Congratulations @tomgolde.bsky.social 🎉🎉🎉 Super amazing work.

Tom Golde@tomgolde.bsky.social · last wk.

New paper in @natphys.nature.com! We uncovered a stress adapation mechanism where keratin intermediate filaments in stretched epithelia undergo a supracellular bundling transition that uncages the nucleus. www.nature.com/articles/s41... @ibecbarcelona.eu, @upc.edu @qmul.bsky.social

New paper in @natphys.nature.com! We uncovered a stress adapation mechanism where keratin intermediate filaments in stretched epithelia undergo a supracellular bundling transition that uncages the nucleus. www.nature.com/articles/s41... @ibecbarcelona.eu, @upc.edu @qmul.bsky.social

Matejčić, M., Wang, M., López Serrano, E., Pérez-González, C., Houtekamer, R., Ceada, G., ... & Trepat, X. (2025). Mechanical Coordination of Intestinal Cell Extrusion by Supracellular 3D Force Patterns. bioRxiv, 2025-07. #EpithelialMechanics www.biorxiv.org/content/10.1...

How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

I wish you all a happy #EpithelialMechanics Day! May your cells cooperate with you to discover the most amazing physical phenomena.

epithelial mechanics fan club@epimechfc.bsky.social · 2w ago

🎉 Happy International #EpithelialMechanics Day! 🎉

🎉 Happy International #EpithelialMechanics Day! 🎉

From single-celled organisms to ciliated epithelia in metazoans, precise positioning of basal bodies (BBs), which anchor motile cilia, is essential for generating fluid flows. Here, I, @raghavan-thiaga.bsky.social, will take you on a brief tour of how cells build this spatial organization.

I am thrilled to share my PhD work with @nicolettapetridou.bsky.social @embl.org: www.biorxiv.org/cgi/content/... A fun collaboration with Bernat Corominas-Murtra, Adrián Aguirre-Tamaral, @bart-smeets.bsky.social , Jef Vanghel and Tom Belpaire! Read the story in the comments below ⤵️

With a motivating push from @christlet.bsky.social I made a new Fiji plugin, CurveMorph. The idea was to create a tool for kymograph generation along the dynamic (bending/shaking) filament shapes (microtubules, cilia, neurites, etc). The logo was made using the plugin. github.com/UU-cellbiolo...

What signals organise the global layout of the neocortex? Come to poster #2558 #OHBM2026 on Wednesday 13h45 or Thursday 14h45 to chat about folding, geometry, mechanics and genes! @k4tj4.bsky.social @julien-lefevre.bsky.social

Every 3D tissue is a map waiting to be drawn. Flatten a curved tissue, follow how it deforms, find its hidden axis, or measure its shape to explain how it moves: it's all cartography!

How are two embryos alike? As we collect spatio-temporal microscopy data, we want to quantify variability in the timing of key developmental events. Alignment of multiple recordings is a core engineering challenge here and we suggest a solution; read about it: www.biorxiv.org/content/10.6...

A quantitative coordinate system for developmental dynamics

Quantitative comparison of morphogenesis across individuals remains a fundamental challenge, as developing embryos vary in shape, orientation and developmental tempo. Moreover, real-time three-dimensi...

biorxiv.org

A day in the life of a Transgenic Quail lab Samara Ranie @samarar.bsky.social, PhD student in Melanie White's @melaniedwhite.bsky.social lab, reveals a day in the life of a transgenic quail lab. 🥚🔬 thenode.biologists.com/a-day-in-the...

A day in the life of a Transgenic Quail lab - the Node

Samara Ranie, PhD student in Melanie White's lab, takes us through a day in the life of a transgenic quail lab.

thenode.biologists.com

New paper in Advanced Materials! We present DNA hydrogel microparticles for 3D tissue engineering, showing programmable material properties and cell-material interactions! Special thanks to Eleni Dalaka @gflaesch.bsky.social @kgoepfrich.bsky.social @xaviertrepat.bsky.social doi.org/10.1002/adma...

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

We are excited to announce another new webinar series, this time on cell migration, hosted by @pjsaez.bsky.social & @valeriaventurini.bsky.social. In our 1st webinar, we’ll hear talks from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social. 🗓️11 June, 15:00 BST

New webinar series on cell migration - FocalPlane

New webinar series on cell migration - News

focalplane.biologists.com

How does a relatively simple tube become a complex brain? 🧠 One of the most dramatic transformations in development! We built a framework to map exactly what changes. 🧵 New preprint from my postdoc at @nerurkar.bsky.social lab: doi.org/10.64898/202...

Wound repair is more than simply closing a gap in the tissue. Mechanical injury rapidly reshapes signaling, nuclear organization, and cellular identity across the epithelium. I'm @johanajnabi.com, and here are studies that changed how I think about epithelial wound healing. bsky.app/profile/epim...

Hundreds of organelles. Disorder → order. No blueprint. The switch? Actin crosslinking. The moment the meshwork forms, Basal Body dynamics shift from diffusive to subdiffusive. Same transition. Same developmental window - Every time. New preprint from my postdoc. Full thread👇

kuba sędziński@kuba-sedzinski.bsky.social · 3mo ago

💥 🚀 New preprint! 🎉🥳 How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order 🍪 🧵👇 (1/17)

How does a relatively simple tube become a complex brain? 🧠 One of the most dramatic transformations in development! We built a framework to map exactly what changes. 🧵 New preprint from my postdoc at @nerurkar.bsky.social lab: doi.org/10.64898/202...

Researchers across Columbia brought the heat to campus yesterday to demand Columbia work with us, not against us, in reaching a fair contract! So far, Columbia has resisted common-sense improvements such as living wages and job security. When we fight, we win!✊ #UnionStrong #NYResearchersStandUp

happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...

Localized actin cortex perturbation generates cell-scale membrane tension gradients www.biorxiv.org/content/10.6...

Our thread is now up at @epimechfc.bsky.social 💗 Take a look if you are interested in how a living tissue knows how to sculpt itself!

epithelial mechanics fan club@epimechfc.bsky.social · 4mo ago

How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.

#DBfeature Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors By Olivia Powell, Emily Garcia, Vanshika Sriram, Yi Qu, Nandan L. Nerurkar tinyurl.com/52pecyc5

How do epithelial cells integrate mechanical and biochemical signals to control their behavior? I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.

My postdoc work with @pcusachs.bsky.social is finally out! We find that fibrillar adhesions play an important role regulating the timescales of nuclear mechanotransduction. You can read all about it here : www.nature.com/articles/s41563-026-02590-x Huge thanks to everyone involved!!

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton - Nature Materials

Nuclear deformation and mechano-signalling are regulated by the coupling of vimentin cytoskeleton to the extracellular matrix through fibrillar adhesions, modulating the timescale of mechanotransducti...

nature.com

I’m thrilled that my PhD project has finally come together as a publication!

Melanie D. White@melaniedwhite.bsky.social · 3mo ago

I'm SO excited to see this new paper from our lab's first PhD graduate @wangjianxiong.bsky.social. An outstanding student with a promising career ahead! A PCP-independent role for Prickle1 in junctional neural tube formation. 🧪🐣 Check it out: www.nature.com/articles/s41...

🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...

Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis

Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.

science.org