A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2 url: journals.biologists.com/jcs/article/... BIG Congratulations to all authors and particularly to the first author Birendra Kumar Shrestha who did a fantastic job !

A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2

Highlighted Article: The transcriptional coactivator TP53INP2 is degraded by nuclear proteasomes under basal conditions. Upon starvation and exposure to various chemical stressors, a conserved cytopla...

journals.biologists.com

WSTF nuclear autophagy regulates chronic but not acute inflammation is published in Nature😀 nature.com/articles/s41... Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀

WSTF nuclear autophagy regulates chronic but not acute inflammation @nature.com @terjejohansen.bsky.social www.nature.com/articles/s41...

Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming. Liu, Yue et al. Cell Metabolism, Volume 37, Issue 4, 920 - 935.e6 doi.org/10.1016/j.cm...

I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!

🚨 Paper Alert! We’re starting off the year with our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This work was a close and exciting collaboration with @wilflinglab.bsky.social 🔗 nature.com/articles/s41... Here's a thread👇

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

nature.com

Congratulations with a great paper and a massive amount of important work from Serhiy Pankiv in Anne Simonsen´s group creating a gold chest of reagents for studies of BEACH domain proteins!😀👍 doi.org/10.1083/jcb....

Exciting study about Gliocidin, a nicotinamide-mimetic prodrug, that targets glioblastoma!!! Chen, YJ., Iyer, S.V., Hsieh, D.CC. et al. Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Nature (2024). doi.org/10.1038/s415...

To celebrate the move to Bluesky, here is our recent review on autophagy, ageing, and age-related neurodegeneration: www.cell.com/neuron/fullt...

Autophagy, aging, and age-related neurodegeneration

This review discusses the links between the autophagy pathway, aging, and age-associated neurodegeneration in Alzheimer’s, Parkinson’s, motor neuron, and Huntington’s diseases. The authors highlight t...

cell.com

Fantastic study! Highly worth checking this out www.nature.com/articles/s41... for those interested in #aging #drosophila #mitochondria #autophagy

Accumulation of F-actin drives brain aging and limits healthspan in Drosophila - Nature Communications

Changes to actin dynamics during brain aging are not well understood. Here, the authors report that there is an age-related increase in F-actin in Drosophila brain which disables autophagy within the ...

nature.com

Delthia Ricks@dricks.bsky.social · 2y ago

Brain aging has been reversed in fruit flies by suppressing F-actin, a protein that serves as a key component of cellular structure. Both humans & fruit flies become forgetful w/ age, scientists are using the flies as models to reverse forgetfulness www.genengnews.com/topics/trans...