Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming! 🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis). www.cell.com/cell-stem-ce...

Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling

Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...

cell.com

(1/3) A while back, my then-PhD student @htstuart.bsky.social stumbled on a finding that changed our lab’s direction 👀✨. Turns out, STAT3 mediated reprogramming generates intermediates (Gata6GFP+ cells) going through an earlier developmental stage with increased developmental potential 🚀

📢 Recruitment for the EMBL International PhD Programme is officially open! At EMBL, we train young scientists to become skilled and creative future leaders in academia and other sectors. Join us and get a head start on your career in life sciences! bit.ly/47mmiFF

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

biorxiv.org

🌛Western sessions: Our classic VGZT seminars will continue bi-weekly on Thursdays, featuring the same time and format as before. Check out the speaker lineup and in the future, look for the 🌙 symbol in the flyers for individual sessions. [2/4]

📢Vote for the 2024 Development cover image of the year @dev-journal.bsky.social featured 24 cover images in 2024. Now is the chance to pick your favourite! Browse through the images and vote by 13 Jan: https://thenode.biologists.com/vote-for-the-2024-development-cover-image-of-the-year/ #DevBio