcb-sheffield.bsky.social, School of Biosciences at the University of Sheffield. We are interested in understanding how the extracellular matrix controls cancer cell migration, growth and metabolism. @plosbiology.org Editorial Board Member
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology. For more info 👇 sheffield.ac.uk/biosciences/...
Proud to have been awarded LEAF Silver (again) - with @helenkmatthews.bsky.social lab!! @mcb-sheffield.bsky.social
📣 Fully funded PhD position available in collaboration with @jasonkinglab.bsky.social in @mcb-sheffield.bsky.social BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? 📅 Deadline: 7th January 2026 More info 👇 www.findaphd.com/phds/project...
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield on FindAPhD.com
PhD Project - BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield, listed on FindAPhD.com
findaphd.com
Fantastic presentation by Ife at the Sheffield Pancreatic Cancer Network!! @mcb-sheffield.bsky.social
We are delighted to host Harsha Kantamneni today from the University of Bradford. "Endosomal Sorting Complex Required for Transport (ESCRT): Roles in receptor trafficking, signalling pathways, drug resistance and disease" 📍 Alfred Denny Conference Room 📅 18th October - 1pm
Congratulations to Shahd on passing her PhD viva!!!! Thanks to Christoph and Jason @jasonkinglab.bsky.social for examining
The integrin odyssey - a journey full of fundamental discoveries. pubmed.ncbi.nlm.nih.gov/40988584/
The integrin odyssey - a journey full of fundamental discoveries - PubMed
Integrins are widely expressed cell adhesion receptors that link extracellular matrix proteins to the cytoskeleton. Most integrins connect to the actin cytoskeleton through different types of adhesion...
pubmed.ncbi.nlm.nih.gov
#NPAW2025 #PostdocAppreciationWeek Rachele is a @yorkshirecancer.bsky.social funded postdoc, investigating the role of the Rab25/ADAMTS5 axis in ovarian and pancreatic cancer peritoneal metastasis. You can read more about this here: sheffield.ac.uk/biosciences/... @mcb-sheffield.bsky.social
Sheffield scientists to be a key part of a groundbreaking Yorkshire Cancer Research hub
Scientists from the School of Biosciences have received over £580,000 in funding from Yorkshire Cancer Research.
sheffield.ac.uk
Great talk by our own Zhe Bao at the School of Biosciences 3rd year PGR symposium!! @mcb-sheffield.bsky.social
#NPAW2025 #PostdocAppreciationWeek Eric is a @breastcancernow.bsky.social funded postdoc, investigating the mechanisms of breast cancer cell growth and spread. You can read more about this here 👇: breastcancernow.org/our-research... @mcb-sheffield.bsky.social
Investigating mechanisms of breast cancer cell growth and spread
Dr Elena Rainero is investigating how breast cancer cells use alternative energy sources to grow and spread, and the role of protein called a2b1 integrin in this.
breastcancernow.org
#NPAW2025 #PostdocAppreciationWeek Mona is a @cancerresearchuk.org funded postdoc in our lab. She demonstrated that the #ECMatrix supports breast cancer cell growth under starvation by promoting tyrosine catabolism. You can read more about this here: 👇 pubmed.ncbi.nlm.nih.gov/38227562/
Here are our fantastic postdocs: Mona, Rachele & Eric @mcb-sheffield.bsky.social #NPAW2025 #PostdocAppreciationWeek
Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer click.notification.elsevier.com/CL0/https:%2...
Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
Zhang et al. demonstrate that macropinocytosis inhibition induces myCAF-to-iCAF conversion through a metabolically stressed, MEK-ERK-dependent intermediate state. This CAF plasticity remodels the panc...
click.notification.elsevier.com
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics
Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by low sensitivity for small molecules, limited scalability, and the lack of standardized frameworks for data analysis....
cell.com
Our own Ife will present her PhD work!!
Victoria Hart@vichart33.bsky.social · 12mo agoInterested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting! Check out the details at: sites.google.com/sheffield.ac... @mcb-sheffield.bsky.social @fohsheffield.bsky.social
SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.27.672673v1
We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction 🔗 www.biorxiv.org/content/10.1... 📦 saezlab.github.io/MetaProViz/ 🧵 Thread ⬇️
The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge. pubmed.ncbi.nlm.nih.gov/40705420/
The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge - PubMed
The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occu...
pubmed.ncbi.nlm.nih.gov
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration. pubmed.ncbi.nlm.nih.gov/40669465/
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration - PubMed
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain l...
pubmed.ncbi.nlm.nih.gov
A unified pan-cancer proteome atlas www.cell.com/cancer-cell/...
A unified pan-cancer proteome atlas
In this issue of Cancer Cell, Knol et al. present the Pan-Cancer Proteome Atlas (TPCPA), a proteomic resource developed using single-shot data-independent acquisition mass spectrometry (DIA-MS). TPCPA...
cell.com
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration. pubmed.ncbi.nlm.nih.gov/40614209/
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration - PubMed
Endocytic recycling pathways play key roles in a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (R...
pubmed.ncbi.nlm.nih.gov
Outside influences: The impact of extracellular matrix mechanics on cell migration. pubmed.ncbi.nlm.nih.gov/40571339/
Outside influences: The impact of extracellular matrix mechanics on cell migration - PubMed
"No cell is an island" - highlights the interconnectedness of cellular behavior and the extracellular matrix (ECM). Cell migration is inherently contextual, as cells navigate and adapt to their enviro...
pubmed.ncbi.nlm.nih.gov
Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios. thenode.biologists.com/event-carbon...
Event carbon calculator - the Node
I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your
thenode.biologists.com
Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start! @mcb-sheffield.bsky.social
Fantastic lab walk with @helenkmatthews.bsky.social ! Thanks to Bian, Rachele and @vichart33.bsky.social for organising
Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages www.cell.com/developmenta...
Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages
Huang et al. demonstrate that the intermediate filaments protein vimentin orchestrates actin stress fibers and podosomes, thereby facilitating efficient extracellular matrix (ECM) degradation via inte...
cell.com
🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs
